• Gene id: 7332

Gene Summary

• Gene Symbol: UBE2L3   Gene   UCSC   Ensembl
• Aliases: E2-F1, L-UBC, UBCH7, UbcM4
• Gene name: ubiquitin conjugating enzyme E2 L3
• Alternate names: ubiquitin-conjugating enzyme E2 L3, E2 ubiquitin-conjugating enzyme L3, ubiquitin carrier protein L3, ubiquitin conjugating enzyme E2L 3, ubiquitin-conjugating enzyme E2-F1, ubiquitin-conjugating enzyme UBCH7, ubiquitin-protein ligase L3,
• Gene location: 22q11.21 (21549446: 21624033)     Exons: 4     NC_000022.11
• Gene summary(Entrez): The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjuga
• OMIM: 603721

Protein Summary

• Protein general information: P68036  
  • Name: Ubiquitin conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin conjugating enzyme L3) (L UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin conjugating enzyme E2 F1) (Ubiquitin protein ligase L3)
  • Length: 154  
  • Mass: 17862
  • Tissue specificity: Ubiquitous, with highest expression in testis.
• Sequence:

  MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAEYPFKPPKITFKTKIY
  HPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTKKYGEK
  RPVD

• Structural information:
  • Interpro: IPR000608  IPR023313  IPR016135  
  • Prosite: PS00183 PS50127
  • CDD: cd00195
  • PDB: 1C4Z 1FBV 3SQV 3SY2 4Q5E 4Q5H 5HPT 5TTE 5UDH 6CP2 6DJW 6DJX 6N13
  • PDBsum: 1C4Z 1FBV 3SQV 3SY2 4Q5E 4Q5H 5HPT 5TTE 5UDH 6CP2 6DJW 6DJX 6N13
  • DIP: 6124
  • STRING: ENSP00000485133
• Other Databases: GeneCards:  UBE2L3  Malacards:  UBE2L3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016740	transferase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0061631	ubiquitin conjugating enzyme activity	IEA	molecular function
GO:0061631	ubiquitin conjugating enzyme activity	IDA	molecular function
GO:0016567	protein ubiquitination	TAS	biological process
GO:0016567	protein ubiquitination	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0016567	protein ubiquitination	IDA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:1903508	positive regulation of nucleic acid-templated transcription	IEA	biological process
GO:0016567	protein ubiquitination	IEA	biological process
GO:0070979	protein K11-linked ubiquitination	IDA	biological process
GO:0004842	ubiquitin-protein transferase activity	IDA	molecular function
GO:0044770	cell cycle phase transition	IMP	biological process
GO:0019899	enzyme binding	TAS	molecular function
GO:0006511	ubiquitin-dependent protein catabolic process	TAS	biological process
GO:0006464	cellular protein modification process	TAS	biological process
GO:0004842	ubiquitin-protein transferase activity	TAS	molecular function
GO:0000151	ubiquitin ligase complex	TAS	cellular component
GO:0006511	ubiquitin-dependent protein catabolic process	TAS	biological process
GO:0004842	ubiquitin-protein transferase activity	TAS	molecular function
GO:0003723	RNA binding	HDA	molecular function
GO:0097027	ubiquitin-protein transferase activator activity	IGI	molecular function
GO:0031625	ubiquitin protein ligase binding	IPI	molecular function
GO:1903955	positive regulation of protein targeting to mitochondrion	HMP	biological process
GO:0051443	positive regulation of ubiquitin-protein transferase activity	IGI	biological process
GO:0031398	positive regulation of protein ubiquitination	IGI	biological process
GO:0070979	protein K11-linked ubiquitination	IBA	biological process
GO:0031625	ubiquitin protein ligase binding	IBA	molecular function
GO:0006511	ubiquitin-dependent protein catabolic process	IBA	biological process
GO:0000151	ubiquitin ligase complex	IBA	cellular component
GO:0061631	ubiquitin conjugating enzyme activity	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0000209	protein polyubiquitination	IBA	biological process
GO:0004842	ubiquitin-protein transferase activity	IDA	molecular function
GO:0004842	ubiquitin-protein transferase activity	IDA	molecular function
GO:0071385	cellular response to glucocorticoid stimulus	IDA	biological process
GO:0016567	protein ubiquitination	IDA	biological process
GO:0006355	regulation of transcription, DNA-templated	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0003713	transcription coactivator activity	IDA	molecular function
GO:0000209	protein polyubiquitination	IDA	biological process
GO:0000209	protein polyubiquitination	IDA	biological process
GO:0031625	ubiquitin protein ligase binding	IPI	molecular function
GO:0031625	ubiquitin protein ligase binding	IPI	molecular function
GO:0031625	ubiquitin protein ligase binding	IPI	molecular function
GO:0004842	ubiquitin-protein transferase activity	IMP	molecular function
GO:0071383	cellular response to steroid hormone stimulus	IMP	biological process
GO:0008283	cell population proliferation	IMP	biological process
GO:0006355	regulation of transcription, DNA-templated	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05012	Parkinson disease
hsa04120	Ubiquitin mediated proteolysis

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881