• Gene id: 79137

Gene Summary

• Gene Symbol: RETREG2   Gene   UCSC   Ensembl
• Aliases: C2orf17, FAM134A, MAG-2
• Gene name: reticulophagy regulator family member 2
• Alternate names: reticulophagy regulator 2, family with sequence similarity 134 member A, metastasis associated gene-2, protein FAM134A,
• Gene location: 2q35 (219178226: 219185474)     Exons: 9     NC_000002.12
• OMIM: 0

Protein Summary

• Protein general information: Q8NC44  
  • Name: Reticulophagy regulator 2
  • Length: 543  
  • Mass: 57830
• Sequence:

  MASGGGGGNTGAGGGPGMGLSLGLGLGLSLGMSEATSEAEEEAATAEAVGRLATTLWLRLRGWEAVLAAAQRLLV
  WEKPLHSLVTAAALNGLFWLLSSSSLRPFFLLSVSLLAYFLLDLWQPRFLPDVSASSPEEPHSDSEGAGSGARPH
  LLSVPELCRYLAESWLTFQIHLQELLQYKRQNPAQFCVRVCSGCAVLAVLGHYVPGIMISYIVLLSILLWPLVVY
  HELIQRMYTRLEPLLMQLDYSMKAEANALHHKHDKRKRQGKNAPPGGDEPLAETESESEAELAGFSPVVDVKKTA
  LALAITDSELSDEEASILESGGFSVSRATTPQLTDVSEDLDQQSLPSEPEETLSRDLGEGEEGELAPPEDLLGRP
  QALSRQALDSEEEEEDVAAKETLLRLSSPLHFVNTHFNGAGSPPDGVKCSPGGPVETLSPETVSGGLTALPGTLS
  PPLCLVGSDPAPSPSILPPVPQDSPQPLPAPEEEEALTTEDFELLDQGELEQLNAELGLEPETPPKPPDAPPLGP
  DIHSLVQSDQEAQAVAEP

• Structural information:
  • PDB: 6EWC
  • PDBsum: 6EWC
  • DIP: 56781
  • STRING: ENSP00000395249
• Other Databases: GeneCards:  RETREG2  Malacards:  RETREG2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016021	integral component of membrane	IBA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray