• Gene id: 7372

Gene Summary

• Gene Symbol: UMPS   Gene   UCSC   Ensembl
• Aliases: OPRT
• Gene name: uridine monophosphate synthetase
• Alternate names: uridine 5'-monophosphate synthase, OMPdecase, OPRTase, UMP synthase, orotate phosphoribosyltransferase, orotidine 5'-phosphate decarboxylase,
• Gene location: 3q21.2 (124730365: 124749272)     Exons: 7     NC_000003.12
• Gene summary(Entrez): This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosp
• OMIM: 601934

Protein Summary

• Protein general information: P11172  
  • Name: Uridine 5' monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5' phosphate decarboxylase (ODC) (EC 4.1.1.23) (OMPdecase)]
  • Length: 480  
  • Mass: 52222
• Sequence:

  MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDTVCGVP
  YTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGSSVLETVEVLQKEGLKVTDAI
  VLLDREQGGKDKLQAHGIRLHSVCTLSKMLEILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKEL
  SFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT
  LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTG
  SLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVG
  RGIISAADRLEAAEMYRKAAWEAYLSRLGV

• Structural information:
  • Interpro: IPR013785  IPR014732  IPR018089  IPR001754  IPR023031   IPR004467  IPR000836  IPR029057  IPR011060  
  • Prosite: PS00156 PS00103
  • CDD: cd06223
  • PDB: 2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ 3EX1 3EX2 3EX3 3EX4 3EX6 3G3D 3G3M 3L0K 3L0N 3MI2 3MO7 3MW7 4HIB 4HKP
  • PDBsum: 2EAW 2JGY 2P1F 2QCC 2QCD 2QCE 2QCF 2QCG 2QCH 2QCL 2QCM 2QCN 2V30 2WNS 3BGG 3BGJ 3BK0 3BVJ 3DBP 3EWU 3EWW 3EWX 3EWY 3EWZ 3EX1 3EX2 3EX3 3EX4 3EX6 3G3D 3G3M 3L0K 3L0N 3MI2 3MO7 3MW7 4HIB 4HKP
  • DIP: 29595
  • STRING: ENSP00000232607
• Other Databases: GeneCards:  UMPS  Malacards:  UMPS

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0019856	pyrimidine nucleobase biosynthetic process	IBA	biological process
GO:0006222	UMP biosynthetic process	IBA	biological process
GO:0004590	orotidine-5'-phosphate decarboxylase activity	IBA	molecular function
GO:0004588	orotate phosphoribosyltransferase activity	IBA	molecular function
GO:0004588	orotate phosphoribosyltransferase activity	IEA	molecular function
GO:0004590	orotidine-5'-phosphate decarboxylase activity	IEA	molecular function
GO:0009116	nucleoside metabolic process	IEA	biological process
GO:0044205	'de novo' UMP biosynthetic process	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	IEA	biological process
GO:0006221	pyrimidine nucleotide biosynthetic process	IEA	biological process
GO:0016831	carboxy-lyase activity	IEA	molecular function
GO:0008152	metabolic process	IEA	biological process
GO:0016829	lyase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016757	transferase activity, transferring glycosyl groups	IEA	molecular function
GO:0006221	pyrimidine nucleotide biosynthetic process	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0004590	orotidine-5'-phosphate decarboxylase activity	IEA	molecular function
GO:0004588	orotate phosphoribosyltransferase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0046134	pyrimidine nucleoside biosynthetic process	TAS	biological process
GO:0035690	cellular response to drug	IEA	biological process
GO:0007595	lactation	IEA	biological process
GO:0007565	female pregnancy	IEA	biological process
GO:0006222	UMP biosynthetic process	IEA	biological process
GO:0004590	orotidine-5'-phosphate decarboxylase activity	IEA	molecular function
GO:0004588	orotate phosphoribosyltransferase activity	IEA	molecular function
GO:0044205	'de novo' UMP biosynthetic process	IEA	biological process
GO:0006222	UMP biosynthetic process	IDA	biological process
GO:0004590	orotidine-5'-phosphate decarboxylase activity	IDA	molecular function
GO:0004588	orotate phosphoribosyltransferase activity	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0006222	UMP biosynthetic process	IDA	biological process
GO:0004590	orotidine-5'-phosphate decarboxylase activity	IDA	molecular function
GO:0004588	orotate phosphoribosyltransferase activity	IDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00983	Drug metabolism - other enzymes
hsa00240	Pyrimidine metabolism

Diseases

Associated diseases	References
Orotic aciduria	KEGG:H00198
Orotic aciduria	KEGG:H00198
Purine-pyrimidine metabolic disorder	PMID:9042911
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881