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Gene id 7422
Gene Summary    Protein Summary    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol VEGFA   Gene   UCSC   Ensembl
Aliases MVCD1, VEGF, VPF
Gene name vascular endothelial growth factor A
Alternate names vascular endothelial growth factor A, vascular endothelial growth factor A121, vascular endothelial growth factor A165, vascular permeability factor,
Gene location 6p21.1 (43770208: 43786486)     Exons: 9     NC_000006.12
Gene summary(Entrez) This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for bot
OMIM 192240

Protein Summary

Protein general information P15692  

Name: Vascular endothelial growth factor A (VEGF A) (Vascular permeability factor) (VPF)

Length: 232  Mass: 27,042

Sequence MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKP
SCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKG
QKRKRKKSRYKSWSVYVGARCCLMPWSLPGPHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTC
RCDKPRR
Structural information
Interpro:  IPR029034  IPR023581  IPR000072  IPR027928  IPR036841  
Prosite:   PS00249 PS50278
CDD:   cd00135

PDB:  
1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS 4KZN 4QAF 4WPB 4ZFF 5DN2 5FV1 5FV2 5HHC 5HHD 5O4E 5T89
PDBsum:   1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS 4KZN 4QAF 4WPB 4ZFF 5DN2 5FV1 5FV2 5HHC 5HHD 5O4E 5T89

DIP:  

5740

MINT:  
STRING:   ENSP00000361125
Other Databases GeneCards:  VEGFA  Malacards:  VEGFA

KEGG pathways

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Pathway idPathway name
hsa04066HIF-1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04926Relaxin signaling pathway
hsa05200Pathways in cancer
hsa05206MicroRNAs in cancer
hsa05205Proteoglycans in cancer
hsa05212Pancreatic cancer
hsa05211Renal cell carcinoma
hsa05219Bladder cancer
hsa05323Rheumatoid arthritis
hsa05418Fluid shear stress and atherosclerosis
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05163Human cytomegalovirus infection
hsa05167Kaposi sarcoma-associated herpesvirus infection
hsa05165Human papillomavirus infection
hsa01521EGFR tyrosine kinase inhibitor resistance
Associated diseases References
Cancer (leiomyoma) GAD: 18256925
Cancer (leukemia) GAD: 20959405
Cancer (lung) GAD: 19170196
Cancer (lymphoma) GAD: 20029173
Cancer (mouth) GAD: 20303008
Cancer (myeloma) GAD: 20568250
Cancer (nasopharyngeal) GAD: 18588866
Cancer (oral) GAD: 15878754
Cancer (ovarian) GAD: 17289129
Cancer (prostate) GAD: 20096741
Cancer (Renal cell) GAD: 19551141
Cancer (Squamous cell) GAD: 20618614
Cancer (stomach) GAD: 17111394
Cancer (gastric) KEGG: H00018
Cancer GAD: 17287073
Cancer (Adenocarcinoma) GAD: 18414651
Cancer (Biliary tract neoplasms) GAD: 18676870
Cancer (bladder) GAD: 15667866
Cancer (cervical) GAD: 17630849
Cancer (colon) GAD: 17695550
Cancer (colorectal) GAD: 15522212
Cancer (endometrial) GAD: 18714564
Cancer (epithelial ovarian) GAD: 19064572
Cancer (esophageal) GAD: 19584152
Cancer (glioma) GAD: 20209496
Cancer (head and neck) GAD: 18164965
Cancer (Hepatocellular) GAD: 20082870
Cancer (kidney) GAD: 17287073
Cancer (breast) GAD: 12845639
Angina pectoris GAD: 18035072
Apoplexy GAD: 17702963
Atherosclerosis GAD: 19948975
Cardiovascular disease GAD: 20621071
Coronary heart disease GAD: 20364398
Hypertension GAD: 20621078
Congenital abnormalities GAD: 20140301
Bronchopulmonary dysplasia GAD: 18614962
Hyperparathyroidism GAD: 20424473
Macular degeneration GAD: 16940309
Retinopathy GAD: 15635051
Eye diseases GAD: 18554246
Sarcoidosis GAD: 12740269
Mucocutaneous lymph node syndrome GAD: 17874221
Henoch-Schonlein purpura GAD: 16395752
Hodgkin disease GAD: 19573080
Kawasaki disease GAD: 15470196
Ankylosing spondylitis GAD: 16014410
Arthritis GAD: 21089442
Asthma GAD: 16961715
Behcet's disease GAD: 15338501
Ulcerative colitis GAD: 21297633
Inflammatory bowel disease GAD: 16954806
Rheumatoid arthritis GAD: 15213335
Multiple sclerosis GAD: 18563468
Psoriasis GAD: 14962110
Psoriatic arthritis GAD: 17204151
Systemic lupus erythematosus (SLE) GAD: 21138680
Albuminuria GAD: 18363167
Diabetes GAD: 11978667
Hypercholesterolemia GAD: 20602615
Insulin resistance GAD: 20477880
Obesity GAD: 19884647
Metabolic syndrome GAD: 19056482
Osteoarthritis GAD: 18597093
Osteoporosis GAD: 19394248
Bone diseases GAD: 19453261
Giant cell arteritis GAD: 16142870
Alzheimer's disease GAD: 16569480
Amyotrophic lateral sclerosis (ALS) GAD: 16301496
Basal ganglia diseases GAD: 20413880
Autism GAD: 19598235
Dementia GAD: 16583410
Psychological disorders GAD: 16583410
Chronic renal failure GAD: 20383146
Kidney diseases GAD: 12597245
Abortion GAD: 20587610
Chorioamnionitis GAD: 20452482
HELLP Syndrome GAD: 18167313
Recurrent pregnancy loss (RPL) GAD: 15820807
Recurrent pregnancy loss (RPL) GAD: 19131057
Preterm birth risk GAD: 15059159
Adenomyosis INFBASE: 19197986
Angiogenesis INFBASE: 14724102
Recurrent implantation failure (RIF) INFBASE: 26305668
Fertilizing defects INFBASE: 24778347
Ectopic pregnancy INFBASE: 15251976
Embryo implantation INFBASE: 22028446
Endometrial polyp INFBASE: 24471989
Endometrial receptivity INFBASE: 19542542
Endometriosis INFBASE: 14724102
Endometriosis-associated infertility INFBASE: 20864099
Female infertility INFBASE: 15588162
Female subfertility INFBASE: 25243322
Follicular growth and development INFBASE: 21071025
Hydrosalpinx INFBASE: 14585871
Endometriosis INFBASE: 18706208
External gential endometriosis INFBASE: 16027877
Extrapelvic endometriosis INFBASE: 11605057
Preeclampsia INFBASE: 19474289
Polycystic ovary syndrome (PCOS) INFBASE: 14724102
Oocyte maturation INFBASE: 11438326
Polycystic ovary syndrome (PCOS) INFBASE: 23961784
Ovarian endometriosis INFBASE: 18053993
Pregnancy outcome INFBASE: 21315342
Polycystic ovary syndrome (PCOS) INFBASE: 26387454
Ovarian hyperstimulation syndrome (OHSS) INFBASE: 10783347
Premature ovarian failure (POF) INFBASE: 21831507
Unexplained infertility INFBASE: 18607827
Deep infiltrating endometriosis INFBASE: 17765237
Asthenozoospermia MIK: 17341438
Male factor infertility MIK: 10438994
Oligozoospermia MIK: 17341438
Endometriosis INFBASE: 26059828
Female infertility INFBASE: 24927079
Female infertility INFBASE: 25301487
Chronic obstructive pulmonary disease (COPD) GAD: 12853540
Pulmonary fibrosis GAD: 18256065
Connective tissue diseases GAD: 19527514
Atrophy GAD: 18079689
Respiratory distress syndrome GAD: 17289863
Avascular necrosis of femoral head KEGG: H01529
Glucocorticoid-induced osteonecrosis KEGG: H01709
Nephritis GAD: 19558800
Renal disease GAD: 16421229
Nephropathy GAD: 16526314
Spermatogenic defects MIK: 19593986
Associated with sperm maturation in the epididymus MIK: 15133891
Male infertility MIK: 15016771
Oligozoospermia MIK: 17341438
Asthenozoospermia MIK: 17341438

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
15588162 Infertilit
y

17
Male infertility
Show abstract
15016771 Male infer
tility

20 women underg
oing IVF treatm
ent because of
male infertilit
y
Male infertility
Show abstract
10438994 Male infer
tility

80 men whose sp
ermatozoa were
subsequently us
ed for IVF or I
CSI
Male infertility
Show abstract
17341438 Oligozoosp
ermia, ast
henozoospe
rmia

62 (34 controls
, 28 men with o
ligozoospermia
or asthenozoosp
ermia)
Male infertility IL-6
IL-8
VEGF
TNFalpha
IL-1beta
TGFbeta1 and G-CSF
Show abstract
10438994 Male infer
tility

80 men whose sp
ermatozoa were
subsequently us
ed for IVF or I
CSI
Male infertility Flt-1
 KDR
VEGF
Show abstract
19593986 Affect spe
rmatogenes
is and spe
rmiotelcos
is, which
may be one
of the ca
uses of va
ricocele-i
nduced mal
e infertil
ity or sub
fertility


Male infertility
Show abstract
15133891 Associated
with sper
m maturati
on in the
epididymus


Male infertility
Show abstract