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Gene id 7533
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol YWHAH   Gene   UCSC   Ensembl
Aliases YWHA1
Gene name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Alternate names 14-3-3 protein eta, 14-3-3 eta, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide,
Gene location 22q12.3 (31944534: 31957602)     Exons: 2     NC_000022.11
Gene summary(Entrez) This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to th
OMIM 113508

Protein Summary
Protein general information Q04917  

Name: 14 3 3 protein eta (Protein AS1)

Length: 246  Mass: 28219

Tissue specificity: Expressed mainly in the brain and present in other tissues albeit at lower levels.

Sequence MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGN
EKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEAS
EAAYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQL
LRDNLTLWTSDQQDEEAGEGN
Structural information
Interpro:  IPR000308  IPR023409  IPR036815  IPR023410  
Prosite:   PS00796 PS00797

PDB:  		 2C63 2C74
PDBsum:   2C63 2C74

DIP:  
27566
MINT:  
STRING:   ENSP00000248975
Other Databases GeneCards:  YWHAH  Malacards:  YWHAH

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:1900740 positive regulation of pr
otein insertion into mito
chondrial membrane involv
ed in apoptotic signaling
pathway
 TAS biological process
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0005829 cytosol
 TAS cellular component
GO:0061024 membrane organization
 TAS biological process
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0003779 actin binding
 IEA molecular function
GO:0044325 ion channel binding
 IEA molecular function
GO:0005737 cytoplasm
 IEA cellular component
GO:0006886 intracellular protein tra
nsport
 IEA biological process
GO:0019904 protein domain specific b
inding
 IEA molecular function
GO:0050774 negative regulation of de
ndrite morphogenesis
 IEA biological process
GO:0017080 sodium channel regulator
activity
 IDA molecular function
GO:0044325 ion channel binding
 IPI molecular function
GO:0044325 ion channel binding
 IPI molecular function
GO:0019899 enzyme binding
 IPI molecular function
GO:0046982 protein heterodimerizatio
n activity
 IPI molecular function
GO:0005886 plasma membrane
 IDA cellular component
GO:0086010 membrane depolarization d
uring action potential
 IDA biological process
GO:0002028 regulation of sodium ion
transport
 IDA biological process
GO:0014704 intercalated disc
 IC cellular component
GO:2000649 regulation of sodium ion
transmembrane transporter
activity
 IDA biological process
GO:0005739 mitochondrion
 IEA cellular component
GO:0045893 positive regulation of tr
anscription, DNA-template
d
 IDA biological process
GO:0006713 glucocorticoid catabolic
process
 IDA biological process
GO:0042921 glucocorticoid receptor s
ignaling pathway
 IDA biological process
GO:0021762 substantia nigra developm
ent
 HEP biological process
GO:0070062 extracellular exosome
 HDA cellular component
GO:0048167 regulation of synaptic pl
asticity
 ISS biological process
GO:0070062 extracellular exosome
 HDA cellular component
GO:0070062 extracellular exosome
 HDA cellular component
GO:0050774 negative regulation of de
ndrite morphogenesis
 ISS biological process
GO:0019904 protein domain specific b
inding
 ISS molecular function
GO:0005737 cytoplasm
 ISS cellular component
GO:0005159 insulin-like growth facto
r receptor binding
 ISS molecular function
GO:0045664 regulation of neuron diff
erentiation
 ISS biological process
GO:0035259 glucocorticoid receptor b
inding
 IPI molecular function
GO:0006886 intracellular protein tra
nsport
 ISS biological process

KEGG pathways

Expand All | Collapse All

Pathway idPathway name
hsa04151PI3K-Akt signaling pathway
hsa05203Viral carcinogenesis
hsa04390Hippo signaling pathway
hsa05160Hepatitis C
hsa04110Cell cycle
hsa04114Oocyte meiosis

Diseases

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Associated diseases References
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia
13 (5 controls,
8 cases)
 Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract