• Gene id: 78986

Gene Summary

• Gene Symbol: DUSP26   Gene   UCSC   Ensembl
• Aliases: DSP-4, DUSP24, LDP-4, LDP4, MKP-8, MKP8, NATA1, NEAP, SKRP3
• Gene name: dual specificity phosphatase 26
• Alternate names: dual specificity protein phosphatase 26, MAP kinase phosphatase 8, Novel amplified gene in thyroid anaplastic cancer, dual specificity phosphatase 26 (putative), dual specificity phosphatase SKRP3, low-molecular-mass dual-specificity phosphatase 4, mitogen-acti,
• Gene location: 8p12 (33600105: 33591329)     Exons: 4     NC_000008.11
• Gene summary(Entrez): This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene dependi
• OMIM: 611665

Protein Summary

• Protein general information: Q9BV47  
  • Name: Dual specificity protein phosphatase 26 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase SKRP3) (Low molecular mass dual specificity phosphatase 4) (DSP 4) (LDP 4) (Mitogen activated protein kinase phosphatase 8) (MAP kinase phosphatase 8) (MKP 8
  • Length: 211  
  • Mass: 23946
  • Tissue specificity: Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer. {ECO
• Sequence:

  MCPGNWLWASMTFMARFSRSSSRSPVRTRGTLEEMPTVQHPFLNVFELERLLYTGKTACNHADEVWPGLYLGDQD
  MANNRRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEAHDSPAFDMSIHFQTAADFIHRALSQPGGKILV
  HCAVGVSRSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNRGFLRQLLALDRRLRQGLEA

• Structural information:
  • Protein Domains: (61..20-)
    (/note="Tyrosine-protein-phosphatase")
  • Interpro: IPR020417  IPR020405  IPR000340  IPR029021  IPR016130   IPR000387  IPR020422  
  • Prosite: PS00383 PS50056 PS50054
  • PDB: 2E0T 4B04 4HRF 5GTJ
  • PDBsum: 2E0T 4B04 4HRF 5GTJ
  • STRING: ENSP00000256261
• Other Databases: GeneCards:  DUSP26  Malacards:  DUSP26

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004725	protein tyrosine phosphatase activity	IEA	molecular function
GO:0006470	protein dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEA	molecular function
GO:0016791	phosphatase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0004725	protein tyrosine phosphatase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process
GO:1902310	positive regulation of peptidyl-serine dephosphorylation	IDA	biological process
GO:0006470	protein dephosphorylation	IDA	biological process
GO:0006470	protein dephosphorylation	IDA	biological process
GO:0005794	Golgi apparatus	IDA	cellular component
GO:0070373	negative regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	biological process
GO:0004721	phosphoprotein phosphatase activity	IDA	molecular function
GO:0004647	phosphoserine phosphatase activity	IDA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	IMP	biological process
GO:0004725	protein tyrosine phosphatase activity	IMP	molecular function
GO:0004647	phosphoserine phosphatase activity	IMP	molecular function
GO:0045785	positive regulation of cell adhesion	IMP	biological process
GO:0001102	RNA polymerase II activating transcription factor binding	IPI	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0002039	p53 binding	IPI	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq