• Gene id: 79002

Gene Summary

• Gene Symbol: TRIR   Gene   UCSC   Ensembl
• Aliases: C19orf43, TERCIR, fSAP18
• Gene name: telomerase RNA component interacting RNase
• Alternate names: telomerase RNA component interacting RNase, My029 protein, exoribonuclease TRIR, uncharacterized protein C19orf43,
• Gene location: 19p13.13 (12734683: 12730639)     Exons: 3     NC_000019.10
• OMIM: 0

Protein Summary

• Protein general information: Q9BQ61  
  • Name: Telomerase RNA component interacting RNase (EC 3.1.13. ) (Exoribonuclease TRIR)
  • Length: 176  
  • Mass: 18419
• Sequence:

  MAARGRRAEPQGREAPGPAGGGGGGSRWAESGSGTSPESGDEEVSGAGSSPVSGGVNLFANDGSFLELFKRKMEE
  EQRQRQEEPPPGPQRPDQSAAAAGPGDPKRKGGPGSTLSFVGKRRGGNKLALKTGIVAKKQKTEDEVLTSKGDAW
  AKYMAEVKKYKAHQCGDDDKTRPLVK

• Structural information:
  • Interpro: IPR038838  
  • STRING: ENSP00000242784
• Other Databases: GeneCards:  TRIR  Malacards:  TRIR

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	IBA	biological process
GO:0008408	3'-5' exonuclease activity	IBA	molecular function
GO:0008409	5'-3' exonuclease activity	IBA	molecular function
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	IDA	biological process
GO:0016075	rRNA catabolic process	IDA	biological process
GO:0008408	3'-5' exonuclease activity	IDA	molecular function
GO:0008409	5'-3' exonuclease activity	IDA	molecular function
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	IEA	biological process
GO:0008408	3'-5' exonuclease activity	IEA	molecular function
GO:0008409	5'-3' exonuclease activity	IEA	molecular function
GO:0004518	nuclease activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004527	exonuclease activity	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881