• Gene id: 7763

Gene Summary

• Gene Symbol: ZFAND5   Gene   UCSC   Ensembl
• Aliases: ZA20D2, ZFAND5A, ZNF216
• Gene name: zinc finger AN1-type containing 5
• Alternate names: AN1-type zinc finger protein 5, zinc finger A20 domain-containing protein 2, zinc finger protein 216, zinc finger, A20 domain containing 2, zinc finger, AN1-type domain 5,
• Gene location: 9q21.13 (72365207: 72351412)     Exons: 8     NC_000009.12
• OMIM: 604761

Protein Summary

• Protein general information: O76080  
  • Name: AN1 type zinc finger protein 5 (Zinc finger A20 domain containing protein 2) (Zinc finger protein 216)
  • Length: 213  
  • Mass: 23132
  • Tissue specificity: Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable
• Sequence:

  MAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQNSGRMSPMGTASGSNSPTSDSASVQRADTSLNN
  CEGAAGSTSEKSRNVPVAALPVTQQMTEMSISREDKITTPKTEVSEPVVTQPSPSVSQPSTSQSEEKAPELPKPK
  KNRCFMCRKKVGLTGFDCRCGNLFCGLHRYSDKHNCPYDYKAEAAAKIRKENPVVVAEKIQRI

• Structural information:
  • Interpro: IPR035896  IPR002653  IPR000058  
  • Prosite: PS51036 PS51039
  • STRING: ENSP00000237937
• Other Databases: GeneCards:  ZFAND5  Malacards:  ZFAND5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008270	zinc ion binding	IEA	molecular function
GO:0003677	DNA binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0001944	vasculature development	IEA	biological process
GO:0003016	respiratory system process	IEA	biological process
GO:0010761	fibroblast migration	IEA	biological process
GO:0048705	skeletal system morphogenesis	IEA	biological process
GO:0048745	smooth muscle tissue development	IEA	biological process
GO:0060324	face development	IEA	biological process
GO:0001701	in utero embryonic development	IEA	biological process
GO:0048008	platelet-derived growth factor receptor signaling pathway	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0008150	biological_process	ND	biological process
GO:0005575	cellular_component	ND	cellular component
GO:0003674	molecular_function	ND	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)