• Gene id: 78990

Gene Summary

• Gene Symbol: OTUB2   Gene   UCSC   Ensembl
• Aliases: C14orf137, OTB2, OTU2
• Gene name: OTU deubiquitinase, ubiquitin aldehyde binding 2
• Alternate names: ubiquitin thioesterase OTUB2, OTU domain, ubiquitin aldehyde binding 2, OTU domain-containing ubiquitin aldehyde-binding protein 2, deubiquitinating enzyme OTUB2, otubain-2, ubiquitin-specific protease otubain 2, ubiquitin-specific-processing protease OTUB2,
• Gene location: 14q32.12 (94026339: 94048929)     Exons: 19     NC_000014.9
• Gene summary(Entrez): This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (
• OMIM: 608338

Protein Summary

• Protein general information: Q96DC9  
  • Name: Ubiquitin thioesterase OTUB2 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB2) (OTU domain containing ubiquitin aldehyde binding protein 2) (Otubain 2) (Ubiquitin specific processing protease OTUB2)
  • Length: 234  
  • Mass: 27213
  • Tissue specificity: Widely expressed. Expressed at higher level in brain. {ECO
• Sequence:

  MSETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAIRKTKGDGNCFYRALGYSYLESLLGKSREIFKFK
  ERVLQTPNDLLAAGFEEHKFRNFFNAFYSVVELVEKDGSVSSLLKVFNDQSASDHIVQFLRLLTSAFIRNRADFF
  RHFIDEEMDIKDFCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDTALNHHVFPEAATPSVYLLYKTSHY
  NILYAADKH

• Structural information:
  • Protein Domains: (40..23-)
    (/note="OTU-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00139"-)
  • Interpro: IPR003323  IPR030299  IPR016615  IPR038765  IPR019400   IPR042468  IPR042467  
  • Prosite: PS50802
  • PDB: 1TFF 4FJV 5QIO 5QIP 5QIQ 5QIR 5QIS 5QIT 5QIU 5QIV 5QIW 5QIX 5QIY 5QIZ
  • PDBsum: 1TFF 4FJV 5QIO 5QIP 5QIQ 5QIR 5QIS 5QIT 5QIU 5QIV 5QIW 5QIX 5QIY 5QIZ
  • STRING: ENSP00000203664
• Other Databases: GeneCards:  OTUB2  Malacards:  OTUB2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004843	thiol-dependent ubiquitin-specific protease activity	IBA	molecular function
GO:0035871	protein K11-linked deubiquitination	IBA	biological process
GO:0070536	protein K63-linked deubiquitination	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0019784	NEDD8-specific protease activity	IBA	molecular function
GO:0043130	ubiquitin binding	IBA	molecular function
GO:0071108	protein K48-linked deubiquitination	IBA	biological process
GO:0070536	protein K63-linked deubiquitination	IDA	biological process
GO:0070536	protein K63-linked deubiquitination	IDA	biological process
GO:0035871	protein K11-linked deubiquitination	IDA	biological process
GO:0004843	thiol-dependent ubiquitin-specific protease activity	IDA	molecular function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	IDA	molecular function
GO:0071108	protein K48-linked deubiquitination	IDA	biological process
GO:0071108	protein K48-linked deubiquitination	IDA	biological process
GO:0004843	thiol-dependent ubiquitin-specific protease activity	IMP	molecular function
GO:0016579	protein deubiquitination	IMP	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016579	protein deubiquitination	IEA	biological process
GO:0008233	peptidase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008234	cysteine-type peptidase activity	IEA	molecular function
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Non obstructive azoospermia	MIK: 24012201
Sertoli cell only syndrome	MIK: 23869807
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq