• Gene id: 7327

Gene Summary

• Gene Symbol: UBE2G2   Gene   UCSC   Ensembl
• Aliases: UBC7
• Gene name: ubiquitin conjugating enzyme E2 G2
• Alternate names: ubiquitin-conjugating enzyme E2 G2, E2 ubiquitin-conjugating enzyme G2, ubiquitin carrier protein G2, ubiquitin conjugating enzyme 7, ubiquitin conjugating enzyme G2, ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast), ubiquitin-conjugating enzyme E2G 2 (,
• Gene location: 21q22.3 (44801819: 44768579)     Exons: 8     NC_000002.12
• Gene summary(Entrez): The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conju
• OMIM: 603124

Protein Summary

Gene ontology

GO accession	Term name	Evidence code	Go category

KEGG pathways

Pathway id	Pathway name
hsa05012	Parkinson disease
hsa04141	Protein processing in endoplasmic reticulum
hsa05012	Parkinson disease
hsa04120	Ubiquitin mediated proteolysis

Diseases

Associated diseases	References
Male subfertility	MIK: 29230837
Male subfertility	MIK: 29230837
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
29230837	Male subfertility	Methylation patterns (cg07227024, cg05813498 and cg23081194)		136 (64 proven fertile males "controls" and 72 subfertile males "cases")	Male infertility	GAA UBE2G2 FLACC1
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R