Male Infertility Database

Search Result

Gene id

7124

Gene Summary SNPs Protein Summary Gene ontology KEGG pathways Diseases PubMed

Gene Summary

Gene Symbol

TNF Gene UCSC Ensembl

Aliases

DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F

Gene name

tumor necrosis factor

Alternate names

tumor necrosis factor, APC1 protein, TNF, macrophage-derived, TNF, monocyte-derived, TNF-a, cachectin, tumor necrosis factor ligand 1F, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha,

Gene location

6p21.33 (31575564: 31578335) Exons: 4 NC_000006.12

Gene summary(Entrez)

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B

OMIM

191160

SNPs

rs1800629

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000006.12   g.31575254G>A
NC_000006.11   g.31543031G>A
NG_007462.1   g.4682G>A
NG_012010.1   g.8156G>A
NT_113891.3   g.3052541A>G
NT_113891.2   g.3052647A>G
NT_167246.2   g.2880295G>A
NT_167246.1   g.2885915G>A
NT_167249.2   g.2874534G>A
NT_167249.1   g.2873832G>A
NT

rs1799964

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000006.12   g.31574531T>C
NC_000006.11   g.31542308T>C
NG_007462.1   g.3959T>C
NG_012010.1   g.7433T>C
NT_113891.3   g.3051818T>C
NT_113891.2   g.3051924T>C
NT_167246.2   g.2879572T>C
NT_167246.1   g.2885192T>C
NT_167249.2   g.2873811T>C
NT_167249.1   g.2873109T>C
NT

rs1799724

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000006.12   g.31574705C>T
NC_000006.11   g.31542482C>T
NG_007462.1   g.4133C>T
NG_012010.1   g.7607C>T
NT_113891.3   g.3051992C>T
NT_113891.2   g.3052098C>T
NT_167246.2   g.2879746C>T
NT_167246.1   g.2885366C>T
NT_167249.2   g.2873985C>T
NT_167249.1   g.2873283C>T
NT

rs1800750

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000006.12   g.31575186G>A
NC_000006.11   g.31542963G>A
NG_007462.1   g.4614G>A
NG_012010.1   g.8088G>A
NT_113891.3   g.3052473G>A
NT_113891.2   g.3052579G>A
NT_167246.2   g.2880227G>A
NT_167246.1   g.2885847G>A
NT_167249.2   g.2874466G>A
NT_167249.1   g.2873764G>A
NT

rs361525

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000006.12   g.31575324G>A
NC_000006.11   g.31543101G>A
NG_007462.1   g.4752G>A
NG_012010.1   g.8226G>A
NT_113891.3   g.3052611G>A
NT_113891.2   g.3052717G>A
NT_167246.2   g.2880365G>A
NT_167246.1   g.2885985G>A
NT_167249.2   g.2874604G>A
NT_167249.1   g.2873902G>A
NT

Protein Summary

Protein general information

P01375

Name: Tumor necrosis factor (Cachectin) (TNF alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF a) [Cleaved into: Tumor necrosis factor, membrane form (N terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C doma

Length: 233 Mass: 25644

Sequence

MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQ
AVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHV
LLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQ
VYFGIIAL

Structural information

Interpro:	IPR006053 IPR002959 IPR021184 IPR006052 IPR008983
Prosite:	PS00251 PS50049
CDD:	cd00184
PDB:	1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 4TWT 4Y6O 5M2I 5M2J 5M2M 5MU8 5TSW 5UUI 5WUX 5YOY 6OOY 6OOZ 6OP0 6RMJ
PDBsum:	1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 4TWT 4Y6O 5M2I 5M2J 5M2M 5MU8 5TSW 5UUI 5WUX 5YOY 6OOY 6OOZ 6OP0 6RMJ
DIP:	2895
MINT:
STRING:	ENSP00000398698

