• Gene id: 7322

Gene Summary

• Gene Symbol: UBE2D2   Gene   UCSC   Ensembl
• Aliases: E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B
• Gene name: ubiquitin conjugating enzyme E2 D2
• Alternate names: ubiquitin-conjugating enzyme E2 D2, (E3-independent) E2 ubiquitin-conjugating enzyme D2, E2 ubiquitin-conjugating enzyme D2, p53-regulated ubiquitin-conjugating enzyme 1, ubiquitin carrier protein D2, ubiquitin conjugating enzyme E2D 2, ubiquitin-conjugating en,
• Gene location: 5q31.2 (139561165: 139628433)     Exons: 10     NC_000012.12
• Gene summary(Entrez): Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing prot
• OMIM: 602962

Protein Summary

Gene ontology

GO accession	Term name	Evidence code	Go category

KEGG pathways

Pathway id	Pathway name
hsa05131	Shigellosis
hsa04141	Protein processing in endoplasmic reticulum
hsa04120	Ubiquitin mediated proteolysis
hsa05131	Shigellosis

Diseases

Associated diseases	References
Plays a role in early maturation of the testis	MIK: 16024774
Cryptorchidism	MIK: 28606200
Plays a role in early maturation of the testis	MIK: 16024774
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
16024774	Plays a role in early maturation of the testis				Male infertility
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray