• Gene id: 7442

Gene Summary

• Gene Symbol: TRPV1   Gene   UCSC   Ensembl
• Aliases: VR1
• Gene name: transient receptor potential cation channel subfamily V member 1
• Alternate names: transient receptor potential cation channel subfamily V member 1, OTRPC1, capsaicin receptor, osm-9-like TRP channel 1, transient receptor potential vanilloid 1a, transient receptor potential vanilloid 1b, vanilloid receptor subtype 1,
• Gene location: 17p13.2 (3609410: 3565445)     Exons: 19     NC_000017.11
• Gene summary(Entrez): Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a r
• OMIM: 602076

Protein Summary

• Protein general information: Q8NER1  
  • Name: Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm 9 like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)
  • Length: 839  
  • Mass: 94956
  • Tissue specificity: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum o
• Sequence:

  MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFPVDCPHEEGELDSCPT
  ITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFK
  DPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENG
  ADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA
  DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAY
  GPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFT
  MAAYYRPVDGLPPFKMEKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLA
  TVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE
  DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILL
  LNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNW
  TTWNTNVGIINEDPGNCEGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPE
  DAEVFKSPAASGEK

• Structural information:
  • Interpro: IPR002110  IPR020683  IPR036770  IPR005821  IPR024862   IPR024863  IPR008347  
  • Prosite: PS50297 PS50088
  • STRING: ENSP00000461007
• Other Databases: GeneCards:  TRPV1  Malacards:  TRPV1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005262	calcium channel activity	IBA	molecular function
GO:0005216	ion channel activity	IBA	molecular function
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0098703	calcium ion import across plasma membrane	IBA	biological process
GO:0005230	extracellular ligand-gated ion channel activity	IDA	molecular function
GO:0034605	cellular response to heat	IDA	biological process
GO:0098703	calcium ion import across plasma membrane	IDA	biological process
GO:0071468	cellular response to acidic pH	IDA	biological process
GO:0071318	cellular response to ATP	ISS	biological process
GO:0071312	cellular response to alkaloid	ISS	biological process
GO:0005231	excitatory extracellular ligand-gated ion channel activity	ISS	molecular function
GO:1901594	response to capsazepine	ISS	biological process
GO:0051289	protein homotetramerization	ISS	biological process
GO:1901594	response to capsazepine	IMP	biological process
GO:0005516	calmodulin binding	ISS	molecular function
GO:0070588	calcium ion transmembrane transport	ISS	biological process
GO:0045211	postsynaptic membrane	ISS	cellular component
GO:0031226	intrinsic component of plasma membrane	ISS	cellular component
GO:0015278	calcium-release channel activity	ISS	molecular function
GO:0005524	ATP binding	ISS	molecular function
GO:0004888	transmembrane signaling receptor activity	ISS	molecular function
GO:0005887	integral component of plasma membrane	ISS	cellular component
GO:0035091	phosphatidylinositol binding	ISS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005216	ion channel activity	IEA	molecular function
GO:0006811	ion transport	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0055085	transmembrane transport	IEA	biological process
GO:0042995	cell projection	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0006816	calcium ion transport	IEA	biological process
GO:0005262	calcium channel activity	IEA	molecular function
GO:0005516	calmodulin binding	IEA	molecular function
GO:0045202	synapse	IEA	cellular component
GO:0045211	postsynaptic membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0070588	calcium ion transmembrane transport	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0006811	ion transport	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0005262	calcium channel activity	TAS	molecular function
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0007635	chemosensory behavior	TAS	biological process
GO:0050955	thermoception	IDA	biological process
GO:0016021	integral component of membrane	IDA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0070588	calcium ion transmembrane transport	TAS	biological process
GO:1990090	cellular response to nerve growth factor stimulus	IEA	biological process
GO:1901594	response to capsazepine	IEA	biological process
GO:0071363	cellular response to growth factor stimulus	IEA	biological process
GO:0071356	cellular response to tumor necrosis factor	IEA	biological process
GO:0071318	cellular response to ATP	IEA	biological process
GO:0071312	cellular response to alkaloid	IEA	biological process
GO:0051289	protein homotetramerization	IEA	biological process
GO:0034605	cellular response to heat	IEA	biological process
