• Gene id: 79596

Gene Summary

• Gene Symbol: OBI1   Gene   UCSC   Ensembl
• Aliases: C13orf7, RNF219
• Gene name: ORC ubiquitin ligase 1
• Alternate names: ORC ubiquitin ligase 1, ring finger protein 219,
• Gene location: 13q31.1 (78659164: 78614285)     Exons: 7     NC_000013.11
• OMIM: 615906

Protein Summary

• Protein general information: Q5W0B1  
  • Name: ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219)
  • Length: 726  
  • Mass: 81116
• Sequence:

  MAQTVQNVTLSLTLPITCHICLGKVRQPVICINNHVFCSICIDLWLKNNSQCPACRVPITPENPCKEIIGGTSES
  EPMLSHTVRKHLRKTRLELLHKEYEDEIDCLQKEVEELKSKNLSLESQIKTILDPLTLVQGNQNEDKHLVTDNPS
  KINPETVAEWKKKLRTANEIYEKVKDDVDKLKEANKKLKLENGGLVRENLRLKAEVDNRSPQKFGRFAVAALQSK
  VEQYERETNRLKKALERSDKYIEELESQVAQLKNSSEEKEAMNSICQTALSADGKGSKGSEEDVVSKNQGDSARK
  QPGSSTSSSSHLAKPSSSRLCDTSSARQESTSKADLNCSKNKDLYQEQVEVMLDVTDTSMDTYLEREWGNKPSDC
  VPYKDEELYDLPAPCTPLSLSCLQLSTPENRESSVVQAGGSKKHSNHLRKLVFDDFCDSSNVSNKDSSEDDISRS
  ENEKKSECFSSPKTGFWDCCSTSYAQNLDFESSEGNTIANSVGEISSKLSEKSGLCLSKRLNSIRSFEMNRTRTS
  SEASMDAAYLDKISELDSMMSESDNSKSPCNNGFKSLDLDGLSKSSQGSEFLEEPDKLEEKTELNLSKGSLTNDQ
  LENGSEWKPTSFFLLSPSDQEMNEDFSLHSSSCPVTNEIKPPSCLFQTEFSQGILLSSSHRLFEDQRFGSSLFKM
  SSEMHSLHNHLQSPWSTSFVPEKRNKNVNQSTKRKIQSSLSSASPSKATKS

• Structural information:
  • Interpro: IPR039209  IPR035691  IPR001841  IPR013083  
  • Prosite: PS50089
  • CDD: cd16562
  • STRING: ENSP00000282003
• Other Databases: GeneCards:  OBI1  Malacards:  OBI1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004842	ubiquitin-protein transferase activity	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0006275	regulation of DNA replication	IDA	biological process
GO:0000785	chromatin	IDA	cellular component
GO:0006513	protein monoubiquitination	IDA	biological process
GO:0051865	protein autoubiquitination	IDA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0004842	ubiquitin-protein transferase activity	IEA	molecular function
GO:0006275	regulation of DNA replication	IEA	biological process
GO:0006513	protein monoubiquitination	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005694	chromosome	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005694	chromosome	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)