• Gene id: 7862

Gene Summary

• Gene Symbol: BRPF1   Gene   UCSC   Ensembl
• Aliases: BR140, IDDDFP
• Gene name: bromodomain and PHD finger containing 1
• Alternate names: peregrin, bromodomain-containing protein, 140kD,
• Gene location: 3p25.3 (9731728: 9748014)     Exons: 16     NC_000003.12
• Gene summary(Entrez): This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. T
• OMIM: 602410

Protein Summary

• Protein general information: P55201  
  • Name: Peregrin (Bromodomain and PHD finger containing protein 1) (Protein Br140)
  • Length: 1214  
  • Mass: 137499
  • Tissue specificity: High levels in testis. {ECO
• Sequence:

  MGVDFDVKTFCHNLRATKPPYECPVETCRKVYKSYSGIEYHLYHYDHDNPPPPQQTPLRKHKKKGRQSRPANKQS
  PSPSEVSQSPGREVMSYAQAQRMVEVDLHGRVHRISIFDNLDVVSEDEEAPEEAPENGSNKENTETPAATPKSGK
  HKNKEKRKDSNHHHHHNVSASTTPKLPEVVYRELEQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDMDEEDYIWL
  DIMNERRKTEGVSPIPQEIFEYLMDRLEKESYFESHNKGDPNALVDEDAVCCICNDGECQNSNVILFCDMCNLAV
  HQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPNKGGAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIE
  HIPPARWKLTCYICKQRGSGACIQCHKANCYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIHTPP
  GSARRLPALSHSEGEEDEDEEEDEGKGWSSEKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVPCIPPHRLSKIT
  NRLTIQRKSQFMQRLHSYWTLKRQSRNGVPLLRRLQTHLQSQRNCDQVGRDSEDKNWALKEQLKSWQRLRHDLER
  ARLLVELIRKREKLKRETIKVQQIAMEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDF
  FTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAVLRQARRQAEKMGIDFETGMHIP
  HSLAGDEATHHTEDAAEEERLVLLENQKHLPVEEQLKLLLERLDEVNASKQSVGRSRRAKMIKKEMTALRRKLAH
  QRETGRDGPERHGPSSRGSLTPHPAACDKDGQTDSAAEESSSQETSKGLGPNMSSTPAHEVGRRTSVLFSKKNPK
  TAGPPKRPGRPPKNRESQMTPSHGGSPVGPPQLPIMSSLRQRKRGRSPRPSSSSDSDSDKSTEDPPMDLPANGFS
  GGNQPVKKSFLVYRNDCSLPRSSSDSESSSSSSSSAASDRTSTTPSKQGRGKPSFSRGTFPEDSSEDTSGTENEA
  YSVGTGRGVGHSMVRKSLGRGAGWLSEDEDSPLDALDLVWAKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPL
  EVLKLGEQMTQEAREHLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLDKEKMLEGRKSNIRKSVQIAYHRALQHRS
  KVQGEQSSETSDSD

• Structural information:
  • Protein Domains: (645..71-)
    (/note="Bromo-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00035-)
    (1085..116-)
    (/note="PWWP-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00162"-)
  • Interpro: IPR035502  IPR001487  IPR036427  IPR018359  IPR042008   IPR019542  IPR034732  IPR042061  IPR000313  IPR019786  IPR013087  IPR011011  IPR001965  IPR019787  IPR013083  
  • Prosite: PS00633 PS50014 PS51805 PS50812 PS01359 PS50016 PS00028 PS50157
  • CDD: cd05839 cd15701 cd15676
  • PDB: 2D9E 2RS9 2X35 2X4W 2X4X 2X4Y 3L42 3MO8 4LC2 4QYD 4QYL 4UYE 5C6S 5C7N 5C85 5C87 5C89 5D7X 5DY7 5DYA 5DYC 5E3D 5E3G 5EM3 5EPR 5EPS 5EQ1 5ERC 5ETB 5ETD 5EV9 5EVA 5EWC 5EWD 5EWH 5EWV 5EWW 5FFV 5FFW 5FFY 5FG4 5FG5 5G4R 5G4S 5MWG 5MWH 5MWZ 5MYG 5O4S 5O4T 5O55 5O5A 5O5F 5O5H 5OV8 5OWA 5OWB 5OWE 5T4U 5T4V 6EKQ 6U04
  • PDBsum: 2D9E 2RS9 2X35 2X4W 2X4X 2X4Y 3L42 3MO8 4LC2 4QYD 4QYL 4UYE 5C6S 5C7N 5C85 5C87 5C89 5D7X 5DY7 5DYA 5DYC 5E3D 5E3G 5EM3 5EPR 5EPS 5EQ1 5ERC 5ETB 5ETD 5EV9 5EVA 5EWC 5EWD 5EWH 5EWV 5EWW 5FFV 5FFW 5FFY 5FG4 5FG5 5G4R 5G4S 5MWG 5MWH 5MWZ 5MYG 5O4S 5O4T 5O55 5O5A 5O5F 5O5H 5OV8 5OWA 5OWB 5OWE 5T4U 5T4V 6EKQ 6U04
  • DIP: 59001
  • STRING: ENSP00000373340
• Other Databases: GeneCards:  BRPF1  Malacards:  BRPF1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0045893	positive regulation of transcription, DNA-templated	IDA	biological process
GO:0070776	MOZ/MORF histone acetyltransferase complex	IDA	cellular component
GO:0070776	MOZ/MORF histone acetyltransferase complex	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0043994	histone acetyltransferase activity (H3-K23 specific)	IDA	contributes to
GO:0070776	MOZ/MORF histone acetyltransferase complex	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0044154	histone H3-K14 acetylation	IDA	biological process
GO:0000123	histone acetyltransferase complex	IDA	cellular component
GO:0043972	histone H3-K23 acetylation	IMP	biological process
GO:0006325	chromatin organization	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0005694	chromosome	IEA	cellular component
GO:1901796	regulation of signal transduction by p53 class mediator	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005694	chromosome	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0043966	histone H3 acetylation	IDA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)