GO:0030425	dendrite	IEA	cellular component
GO:0017081	chloride channel regulator activity	IEA	molecular function
GO:0015276	ligand-gated ion channel activity	IEA	molecular function
GO:0014047	glutamate secretion	IEA	biological process
GO:0010917	negative regulation of mitochondrial membrane potential	IEA	biological process
GO:0009408	response to heat	IEA	biological process
GO:0009268	response to pH	IEA	biological process
GO:0006816	calcium ion transport	IEA	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0005516	calmodulin binding	IEA	molecular function
GO:0005261	cation channel activity	IEA	molecular function
GO:0005231	excitatory extracellular ligand-gated ion channel activity	IEA	molecular function
GO:0005230	extracellular ligand-gated ion channel activity	IEA	molecular function
GO:0003085	negative regulation of systemic arterial blood pressure	IEA	biological process
GO:0060083	smooth muscle contraction involved in micturition	IEA	biological process
GO:0050960	detection of temperature stimulus involved in thermoception	IEA	biological process
GO:0050954	sensory perception of mechanical stimulus	IEA	biological process
GO:0043005	neuron projection	IEA	cellular component
GO:0010243	response to organonitrogen compound	IEA	biological process
GO:0009408	response to heat	IEA	biological process
GO:0009268	response to pH	IEA	biological process
GO:0006816	calcium ion transport	IEA	biological process
GO:0005262	calcium channel activity	IEA	molecular function
GO:0002790	peptide secretion	IEA	biological process
GO:0002024	diet induced thermogenesis	IEA	biological process
GO:0001660	fever generation	IEA	biological process
GO:0098703	calcium ion import across plasma membrane	IEA	biological process
GO:0090212	negative regulation of establishment of blood-brain barrier	IEA	biological process
GO:0071502	cellular response to temperature stimulus	IEA	biological process
GO:0071468	cellular response to acidic pH	IEA	biological process
GO:0071345	cellular response to cytokine stimulus	IEA	biological process
GO:0070588	calcium ion transmembrane transport	IEA	biological process
GO:0060454	positive regulation of gastric acid secretion	IEA	biological process
GO:0045429	positive regulation of nitric oxide biosynthetic process	IEA	biological process
GO:0045211	postsynaptic membrane	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0043434	response to peptide hormone	IEA	biological process
GO:0043065	positive regulation of apoptotic process	IEA	biological process
GO:0043025	neuronal cell body	IEA	cellular component
GO:0042802	identical protein binding	IEA	molecular function
GO:0035091	phosphatidylinositol binding	IEA	molecular function
GO:0031226	intrinsic component of plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0015278	calcium-release channel activity	IEA	molecular function
GO:0010459	negative regulation of heart rate	IEA	biological process
GO:0009897	external side of plasma membrane	IEA	cellular component
GO:0008324	cation transmembrane transporter activity	IEA	molecular function
GO:0007204	positive regulation of cytosolic calcium ion concentration	IEA	biological process
GO:0006954	inflammatory response	IEA	biological process
GO:0005887	integral component of plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0004888	transmembrane signaling receptor activity	IEA	molecular function
GO:0001774	microglial cell activation	IEA	biological process
GO:0097603	temperature-gated ion channel activity	IEA	molecular function
GO:0050968	detection of chemical stimulus involved in sensory perception of pain	IEA	biological process
GO:0050965	detection of temperature stimulus involved in sensory perception of pain	IEA	biological process
GO:0048266	behavioral response to pain	IEA	biological process
GO:0048265	response to pain	IEA	biological process
GO:0034220	ion transmembrane transport	IEA	biological process
GO:0019233	sensory perception of pain	IEA	biological process
GO:0014832	urinary bladder smooth muscle contraction	IEA	biological process
GO:0006629	lipid metabolic process	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0001659	temperature homeostasis	IEA	biological process
GO:0000122	negative regulation of transcription by RNA polymerase II	IEA	biological process
GO:0032591	dendritic spine membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0045211	postsynaptic membrane	IEA	cellular component
GO:0060079	excitatory postsynaptic potential	IEA	biological process
GO:0060079	excitatory postsynaptic potential	IEA	biological process
GO:0051209	release of sequestered calcium ion into cytosol	IEA	biological process
GO:0051209	release of sequestered calcium ion into cytosol	IEA	biological process
GO:0051219	phosphoprotein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction
hsa04750	Inflammatory mediator regulation of TRP channels

Diseases

Associated diseases	References
Adenomyosis	INFBASE: 20096818
Peritoneal endometriosis	INFBASE: 21160085
Sperm thermotaxis	MIK: 27992447
Male factor infertility	MIK: 23082196
Migraine	PMID:22162417
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq