• Gene id: 746

Gene Summary

• Gene Symbol: TMEM258   Gene   UCSC   Ensembl
• Aliases: C11orf10, Kud, Kuduk
• Gene name: transmembrane protein 258
• Alternate names: transmembrane protein 258, UPF0197 transmembrane protein C11orf10, dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258, oligosaccharyl transferase subunit TMEM258,
• Gene location: 11q12.2 (61792598: 61788948)     Exons: 4     NC_000011.10
• OMIM: 617615

Protein Summary

• Protein general information: P61165  
  • Name: Transmembrane protein 258 (Dolichyl diphosphooligosaccharide protein glycosyltransferase subunit TMEM258) (Oligosaccharyl transferase subunit TMEM258)
  • Length: 79  
  • Mass: 9079
  • Tissue specificity: Ubiquitously expressed. {ECO
• Sequence:

  MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWV
  GIYV

• Structural information:
  • Interpro: IPR007915  
  • PDB: 6S7O 6S7T
  • PDBsum: 6S7O 6S7T
  • STRING: ENSP00000443216
• Other Databases: GeneCards:  TMEM258  Malacards:  TMEM258

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0043227	membrane-bounded organelle	IBA	cellular component
GO:0032991	protein-containing complex	IBA	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0034998	oligosaccharyltransferase I complex	IDA	cellular component
GO:0006487	protein N-linked glycosylation	IMP	biological process
GO:0006487	protein N-linked glycosylation	IEA	biological process
GO:0034998	oligosaccharyltransferase I complex	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0006486	protein glycosylation	IEA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)