• Gene id: 7272

Gene Summary

• Gene Symbol: TTK   Gene   UCSC   Ensembl
• Aliases: CT96, ESK, MPH1, MPS1, MPS1L1, PYT
• Gene name: TTK protein kinase
• Alternate names: dual specificity protein kinase TTK, cancer/testis antigen 96, monopolar spindle 1 kinase, monopolar spindle 1-like 1, phosphotyrosine picked threonine kinase, phosphotyrosine picked threonine-protein kinase,
• Gene location: 6q14.1 (80004146: 80042650)     Exons: 23     NC_000006.12
• Gene summary(Entrez): This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required f
• OMIM: 604092

Protein Summary

• Protein general information: P33981  
  • Name: Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine protein kinase) (PYT)
  • Length: 857  
  • Mass: 97072
  • Tissue specificity: Present in rapidly proliferating cell lines.
• Sequence:

  MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMANNPEDWLSLLLKLEKN
  SVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFA
  QFELSQGNVKKSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNR
  NNSCDSRGQTTKARFLYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
  TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQ
  EPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSI
  CKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIY
  SILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
  VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDT
  TSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDP
  NHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSI
  LKAAKTLYEHYSGGESHNSSSSKTFEKKRGKK

• Structural information:
  • Protein Domains: (525..79-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR011009  IPR027084  IPR000719  IPR017441  IPR008271   IPR011990  
  • Prosite: PS00107 PS50011 PS00108
  • PDB: 2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 3WYX 3WYY 3WZJ 3WZK 4B94 4BHZ 4BI0 4BI1 4BI2 4C4E 4C4F 4C4G 4C4H 4C4I 4C4J 4CV8 4CV9 4CVA 4D2S 4H7X 4H7Y 4JS8 4JT3 4O6L 4ZEG 5AP0 5AP1 5AP2 5AP3 5AP4 5AP5 5AP6 5AP7 5EH0 5EHL 5EHO 5EHY 5EI2 5EI6 5EI8 5LJJ 5MRB 5N7V 5N84 5N87 5N93 5N9S 5NA0 5NAD 5NTT 5O91 6B4
  • PDBsum: 2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 3WYX 3WYY 3WZJ 3WZK 4B94 4BHZ 4BI0 4BI1 4BI2 4C4E 4C4F 4C4G 4C4H 4C4I 4C4J 4CV8 4CV9 4CVA 4D2S 4H7X 4H7Y 4JS8 4JT3 4O6L 4ZEG 5AP0 5AP1 5AP2 5AP3 5AP4 5AP5 5AP6 5AP7 5EH0 5EHL 5EHO 5EHY 5EI2 5EI6 5EI8 5LJJ 5MRB 5N7V 5N84 5N87 5N93 5N9S 5NA0 5NAD 5NTT 5O91 6B4
  • DIP: 40642
  • STRING: ENSP00000358813
• Other Databases: GeneCards:  TTK  Malacards:  TTK

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000776	kinetochore	IBA	cellular component
GO:0004712	protein serine/threonine/tyrosine kinase activity	IBA	molecular function
GO:0018105	peptidyl-serine phosphorylation	IBA	biological process
GO:0033316	meiotic spindle assembly checkpoint	IBA	biological process
GO:0034501	protein localization to kinetochore	IBA	biological process
GO:0004674	protein serine/threonine kinase activity	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0005819	spindle	IBA	cellular component
GO:0007059	chromosome segregation	IBA	biological process
GO:0007094	mitotic spindle assembly checkpoint	IBA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0004712	protein serine/threonine/tyrosine kinase activity	IEA	molecular function
GO:0007093	mitotic cell cycle checkpoint	IEA	biological process
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0051304	chromosome separation	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0004713	protein tyrosine kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0004713	protein tyrosine kinase activity	TAS	molecular function
GO:0004674	protein serine/threonine kinase activity	TAS	molecular function
GO:0005819	spindle	TAS	cellular component
GO:0007094	mitotic spindle assembly checkpoint	TAS	biological process
GO:0007051	spindle organization	TAS	biological process
GO:0007052	mitotic spindle organization	TAS	biological process
GO:0008284	positive regulation of cell population proliferation	TAS	biological process
GO:0004712	protein serine/threonine/tyrosine kinase activity	IEA	molecular function
GO:0046777	protein autophosphorylation	IEA	biological process
GO:0043515	kinetochore binding	IEA	molecular function
GO:0034501	protein localization to kinetochore	IEA	biological process
GO:0033316	meiotic spindle assembly checkpoint	IEA	biological process
GO:0018108	peptidyl-tyrosine phosphorylation	IEA	biological process
GO:0018105	peptidyl-serine phosphorylation	IEA	biological process
GO:0004712	protein serine/threonine/tyrosine kinase activity	IEA	molecular function
GO:0000776	kinetochore	IEA	cellular component
GO:1903096	protein localization to meiotic spindle midzone	IEA	biological process
GO:0034502	protein localization to chromosome	IEA	biological process
GO:0018107	peptidyl-threonine phosphorylation	IEA	biological process
GO:0016321	female meiosis chromosome segregation	IEA	biological process
GO:0007094	mitotic spindle assembly checkpoint	IEA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	TAS	biological process
GO:0016020	membrane	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04110	Cell cycle

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R