Other Databases

GeneCards: TNF Malacards: TNF

Gene ontology

Expand All | Collapse All

GO accession	Term name	Evidence code	Go category
GO:0000060	protein import into nucle us, translocation	IDA	biological process
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	IDA	biological process
GO:0000165	MAPK cascade	IMP	biological process
GO:0000185	activation of MAPKKK acti vity	IDA	biological process
GO:0000187	activation of MAPK activi ty	IDA	biological process
GO:0001819	positive regulation of cy tokine production	IDA	biological process
GO:0001891	phagocytic cup	ISS	cellular component
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological process
GO:0002020	protease binding	IPI	molecular function
GO:0002439	chronic inflammatory resp onse to antigenic stimulu s	IMP	biological process
GO:0002740	negative regulation of cy tokine secretion involved in immune response	IDA	biological process
GO:0002876	positive regulation of ch ronic inflammatory respon se to antigenic stimulus	IEA	biological process
GO:0002925	positive regulation of hu moral immune response med iated by circulating immu noglobulin	IEA	biological process
GO:0005125	cytokine activity	IDA	molecular function
GO:0005164	tumor necrosis factor rec eptor binding	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005887	integral component of pla sma membrane	IDA	cellular component
GO:0006006	glucose metabolic process	IEA	biological process
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IDA	biological process
GO:0006954	inflammatory response	IDA	biological process
GO:0006954	inflammatory response	IDA	biological process
GO:0006954	inflammatory response	IDA	biological process
GO:0006959	humoral immune response	IEA	biological process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	TAS	biological process
GO:0007254	JNK cascade	IEA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	NAS	biological process
GO:0008630	intrinsic apoptotic signa ling pathway in response to DNA damage	IEA	biological process
GO:0009615	response to virus	IDA	biological process
GO:0009651	response to salt stress	TAS	biological process
GO:0009897	external side of plasma m embrane	ISS	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0010628	positive regulation of ge ne expression	IMP	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IMP	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010629	negative regulation of ge ne expression	IDA	biological process
GO:0010629	negative regulation of ge ne expression	IDA	biological process
GO:0010693	negative regulation of al kaline phosphatase activi ty	IEA	biological process
GO:0010803	regulation of tumor necro sis factor-mediated signa ling pathway	TAS	biological process
GO:0010888	negative regulation of li pid storage	NAS	biological process
GO:0030198	extracellular matrix orga nization	IEA	biological process
GO:0030316	osteoclast differentiatio n	IEA	biological process
GO:0030730	sequestering of triglycer ide	IDA	biological process
GO:0030866	cortical actin cytoskelet on organization	IDA	biological process
GO:0031334	positive regulation of pr otein complex assembly	IDA	biological process
GO:0031622	positive regulation of fe ver generation	ISS	biological process
GO:0031663	lipopolysaccharide-mediat ed signaling pathway	IDA	biological process
GO:0032715	negative regulation of in terleukin-6 production	IDA	biological process
GO:0032722	positive regulation of ch emokine production	IDA	biological process
GO:0032729	positive regulation of in terferon-gamma production	IEA	biological process
GO:0032755	positive regulation of in terleukin-6 production	IEA	biological process
GO:0032757	positive regulation of in terleukin-8 production	IMP	biological process
GO:0032800	receptor biosynthetic pro cess	IDA	biological process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	IMP	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological process
GO:0035509	negative regulation of my osin-light-chain-phosphat ase activity	IDA	biological process
GO:0042346	positive regulation of NF -kappaB import into nucle us	IDA	biological process
GO:0042802	identical protein binding	IDA	molecular function
GO:0043065	positive regulation of ap optotic process	IDA	biological process
GO:0043065	positive regulation of ap optotic process	IDA	biological process
GO:0043065	positive regulation of ap optotic process	IDA	biological process
GO:0043065	positive regulation of ap optotic process	IMP	biological process
GO:0043068	positive regulation of pr ogrammed cell death	IDA	biological process
GO:0043122	regulation of I-kappaB ki nase/NF-kappaB signaling	IDA	biological process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological process
GO:0043242	negative regulation of pr otein complex disassembly	IDA	biological process
GO:0043243	positive regulation of pr otein complex disassembly	IDA	biological process
GO:0043243	positive regulation of pr otein complex disassembly	IDA	biological process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological process
GO:0043491	protein kinase B signalin g	IMP	biological process
GO:0043507	positive regulation of JU N kinase activity	IDA	biological process
GO:0044130	negative regulation of gr owth of symbiont in host	IEA	biological process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular function
GO:0045071	negative regulation of vi ral genome replication	IDA	biological process
GO:0045080	positive regulation of ch emokine biosynthetic proc ess	IDA	biological process
GO:0045121	membrane raft	IDA	cellular component
GO:0045416	positive regulation of in terleukin-8 biosynthetic process	IDA	biological process
GO:0045429	positive regulation of ni tric oxide biosynthetic p rocess	IDA	biological process
GO:0045599	negative regulation of fa t cell differentiation	NAS	biological process
GO:0045662	negative regulation of my oblast differentiation	IEA	biological process
GO:0045668	negative regulation of os teoblast differentiation	IEA	biological process
GO:0045672	positive regulation of os teoclast differentiation	IDA	biological process
GO:0045785	positive regulation of ce ll adhesion	IMP	biological process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IGI	biological process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological process
GO:0045994	positive regulation of tr anslational initiation by iron	IEA	biological process
GO:0046325	negative regulation of gl ucose import	IEA	biological process
GO:0048566	embryonic digestive tract development	IEP	biological process
GO:0048661	positive regulation of sm ooth muscle cell prolifer ation	IDA	biological process
GO:0050715	positive regulation of cy tokine secretion	IDA	biological process
GO:0050766	positive regulation of ph agocytosis	IMP	biological process
GO:0050796	regulation of insulin sec retion	IDA	biological process
GO:0050830	defense response to Gram- positive bacterium	IEA	biological process
GO:0050901	leukocyte tethering or ro lling	IDA	biological process
GO:0050995	negative regulation of li pid catabolic process	IDA	biological process
GO:0051023	regulation of immunoglobu lin secretion	IEA	biological process
GO:0051044	positive regulation of me mbrane protein ectodomain proteolysis	IDA	biological process
GO:0051091	positive regulation of se quence-specific DNA bindi ng transcription factor a ctivity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IMP	biological process
GO:0051222	positive regulation of pr otein transport	IDA	biological process
GO:0051384	response to glucocorticoi d	IDA	biological process
GO:0051533	positive regulation of NF AT protein import into nu cleus	IDA	biological process
GO:0051798	positive regulation of ha ir follicle development	IEA	biological process
GO:0051897	positive regulation of pr otein kinase B signaling	IEA	biological process
GO:0055037	recycling endosome	ISS	cellular component
GO:0060557	positive regulation of vi tamin D biosynthetic proc ess	IDA	biological process
GO:0060559	positive regulation of ca lcidiol 1-monooxygenase a ctivity	IDA	biological process
GO:0060664	epithelial cell prolifera tion involved in salivary gland morphogenesis	IEA	biological process
GO:0060693	regulation of branching i nvolved in salivary gland morphogenesis	IEA	biological process
GO:0061048	negative regulation of br anching involved in lung morphogenesis	IDA	biological process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	NAS	biological process
GO:0071230	cellular response to amin o acid stimulus	IEA	biological process
GO:0071316	cellular response to nico tine	IDA	biological process
GO:0071407	cellular response to orga nic cyclic compound	IDA	biological process
GO:0071550	death-inducing signaling complex assembly	TAS	biological process
GO:0071677	positive regulation of mo nonuclear cell migration	NAS	biological process
GO:0071803	positive regulation of po dosome assembly	IDA	biological process
GO:0090002	establishment of protein localization to plasma me mbrane	IDA	biological process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:1901224	positive regulation of NI K/NF-kappaB signaling	IDA	biological process
GO:1901671	positive regulation of su peroxide dismutase activi ty	IDA	biological process
GO:1903140	regulation of establishme nt of endothelial barrier	IDA	biological process
GO:1903347	negative regulation of bi cellular tight junction a ssembly	IDA	biological process
GO:1904999	positive regulation of le ukocyte adhesion to arter ial endothelial cell	IDA	biological process
GO:2000010	positive regulation of pr otein localization to cel l surface	IDA	biological process
GO:2000304	positive regulation of ce ramide biosynthetic proce ss	TAS	biological process
GO:2000334	positive regulation of bl ood microparticle formati on	IDA	biological process
GO:2000343	positive regulation of ch emokine (C-X-C motif) lig and 2 production	IDA	biological process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological process
GO:0000060	protein import into nucle us, translocation	IDA	biological process
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	IEA	biological process
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	IDA	biological process
GO:0000165	MAPK cascade	IMP	biological process
GO:0000185	activation of MAPKKK acti vity	IDA	biological process
GO:0000187	activation of MAPK activi ty	IDA	biological process
GO:0001819	positive regulation of cy tokine production	IDA	biological process
GO:0001891	phagocytic cup	IEA	cellular component
GO:0001891	phagocytic cup	ISS	cellular component
GO:0001932	regulation of protein pho sphorylation	IEA	biological process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological process
GO:0002020	protease binding	IEA	molecular function
GO:0002020	protease binding	IPI	molecular function
GO:0002439	chronic inflammatory resp onse to antigenic stimulu s	IMP	biological process
GO:0002740	negative regulation of cy tokine secretion involved in immune response	IDA	biological process
GO:0002876	positive regulation of ch ronic inflammatory respon se to antigenic stimulus	IEA	biological process
GO:0002925	positive regulation of hu moral immune response med iated by circulating immu noglobulin	IEA	biological process
GO:0005125	cytokine activity	IEA	molecular function
GO:0005125	cytokine activity	IEA	molecular function
GO:0005125	cytokine activity	IDA	molecular function
GO:0005164	tumor necrosis factor rec eptor binding	IEA	molecular function
GO:0005164	tumor necrosis factor rec eptor binding	IEA	molecular function
GO:0005164	tumor necrosis factor rec eptor binding	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005622	intracellular	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005887	integral component of pla sma membrane	IDA	cellular component
GO:0006006	glucose metabolic process	IEA	biological process
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IEA	biological process
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IDA	biological process
GO:0006952	defense response	IEA	biological process
GO:0006954	inflammatory response	IEA	biological process
GO:0006954	inflammatory response	IDA	biological process
GO:0006954	inflammatory response	IDA	biological process
GO:0006954	inflammatory response	IDA	biological process
GO:0006955	immune response	IEA	biological process
GO:0006959	humoral immune response	IEA	biological process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	TAS	biological process
GO:0007254	JNK cascade	IEA	biological process
GO:0007275	multicellular organism de velopment	IEA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IEA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	NAS	biological process
GO:0008630	intrinsic apoptotic signa ling pathway in response to DNA damage	IEA	biological process
GO:0009615	response to virus	IDA	biological process
GO:0009651	response to salt stress	TAS	biological process
GO:0009887	animal organ morphogenesi s	IEA	biological process
GO:0009897	external side of plasma m embrane	IEA	cellular component
GO:0009897	external side of plasma m embrane	ISS	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0010033	response to organic subst ance	IEA	biological process
GO:0010628	positive regulation of ge ne expression	IMP	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IMP	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010629	negative regulation of ge ne expression	IDA	biological process
GO:0010629	negative regulation of ge ne expression	IDA	biological process
GO:0010693	negative regulation of al kaline phosphatase activi ty	IEA	biological process
GO:0010803	regulation of tumor necro sis factor-mediated signa ling pathway	TAS	biological process
GO:0010888	negative regulation of li pid storage	NAS	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of mem brane	IEA	cellular component
GO:0030198	extracellular matrix orga nization	IEA	biological process
GO:0030316	osteoclast differentiatio n	IEA	biological process
GO:0030730	sequestering of triglycer ide	IDA	biological process
GO:0030866	cortical actin cytoskelet on organization	IDA	biological process
GO:0031334	positive regulation of pr otein complex assembly	IDA	biological process
GO:0031622	positive regulation of fe ver generation	IEA	biological process
GO:0031622	positive regulation of fe ver generation	ISS	biological process
GO:0031663	lipopolysaccharide-mediat ed signaling pathway	IDA	biological process
GO:0032715	negative regulation of in terleukin-6 production	IDA	biological process
GO:0032722	positive regulation of ch emokine production	IDA	biological process
GO:0032729	positive regulation of in terferon-gamma production	IEA	biological process
GO:0032755	positive regulation of in terleukin-6 production	IEA	biological process
GO:0032757	positive regulation of in terleukin-8 production	IMP	biological process
GO:0032800	receptor biosynthetic pro cess	IDA	biological process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	IEA	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	IMP	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological process
GO:0035509	negative regulation of my osin-light-chain-phosphat ase activity	IDA	biological process
GO:0042127	regulation of cell prolif eration	IEA	biological process
GO:0042346	positive regulation of NF -kappaB import into nucle us	IEA	biological process
GO:0042346	positive regulation of NF -kappaB import into nucle us	IDA	biological process
GO:0042742	defense response to bacte rium	IEA	biological process
GO:0042802	identical protein binding	IDA	molecular function
GO:0043065	positive regulation of ap optotic process	IDA	biological process
GO:0043065	positive regulation of ap optotic process	IDA	biological process
GO:0043065	positive regulation of ap optotic process	IDA	biological process
GO:0043065	positive regulation of ap optotic process	IMP	biological process
GO:0043068	positive regulation of pr ogrammed cell death	IDA	biological process
GO:0043122	regulation of I-kappaB ki nase/NF-kappaB signaling	IDA	biological process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IEA	biological process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological process
GO:0043242	negative regulation of pr otein complex disassembly	IDA	biological process
GO:0043243	positive regulation of pr otein complex disassembly	IDA	biological process
GO:0043243	positive regulation of pr otein complex disassembly	IDA	biological process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological process
GO:0043491	protein kinase B signalin g	IMP	biological process
GO:0043507	positive regulation of JU N kinase activity	IDA	biological process
GO:0044130	negative regulation of gr owth of symbiont in host	IEA	biological process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular function
GO:0045071	negative regulation of vi ral genome replication	IDA	biological process
GO:0045080	positive regulation of ch emokine biosynthetic proc ess	IDA	biological process
GO:0045121	membrane raft	IEA	cellular component
GO:0045121	membrane raft	IDA	cellular component
GO:0045123	cellular extravasation	IEA	biological process
GO:0045416	positive regulation of in terleukin-8 biosynthetic process	IDA	biological process
GO:0045429	positive regulation of ni tric oxide biosynthetic p rocess	IDA	biological process
GO:0045599	negative regulation of fa t cell differentiation	NAS	biological process
GO:0045662	negative regulation of my oblast differentiation	IEA	biological process
GO:0045668	negative regulation of os teoblast differentiation	IEA	biological process
GO:0045670	regulation of osteoclast differentiation	IEA	biological process
GO:0045672	positive regulation of os teoclast differentiation	IDA	biological process
GO:0045785	positive regulation of ce ll adhesion	IMP	biological process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IEA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IEA	biological process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IGI	biological process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological process
GO:0045994	positive regulation of tr anslational initiation by iron	IEA	biological process
GO:0046325	negative regulation of gl ucose import	IEA	biological process
GO:0046330	positive regulation of JN K cascade	IEA	biological process
GO:0048566	embryonic digestive tract development	IEP	biological process
GO:0048661	positive regulation of sm ooth muscle cell prolifer ation	IDA	biological process
GO:0050708	regulation of protein sec retion	IEA	biological process
GO:0050715	positive regulation of cy tokine secretion	IDA	biological process
GO:0050766	positive regulation of ph agocytosis	IMP	biological process
GO:0050796	regulation of insulin sec retion	IDA	biological process
GO:0050830	defense response to Gram- positive bacterium	IEA	biological process
GO:0050900	leukocyte migration	IEA	biological process
GO:0050901	leukocyte tethering or ro lling	IDA	biological process
GO:0050995	negative regulation of li pid catabolic process	IDA	biological process
GO:0051023	regulation of immunoglobu lin secretion	IEA	biological process
GO:0051044	positive regulation of me mbrane protein ectodomain proteolysis	IDA	biological process
GO:0051091	positive regulation of se quence-specific DNA bindi ng transcription factor a ctivity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IMP	biological process
GO:0051222	positive regulation of pr otein transport	IDA	biological process
GO:0051384	response to glucocorticoi d	IDA	biological process
GO:0051533	positive regulation of NF AT protein import into nu cleus	IDA	biological process
GO:0051798	positive regulation of ha ir follicle development	IEA	biological process
GO:0051897	positive regulation of pr otein kinase B signaling	IEA	biological process
GO:0055037	recycling endosome	IEA	cellular component
GO:0055037	recycling endosome	ISS	cellular component
GO:0060557	positive regulation of vi tamin D biosynthetic proc ess	IDA	biological process
GO:0060559	positive regulation of ca lcidiol 1-monooxygenase a ctivity	IDA	biological process
GO:0060664	epithelial cell prolifera tion involved in salivary gland morphogenesis	IEA	biological process
GO:0060693	regulation of branching i nvolved in salivary gland morphogenesis	IEA	biological process
GO:0061048	negative regulation of br anching involved in lung morphogenesis	IDA	biological process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	NAS	biological process
GO:0071222	cellular response to lipo polysaccharide	IEA	biological process
GO:0071230	cellular response to amin o acid stimulus	IEA	biological process
GO:0071316	cellular response to nico tine	IDA	biological process
GO:0071407	cellular response to orga nic cyclic compound	IDA	biological process
GO:0071550	death-inducing signaling complex assembly	TAS	biological process
GO:0071677	positive regulation of mo nonuclear cell migration	NAS	biological process
GO:0071803	positive regulation of po dosome assembly	IDA	biological process
GO:0090002	establishment of protein localization to plasma me mbrane	IDA	biological process
GO:0097190	apoptotic signaling pathw ay	IEA	biological process
GO:0097191	extrinsic apoptotic signa ling pathway	IEA	biological process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IEA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:1901224	positive regulation of NI K/NF-kappaB signaling	IDA	biological process
GO:1901671	positive regulation of su peroxide dismutase activi ty	IDA	biological process
GO:1903140	regulation of establishme nt of endothelial barrier	IDA	biological process
GO:1903347	negative regulation of bi cellular tight junction a ssembly	IDA	biological process
GO:1904999	positive regulation of le ukocyte adhesion to arter ial endothelial cell	IDA	biological process
GO:2000010	positive regulation of pr otein localization to cel l surface	IDA	biological process
GO:2000304	positive regulation of ce ramide biosynthetic proce ss	TAS	biological process
GO:2000334	positive regulation of bl ood microparticle formati on	IDA	biological process
GO:2000343	positive regulation of ch emokine (C-X-C motif) lig and 2 production	IDA	biological process
GO:2000377	regulation of reactive ox ygen species metabolic pr ocess	IEA	biological process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological process
GO:0000060	protein import into nucle us, translocation	IDA	biological process
GO:0000122	negative regulation of tr anscription from RNA poly merase II promoter	IDA	biological process
GO:0000165	MAPK cascade	IMP	biological process
GO:0000185	activation of MAPKKK acti vity	IDA	biological process
GO:0000187	activation of MAPK activi ty	IDA	biological process
GO:0001819	positive regulation of cy tokine production	IDA	biological process
GO:0001891	phagocytic cup	ISS	cellular component
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological process
GO:0002020	protease binding	IPI	molecular function
GO:0002439	chronic inflammatory resp onse to antigenic stimulu s	IMP	biological process
GO:0002740	negative regulation of cy tokine secretion involved in immune response	IDA	biological process
GO:0005125	cytokine activity	IDA	molecular function
GO:0005164	tumor necrosis factor rec eptor binding	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005887	integral component of pla sma membrane	IDA	cellular component
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IDA	biological process
GO:0006927	obsolete transformed cell apoptotic process	IDA	biological process
GO:0006954	inflammatory response	IDA	biological process
GO:0006954	inflammatory response	IDA	biological process
GO:0006954	inflammatory response	IDA	biological process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	TAS	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	NAS	biological process
GO:0009615	response to virus	IDA	biological process
GO:0009651	response to salt stress	TAS	biological process
GO:0009897	external side of plasma m embrane	ISS	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0010628	positive regulation of ge ne expression	IMP	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IMP	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010629	negative regulation of ge ne expression	IDA	biological process
GO:0010629	negative regulation of ge ne expression	IDA	biological process
GO:0010803	regulation of tumor necro sis factor-mediated signa ling pathway	TAS	biological process
GO:0010888	negative regulation of li pid storage	NAS	biological process
GO:0030730	sequestering of triglycer ide	IDA	biological process
GO:0030866	cortical actin cytoskelet on organization	IDA	biological process
GO:0031334	positive regulation of pr otein complex assembly	IDA	biological process
GO:0031622	positive regulation of fe ver generation	ISS	biological process
GO:0031663	lipopolysaccharide-mediat ed signaling pathway	IDA	biological process
GO:0032715	negative regulation of in terleukin-6 production	IDA	biological process
GO:0032722	positive regulation of ch emokine production	IDA	biological process
GO:0032757	positive regulation of in terleukin-8 production	IMP	biological process
GO:0032800	receptor biosynthetic pro cess	IDA	biological process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	IMP	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological process
GO:0035509	negative regulation of my osin-light-chain-phosphat ase activity	IDA	biological process
GO:0042346	positive regulation of NF -kappaB import into nucle us	IDA	biological process
GO:0042802	identical protein binding	IDA	molecular function
GO:0043065	positive regulation of ap optotic process	IDA	biological process
GO:0043065	positive regulation of ap optotic process	IDA	biological process
GO:0043065	positive regulation of ap optotic process	IDA	biological process
GO:0043065	positive regulation of ap optotic process	IMP	biological process
GO:0043068	positive regulation of pr ogrammed cell death	IDA	biological process
GO:0043122	regulation of I-kappaB ki nase/NF-kappaB signaling	IDA	biological process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological process
GO:0043242	negative regulation of pr otein complex disassembly	IDA	biological process
GO:0043243	positive regulation of pr otein complex disassembly	IDA	biological process
GO:0043243	positive regulation of pr otein complex disassembly	IDA	biological process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological process
GO:0043491	protein kinase B signalin g	IMP	biological process
GO:0043507	positive regulation of JU N kinase activity	IDA	biological process
GO:0044212	transcription regulatory region DNA binding	IDA	molecular function
GO:0045071	negative regulation of vi ral genome replication	IDA	biological process
GO:0045080	positive regulation of ch emokine biosynthetic proc ess	IDA	biological process
GO:0045121	membrane raft	IDA	cellular component
GO:0045416	positive regulation of in terleukin-8 biosynthetic process	IDA	biological process
GO:0045429	positive regulation of ni tric oxide biosynthetic p rocess	IDA	biological process
GO:0045599	negative regulation of fa t cell differentiation	NAS	biological process
GO:0045672	positive regulation of os teoclast differentiation	IDA	biological process
GO:0045785	positive regulation of ce ll adhesion	IMP	biological process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IGI	biological process
GO:0045944	positive regulation of tr anscription from RNA poly merase II promoter	IDA	biological process
GO:0048566	embryonic digestive tract development	IEP	biological process
GO:0048661	positive regulation of sm ooth muscle cell prolifer ation	IDA	biological process
GO:0050715	positive regulation of cy tokine secretion	IDA	biological process
GO:0050766	positive regulation of ph agocytosis	IMP	biological process
GO:0050796	regulation of insulin sec retion	IDA	biological process
GO:0050901	leukocyte tethering or ro lling	IDA	biological process
GO:0050995	negative regulation of li pid catabolic process	IDA	biological process
GO:0051044	positive regulation of me mbrane protein ectodomain proteolysis	IDA	biological process
GO:0051091	positive regulation of se quence-specific DNA bindi ng transcription factor a ctivity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IMP	biological process
GO:0051222	positive regulation of pr otein transport	IDA	biological process
GO:0051384	response to glucocorticoi d	IDA	biological process
GO:0051533	positive regulation of NF AT protein import into nu cleus	IDA	biological process
GO:0055037	recycling endosome	ISS	cellular component
GO:0060557	positive regulation of vi tamin D biosynthetic proc ess	IDA	biological process
GO:0060559	positive regulation of ca lcidiol 1-monooxygenase a ctivity	IDA	biological process
GO:0061048	negative regulation of br anching involved in lung morphogenesis	IDA	biological process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	NAS	biological process
GO:0071316	cellular response to nico tine	IDA	biological process
GO:0071407	cellular response to orga nic cyclic compound	IDA	biological process
GO:0071550	death-inducing signaling complex assembly	TAS	biological process
GO:0071677	positive regulation of mo nonuclear cell migration	NAS	biological process
GO:0071803	positive regulation of po dosome assembly	IDA	biological process
GO:0090002	establishment of protein localization to plasma me mbrane	IDA	biological process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:1901224	positive regulation of NI K/NF-kappaB signaling	IDA	biological process
GO:1901671	positive regulation of su peroxide dismutase activi ty	IDA	biological process
GO:1903140	regulation of establishme nt of endothelial barrier	IDA	biological process
GO:1903347	negative regulation of bi cellular tight junction a ssembly	IDA	biological process
GO:1904999	positive regulation of le ukocyte adhesion to arter ial endothelial cell	IDA	biological process
GO:2000010	positive regulation of pr otein localization to cel l surface	IDA	biological process
GO:2000304	positive regulation of ce ramide biosynthetic proce ss	TAS	biological process
GO:2000334	positive regulation of bl ood microparticle formati on	IDA	biological process
GO:2000343	positive regulation of ch emokine (C-X-C motif) lig and 2 production	IDA	biological process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological process
GO:1901224	positive regulation of NI K/NF-kappaB signaling	IDA	biological process
GO:1901647	positive regulation of sy noviocyte proliferation	IDA	biological process
GO:0150125	positive regulation of in terleukin-33 biosynthetic process	IDA	biological process
GO:1900017	positive regulation of cy tokine production involve d in inflammatory respons e	IDA	biological process
GO:0045416	positive regulation of in terleukin-8 biosynthetic process	IDA	biological process
GO:0045416	positive regulation of in terleukin-8 biosynthetic process	IDA	biological process
GO:1903799	negative regulation of pr oduction of miRNAs involv ed in gene silencing by m iRNA	IDA	biological process
GO:1903799	negative regulation of pr oduction of miRNAs involv ed in gene silencing by m iRNA	IDA	biological process
GO:0005164	tumor necrosis factor rec eptor binding	IPI	molecular function
GO:1903721	positive regulation of I- kappaB phosphorylation	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010629	negative regulation of ge ne expression	IDA	biological process
GO:0060252	positive regulation of gl ial cell proliferation	IDA	biological process
GO:0010629	negative regulation of ge ne expression	IDA	biological process
GO:0031327	negative regulation of ce llular biosynthetic proce ss	IDA	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	IDA	biological process
GO:0050725	positive regulation of in terleukin-1 beta biosynth etic process	IDA	biological process
GO:0051000	positive regulation of ni tric-oxide synthase activ ity	IC	biological process
GO:0032755	positive regulation of in terleukin-6 production	IDA	biological process
GO:0006357	regulation of transcripti on by RNA polymerase II	ISS	biological process
GO:2000351	regulation of endothelial cell apoptotic process	IMP	biological process
GO:2000484	positive regulation of in terleukin-8 secretion	IGI	biological process
GO:1900017	positive regulation of cy tokine production involve d in inflammatory respons e	IGI	biological process
GO:0150078	positive regulation of ne uroinflammatory response	TAS	biological process
GO:0150078	positive regulation of ne uroinflammatory response	TAS	biological process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	ISS	biological process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	TAS	biological process
GO:1903078	positive regulation of pr otein localization to pla sma membrane	ISS	biological process
GO:1903078	positive regulation of pr otein localization to pla sma membrane	ISS	biological process
GO:1902004	positive regulation of am yloid-beta formation	ISS	biological process
GO:0010628	positive regulation of ge ne expression	ISS	biological process
GO:0010628	positive regulation of ge ne expression	ISS	biological process
GO:1900222	negative regulation of am yloid-beta clearance	ISS	biological process
GO:0045410	positive regulation of in terleukin-6 biosynthetic process	ISS	biological process
GO:0010628	positive regulation of ge ne expression	ISS	biological process
GO:0010628	positive regulation of ge ne expression	IGI	biological process
GO:0010628	positive regulation of ge ne expression	ISS	biological process
GO:0014068	positive regulation of ph osphatidylinositol 3-kina se signaling	ISS	biological process
GO:0042531	positive regulation of ty rosine phosphorylation of STAT protein	ISS	biological process
GO:0043154	negative regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IGI	biological process
GO:0043525	positive regulation of ne uron apoptotic process	ISS	biological process
GO:2001234	negative regulation of ap optotic signaling pathway	IGI	biological process
GO:0050729	positive regulation of in flammatory response	TAS	biological process
GO:0050768	negative regulation of ne urogenesis	TAS	biological process
GO:0060252	positive regulation of gl ial cell proliferation	IGI	biological process
GO:0050806	positive regulation of sy naptic transmission	ISS	biological process
GO:0050806	positive regulation of sy naptic transmission	ISS	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	ISS	biological process
GO:0051173	positive regulation of ni trogen compound metabolic process	ISS	biological process
GO:0010629	negative regulation of ge ne expression	IGI	biological process
GO:0045598	regulation of fat cell di fferentiation	ISS	biological process
GO:0046427	positive regulation of re ceptor signaling pathway via JAK-STAT	ISS	biological process
GO:0048143	astrocyte activation	NAS	biological process
GO:0001774	microglial cell activatio n	NAS	biological process
GO:0001774	microglial cell activatio n	ISS	biological process
GO:0050807	regulation of synapse org anization	ISS	biological process
GO:0050890	cognition	TAS	biological process
GO:0045944	positive regulation of tr anscription by RNA polyme rase II	ISS	biological process
GO:0051897	positive regulation of pr otein kinase B signaling	ISS	biological process
GO:0051966	regulation of synaptic tr ansmission, glutamatergic	TAS	biological process
