Gene id |
7782 |
Gene Summary Protein Summary Gene ontology Diseases PubMed |
Gene Summary
|
Gene Symbol |
SLC30A4 Gene UCSC Ensembl |
Aliases |
ZNT4, znT-4 |
Gene name |
solute carrier family 30 member 4 |
Alternate names |
zinc transporter 4, solute carrier family 30 (zinc transporter), member 4, |
Gene location |
15q21.1 (45523754: 45479605) Exons: 11 NC_000015.10
|
Gene summary(Entrez) |
Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypept
|
OMIM |
179605 |
Protein Summary
|
Protein general information
| O14863
Name: Zinc transporter 4 (ZnT 4) (Solute carrier family 30 member 4)
Length: 429 Mass: 47483
|
Sequence |
MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEAGDEGLSRFNKLRVVVADDGSEAPERPVNGAHPTLQADDDS LLDQDLPLTNSQLSLKVDSCDNCSKQREILKQRKVKARLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTD LSAIILTLLALWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQRTIHMNYEINGDIMLITAAVG VAVNVIMGFLLNQSGHRHSHSHSLPSNSPTRGSGCERNHGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPE YKIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKEALMKIEDVYSVEDLNIWSLTSGKSTAIVH IQLIPGSSSKWEEVQSKANHLLLNTFGMYRCTIQLQSYRQEVDRTCANCQSSSP
|
Structural information |
|
Other Databases |
GeneCards: SLC30A4 Malacards: SLC30A4 |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:0010043 |
response to zinc ion
|
IBA |
biological process |
GO:0061088 |
regulation of sequesterin g of zinc ion
|
IBA |
biological process |
GO:0071577 |
zinc ion transmembrane tr ansport
|
IBA |
biological process |
GO:0005385 |
zinc ion transmembrane tr ansporter activity
|
IBA |
molecular function |
GO:0005886 |
plasma membrane
|
IBA |
cellular component |
GO:0006812 |
cation transport
|
IEA |
biological process |
GO:0008324 |
cation transmembrane tran sporter activity
|
IEA |
molecular function |
GO:0016021 |
integral component of mem brane
|
IEA |
cellular component |
GO:0055085 |
transmembrane transport
|
IEA |
biological process |
GO:0005764 |
lysosome
|
IEA |
cellular component |
GO:0005768 |
endosome
|
IEA |
cellular component |
GO:0006811 |
ion transport
|
IEA |
biological process |
GO:0006829 |
zinc ion transport
|
IEA |
biological process |
GO:0016021 |
integral component of mem brane
|
IEA |
cellular component |
GO:0016020 |
membrane
|
IEA |
cellular component |
GO:0005385 |
zinc ion transmembrane tr ansporter activity
|
TAS |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0055069 |
zinc ion homeostasis
|
IEA |
biological process |
GO:0061088 |
regulation of sequesterin g of zinc ion
|
IDA |
biological process |
GO:0005737 |
cytoplasm
|
IDA |
cellular component |
GO:0005770 |
late endosome
|
IDA |
cellular component |
GO:0031902 |
late endosome membrane
|
IEA |
cellular component |
GO:0005765 |
lysosomal membrane
|
IEA |
cellular component |
GO:0010008 |
endosome membrane
|
IEA |
cellular component |
GO:0009636 |
response to toxic substan ce
|
IDA |
biological process |
|
|
Associated diseases |
References |
prostate carcinoma in situ | PMID:12955079 |
Spermatogenic defects | MIK: 31037746 |
Unexplained infertility | MIK: 25753583 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
31037746 |
Spermatoge nic defect s
|
|
|
16 (1 control, 15 cases)
|
Male infertility |
GSE6023 analyzed using GEO2R
|
Show abstract |
25753583 |
Unexplaine d infertil ity
|
|
|
46 (17 fertile men, 29 male pa tients)
|
Male infertility |
Microarray
|
Show abstract |
|