• Gene id: 7326

Gene Summary

• Gene Symbol: UBE2G1   Gene   UCSC   Ensembl
• Aliases: E217K, UBC7, UBE2G
• Gene name: ubiquitin conjugating enzyme E2 G1
• Alternate names: ubiquitin-conjugating enzyme E2 G1, E2 ubiquitin-conjugating enzyme G1, ubiquitin carrier protein G1, ubiquitin conjugating enzyme E2G 1, ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans), ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast), ub,
• Gene location: 17p13.2 (39019080: 39055971)     Exons: 9     NC_000022.11
• Gene summary(Entrez): The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conju
• OMIM: 601569

Protein Summary

• Protein general information: P62253  
  • Name: Ubiquitin conjugating enzyme E2 G1 (EC 2.3.2.23) (E2 ubiquitin conjugating enzyme G1) (E217K) (UBC7) (Ubiquitin carrier protein G1) (Ubiquitin protein ligase G1) [Cleaved into: Ubiquitin conjugating enzyme E2 G1, N terminally processed]
  • Length: 170  
  • Mass: 19509
  • Tissue specificity: Widely expressed, mainly in skeletal muscle. {ECO
• Sequence:

  MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLTFPKDYPLRPPKMKFI
  TEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTVETIMISVISMLADPNGDSPANVDAAKEWREDRN
  GEFKRKVARCVRKSQETAFE

• Structural information:
  • Interpro: IPR000608  IPR023313  IPR016135  
  • Prosite: PS00183 PS50127
  • CDD: cd00195
  • PDB: 2AWF 6D68
  • PDBsum: 2AWF 6D68
  • STRING: ENSP00000380178
• Other Databases: GeneCards:  UBE2G1  Malacards:  UBE2G1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0061631	ubiquitin conjugating enzyme activity	IDA	molecular function
GO:0031625	ubiquitin protein ligase binding	IPI	molecular function
GO:0070936	protein K48-linked ubiquitination	IDA	biological process
GO:0000209	protein polyubiquitination	IBA	biological process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	biological process
GO:0061631	ubiquitin conjugating enzyme activity	IBA	molecular function
GO:0006511	ubiquitin-dependent protein catabolic process	IBA	biological process
GO:0031625	ubiquitin protein ligase binding	IPI	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0006511	ubiquitin-dependent protein catabolic process	TAS	biological process
GO:0061631	ubiquitin conjugating enzyme activity	IEA	molecular function
GO:0061631	ubiquitin conjugating enzyme activity	IDA	molecular function
GO:0044257	cellular protein catabolic process	IMP	biological process
GO:0016567	protein ubiquitination	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0070936	protein K48-linked ubiquitination	IEA	biological process
GO:0004842	ubiquitin-protein transferase activity	IEA	molecular function
GO:0016567	protein ubiquitination	IEA	biological process
GO:0070534	protein K63-linked ubiquitination	IDA	biological process
GO:0004842	ubiquitin-protein transferase activity	IDA	molecular function
GO:0070936	protein K48-linked ubiquitination	IDA	biological process
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa05012	Parkinson disease
hsa04141	Protein processing in endoplasmic reticulum
hsa04120	Ubiquitin mediated proteolysis

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray