• Gene id: 7473

Gene Summary

• Gene Symbol: WNT3   Gene   UCSC   Ensembl
• Aliases: INT4, TETAMS
• Gene name: Wnt family member 3
• Alternate names: proto-oncogene Wnt-3, WNT-3 proto-oncogene protein, proto-oncogene Int-4 homolog, wingless-type MMTV integration site family, member 3,
• Gene location: 17q21.31-q21.32 (46818691: 46762505)     Exons: 5     NC_000017.11
• Gene summary(Entrez): The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryog
• OMIM: 604663

Protein Summary

• Protein general information: P56703  
  • Name: Proto oncogene Wnt 3 (Proto oncogene Int 4 homolog)
  • Length: 355  
  • Mass: 39645
• Sequence:

  MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKL
  GIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPG
  EGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQP
  DFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTC
  NVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK

• Structural information:
  • Interpro: IPR005817  IPR009141  IPR018161  
  • Prosite: PS00246
  • PDB: 6AHY
  • PDBsum: 6AHY
  • STRING: ENSP00000225512
• Other Databases: GeneCards:  WNT3  Malacards:  WNT3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0048018	receptor ligand activity	IDA	molecular function
GO:1990909	Wnt signalosome	IC	cellular component
GO:0010628	positive regulation of gene expression	IDA	biological process
GO:1990909	Wnt signalosome	NAS	cellular component
GO:0072089	stem cell proliferation	IMP	biological process
GO:1905474	canonical Wnt signaling pathway involved in stem cell proliferation	IDA	biological process
GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	IMP	biological process
GO:0050767	regulation of neurogenesis	IMP	biological process
GO:0060070	canonical Wnt signaling pathway	TAS	biological process
GO:0045165	cell fate commitment	IBA	biological process
GO:0005615	extracellular space	IBA	cellular component
GO:0005125	cytokine activity	IBA	molecular function
GO:0060070	canonical Wnt signaling pathway	IBA	biological process
GO:0030182	neuron differentiation	IBA	biological process
GO:0005109	frizzled binding	IBA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0016055	Wnt signaling pathway	IEA	biological process
GO:0005102	signaling receptor binding	IEA	molecular function
GO:0007275	multicellular organism development	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0016055	Wnt signaling pathway	IEA	biological process
GO:0007275	multicellular organism development	IEA	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0016055	Wnt signaling pathway	TAS	biological process
GO:0030666	endocytic vesicle membrane	TAS	cellular component
GO:0030666	endocytic vesicle membrane	TAS	cellular component
GO:0070062	extracellular exosome	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0048018	receptor ligand activity	IDA	molecular function
GO:0060070	canonical Wnt signaling pathway	IDA	biological process
GO:0007276	gamete generation	IEA	biological process
GO:0009950	dorsal/ventral axis specification	IEA	biological process
GO:0009952	anterior/posterior pattern specification	IEA	biological process
GO:0010628	positive regulation of gene expression	IEA	biological process
GO:0030177	positive regulation of Wnt signaling pathway	IEA	biological process
GO:0031012	extracellular matrix	IEA	cellular component
GO:0048646	anatomical structure formation involved in morphogenesis	IEA	biological process
GO:0048697	positive regulation of collateral sprouting in absence of injury	IEA	biological process
GO:0060064	Spemann organizer formation at the anterior end of the primitive streak	IEA	biological process
GO:0060323	head morphogenesis	IEA	biological process
GO:0001707	mesoderm formation	IEA	biological process
GO:0007411	axon guidance	IEA	biological process
GO:0009948	anterior/posterior axis specification	IEA	biological process
GO:0019904	protein domain specific binding	IEA	molecular function
GO:0035115	embryonic forelimb morphogenesis	IEA	biological process
GO:0035116	embryonic hindlimb morphogenesis	IEA	biological process
GO:0048843	negative regulation of axon extension involved in axon guidance	IEA	biological process
GO:0060070	canonical Wnt signaling pathway	IEA	biological process
GO:0060173	limb development	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0048018	receptor ligand activity	IC	molecular function
GO:0005109	frizzled binding	IPI	molecular function
GO:0000902	cell morphogenesis	IMP	biological process
GO:0005615	extracellular space	TAS	cellular component
GO:0060174	limb bud formation	IMP	biological process
GO:0060070	canonical Wnt signaling pathway	IDA	biological process
GO:0060070	canonical Wnt signaling pathway	IDA	biological process
GO:0044338	canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation	IMP	biological process
GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation	IMP	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0060070	canonical Wnt signaling pathway	IDA	biological process
GO:0071300	cellular response to retinoic acid	ISS	biological process
GO:0030182	neuron differentiation	ISS	biological process
GO:0005109	frizzled binding	IPI	molecular function
GO:0061180	mammary gland epithelium development	IEP	biological process

KEGG pathways

Pathway id	Pathway name
hsa05200	Pathways in cancer
hsa05010	Alzheimer disease
hsa05165	Human papillomavirus infection
hsa05206	MicroRNAs in cancer
hsa05205	Proteoglycans in cancer
hsa04310	Wnt signaling pathway
hsa04150	mTOR signaling pathway
hsa04390	Hippo signaling pathway
hsa05225	Hepatocellular carcinoma
hsa04934	Cushing syndrome
hsa05226	Gastric cancer
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa05224	Breast cancer
hsa04916	Melanogenesis
hsa05217	Basal cell carcinoma

Diseases

Associated diseases	References
Tetra-amelia	KEGG:H00636
Tetra-amelia	KEGG:H00636
Breast cancer	PMID:11604997
Endometrial carcinoma	PMID:9099960
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq