|
Gene id |
7180 |
| Gene Summary Protein Summary Gene ontology Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
CRISP2 Gene UCSC Ensembl |
|
Aliases |
CRISP-2, CT36, GAPDL5, TPX1, TSP1 |
|
Gene name |
cysteine rich secretory protein 2 |
|
Alternate names |
cysteine-rich secretory protein 2, cancer/testis antigen 36, glyceraldehyde-3-phosphate dehydrogenase-like 5, testicular tissue protein Li 43, testis specific protein 1 (probe H4-1 p3-1), testis-specific protein TPX-1, |
|
Gene location |
6p12.3 (49714197: 49676664) Exons: 14 NC_000006.12
|
|
OMIM |
187430 |
Protein Summary
|
| Protein general information
| P16562
Name: Cysteine rich secretory protein 2 (CRISP 2) (Cancer/testis antigen 36) (CT36) (Testis specific protein TPX 1)
Length: 243 Mass: 27,259
|
| Sequence |
MALLPVLFLVTVLLPSLPAEGKDPAFTALLTTQLQVQREIVNKHNELRKAVSPPASNMLKMEWSREVTTNAQRWA
NKCTLQHSDPEDRKTSTRCGENLYMSSDPTSWSSAIQSWYDEILDFVYGVGPKSPNAVVGHYTQLVWYSTYQVGC
GIAYCPNQDSLKYYYVCQYCPAGNNMNRKNTPYQQGTPCAGCPDDCDKGLCTNSCQYQDLLSNCDSLKNTAGCEH
ELLKEKCKATCLCENKIY
|
| Structural information |
|
| Other Databases |
GeneCards: CRISP2 Malacards: CRISP2 |
|
| GO accession | Term name | Evidence code | Go category |
|---|
| GO:0005615 |
extracellular space
|
TAS |
cellular component |
GO:0016337 |
single organismal cell-ce
ll adhesion
|
IEA |
biological process |
GO:0005576 |
extracellular region
|
IEA |
cellular component |
GO:0005576 |
extracellular region
|
IEA |
cellular component |
GO:0005576 |
extracellular region
|
IEA |
cellular component |
GO:0005615 |
extracellular space
|
TAS |
cellular component |
GO:0016337 |
single organismal cell-ce
ll adhesion
|
IEA |
biological process |
GO:0005615 |
extracellular space
|
TAS |
cellular component |
|
|
| Associated diseases |
References |
| Asthenozoospermia | MIK: 25345956 |
| Sperm motility | MIK: 21485539 |
| Male factor infertility | MIK: 18550510 |
| Varicocele | MIK: 25890347 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Asthenoteratozoospermia | MIK: 27517483 |
| Asthenozoospermia | MIK: 25345956 |
| Fertilizing defects | MIK: 26786179 |
| Male infertility | MIK: 18550510 |
| Non obstructive azoospermia | MIK: 24012201 |
| Sertoli cell only syndrome | MIK: 23869807 |
| Plays a role in acrosome development | MIK: 17377140 |
| Plays a role in attainment of sperm functional competence | MIK: 19686095 |
| Spermatogenic defects | MIK: 31037746 |
| Varicocele | MIK: 25890347 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 25890347 |
Varicocele
|
|
|
10 (5 unilatera
l varicocele, 5
fertile men)
|
Male infertility |
CRISP2
ARG2
|
Show abstract |
| 25505194 |
Asthenozoo
spermia, m
ale infert
ility
|
|
|
|
Male infertility |
|
Show abstract |
| 25345956 |
Asthenozoo
spermia
|
|
|
48 (24 normal v
olunteers, 24 p
atients with as
thenozoospermia
)
|
Male infertility |
|
Show abstract |
| 21485539 |
Asthenospe
rmia, sper
m motility
|
|
|
148 (78 semen s
amples from adu
lt male patient
s with asthenos
permia, another
70 from health
y volunteers as
controls)
|
Male infertility |
CRISP2
|
Show abstract |
| 18550510 |
Male infer
tility
|
C196R, L59V, M176I |
|
268 (92 inferti
le men with ast
henozoo- and/or
teratozoosperm
ia, 176 control
men)
|
Male infertility |
CRISP2
|
Show abstract |
| 19686095 |
Plays a ro
le in atta
inment of
sperm func
tional com
petence
|
|
|
|
Male infertility |
|
Show abstract |
| 17377140 |
Plays a ro
le in acro
some devel
opment
|
|
|
|
Male infertility |
|
Show abstract |
| 27517483 |
Asthenoter
atozoosper
mia, Male
infertilit
y
|
|
|
|
Male infertility |
|
Show abstract |
| 24012201 |
Non obstru
ctive azoo
spermia
|
|
|
31 (4 controls,
27 cases)
|
Male infertility |
GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 23869807 |
Non obstru
ctive azoo
spermia, S
ertoli cel
l only syn
drome
|
|
|
20 (4 controls,
16 cases)
|
Male infertility |
GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
16 (1 control,
15 cases)
|
Male infertility |
GSE6023 analyzed using GEO2R
|
Show abstract |
| 26786179 |
Fertilizin
g defects
|
|
|
|
Male infertility |
|
Show abstract |
|