• Gene id: 79154

Gene Summary

• Gene Symbol: DHRS11   Gene   UCSC   Ensembl
• Aliases: ARPG836, SDR24C1, spDHRS11
• Gene name: dehydrogenase/reductase 11
• Alternate names: dehydrogenase/reductase SDR family member 11, 17-beta-hydroxysteroid dehydrogenase, 3-beta-hydroxysteroid 3-dehydrogenase, dehydrogenase/reductase (SDR family) member 11, estradiol 17-beta-dehydrogenase, inactive dehydrogenase/reductase isoform, short-chain deh,
• Gene location: 17q12 (36591845: 36600803)     Exons: 7     NC_000017.11
• OMIM: 612546

Protein Summary

• Protein general information: Q6UWP2  
  • Name: Dehydrogenase/reductase SDR family member 11 (17 beta hydroxysteroid dehydrogenase) (3 beta hydroxysteroid 3 dehydrogenase) (EC 1.1.1.270) (Estradiol 17 beta dehydrogenase) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 24C member 1)
  • Length: 260  
  • Mass: 28308
  • Tissue specificity: Isoform 1
• Sequence:

  MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEE
  DILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININ
  SMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMK
  CLKPEDVAEAVIYVLSTPAHIQIGDIQMRPTEQVT

• Structural information:
  • Interpro: IPR036291  IPR020904  IPR002347  
  • Prosite: PS00061
  • PDB: 1XG5
  • PDBsum: 1XG5
  • STRING: ENSP00000482704
• Other Databases: GeneCards:  DHRS11  Malacards:  DHRS11

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0008202	steroid metabolic process	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0006629	lipid metabolic process	IEA	biological process
GO:0004303	estradiol 17-beta-dehydrogenase activity	IEA	molecular function
GO:0000253	3-keto sterol reductase activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0006703	estrogen biosynthetic process	IEA	biological process
GO:0006694	steroid biosynthetic process	IDA	biological process
GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	IDA	molecular function
GO:0004303	estradiol 17-beta-dehydrogenase activity	IDA	molecular function
GO:0072555	17-beta-ketosteroid reductase activity	IDA	molecular function
GO:0000253	3-keto sterol reductase activity	IDA	molecular function
GO:0005575	cellular_component	ND	cellular component

KEGG pathways

Pathway id	Pathway name
hsa00140	Steroid hormone biosynthesis

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881