• Gene id: 7812

Gene Summary

• Gene Symbol: CSDE1   Gene   UCSC   Ensembl
• Aliases: D1S155E, UNR
• Gene name: cold shock domain containing E1
• Alternate names: cold shock domain-containing protein E1, N-ras upstream gene protein, NRAS-related, cold shock domain containing E1, RNA binding, upstream of NRAS,
• Gene location: 1p13.2 (114758049: 114716912)     Exons: 21     NC_000001.11
• OMIM: 191510

Protein Summary

• Protein general information: O75534  
  • Name: Cold shock domain containing protein E1 (N ras upstream gene protein) (Protein UNR)
  • Length: 798  
  • Mass: 88885
• Sequence:

  MSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSS
  DRRTGKPIAVKLVKIKQEILPEERMNGQVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTPEDVEGNV
  QLETGDKINFVIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQP
  GDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPFG
  DKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDVRMFFH
  FSEILDGNQLHIADEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGK
  EKEAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVAT
  LKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSLSKGKGNKVSAEKVNKTHSVNGITEEADPTIYSGK
  VIRPLRSVDPTQTEYQGMIEIVEEGDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRR
  ATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCEGPKAVAAPRP
  DRLVNRLKNITLDDASAPRLMVLRQPRGPDNSMGFGAERKIRQAGVID

• Structural information:
  • Protein Domains: (26..8-)
    (/note="CSD-1)
    (136..17-)
    (/note="CSD-)
    (-)
    (186..24-)
    (/note="CSD-3)
    (297..33-)
    (/note="CSD-)
    (-)
    (349..41-)
    (/note="CSD-5)
    (447..50-)
    (/note="CSD-6)
    (519..57-)
    (/note="CSD-7)
    (-)
  • Interpro: IPR011129  IPR019844  IPR002059  IPR012340  IPR024642  
  • Prosite: PS00352 PS51857
  • CDD: cd04458
  • PDB: 1WFQ 1X65 2YTV 2YTX 2YTY
  • PDBsum: 1WFQ 1X65 2YTV 2YTX 2YTY
  • STRING: ENSP00000481762
• Other Databases: GeneCards:  CSDE1  Malacards:  CSDE1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0070937	CRD-mediated mRNA stability complex	IDA	cellular component
GO:0034063	stress granule assembly	IMP	biological process
GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay	IMP	biological process
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0008584	male gonad development	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0010494	cytoplasmic stress granule	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005794	Golgi apparatus	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881