GO:0032603	fractalkine production	ISS	biological process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	ISS	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IBA	biological process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IBA	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	IBA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IBA	biological process
GO:0005615	extracellular space	IBA	cellular component
GO:0005125	cytokine activity	IBA	molecular function
GO:0045944	positive regulation of tr anscription by RNA polyme rase II	IBA	biological process
GO:0009986	cell surface	IBA	cellular component
GO:0005164	tumor necrosis factor rec eptor binding	IBA	molecular function
GO:0048566	embryonic digestive tract development	IEP	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological process
GO:0043243	positive regulation of pr otein-containing complex disassembly	IDA	biological process
GO:0010573	vascular endothelial grow th factor production	IDA	biological process
GO:0043507	positive regulation of JU N kinase activity	IDA	biological process
GO:0043242	negative regulation of pr otein-containing complex disassembly	IDA	biological process
GO:0043065	positive regulation of ap optotic process	IDA	biological process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological process
GO:0005164	tumor necrosis factor rec eptor binding	IEA	molecular function
GO:0006955	immune response	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005125	cytokine activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of mem brane	IEA	cellular component
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0070886	positive regulation of ca lcineurin-NFAT signaling cascade	IDA	biological process
GO:0000122	negative regulation of tr anscription by RNA polyme rase II	IDA	biological process
GO:0045944	positive regulation of tr anscription by RNA polyme rase II	IGI	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0045732	positive regulation of pr otein catabolic process	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological process
GO:0043065	positive regulation of ap optotic process	IMP	biological process
GO:0050766	positive regulation of ph agocytosis	IMP	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007249	I-kappaB kinase/NF-kappaB signaling	TAS	biological process
GO:0010803	regulation of tumor necro sis factor-mediated signa ling pathway	TAS	biological process
GO:0071550	death-inducing signaling complex assembly	TAS	biological process
GO:2000304	positive regulation of ce ramide biosynthetic proce ss	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0019221	cytokine-mediated signali ng pathway	TAS	biological process
GO:0019221	cytokine-mediated signali ng pathway	TAS	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0009887	animal organ morphogenesi s	IEA	biological process
GO:0010033	response to organic subst ance	IEA	biological process
GO:0010628	positive regulation of ge ne expression	IEA	biological process
GO:0032755	positive regulation of in terleukin-6 production	IEA	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	IEA	biological process
GO:0042127	regulation of cell popula tion proliferation	IEA	biological process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IEA	biological process
GO:0045121	membrane raft	IEA	cellular component
GO:0045662	negative regulation of my oblast differentiation	IEA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IEA	biological process
GO:0045994	positive regulation of tr anslational initiation by iron	IEA	biological process
GO:0050727	regulation of inflammator y response	IEA	biological process
GO:0050806	positive regulation of sy naptic transmission	IEA	biological process
GO:0050830	defense response to Gram- positive bacterium	IEA	biological process
GO:0050900	leukocyte migration	IEA	biological process
GO:0051173	positive regulation of ni trogen compound metabolic process	IEA	biological process
GO:0051798	positive regulation of ha ir follicle development	IEA	biological process
GO:0055037	recycling endosome	IEA	cellular component
GO:0060693	regulation of branching i nvolved in salivary gland morphogenesis	IEA	biological process
GO:0071222	cellular response to lipo polysaccharide	IEA	biological process
GO:0071230	cellular response to amin o acid stimulus	IEA	biological process
GO:0097190	apoptotic signaling pathw ay	IEA	biological process
GO:1902004	positive regulation of am yloid-beta formation	IEA	biological process
GO:1904707	positive regulation of va scular smooth muscle cell proliferation	IEA	biological process
GO:0001891	phagocytic cup	IEA	cellular component
GO:0001937	negative regulation of en dothelial cell proliferat ion	IEA	biological process
GO:0002876	positive regulation of ch ronic inflammatory respon se to antigenic stimulus	IEA	biological process
GO:0002925	positive regulation of hu moral immune response med iated by circulating immu noglobulin	IEA	biological process
GO:0005125	cytokine activity	IEA	molecular function
GO:0005615	extracellular space	IEA	cellular component
GO:0006006	glucose metabolic process	IEA	biological process
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IEA	biological process
GO:0006952	defense response	IEA	biological process
GO:0006959	humoral immune response	IEA	biological process
GO:0007254	JNK cascade	IEA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IEA	biological process
GO:0008630	intrinsic apoptotic signa ling pathway in response to DNA damage	IEA	biological process
GO:0009897	external side of plasma m embrane	IEA	cellular component
GO:0010629	negative regulation of ge ne expression	IEA	biological process
GO:0010693	negative regulation of al kaline phosphatase activi ty	IEA	biological process
GO:0030198	extracellular matrix orga nization	IEA	biological process
GO:0030316	osteoclast differentiatio n	IEA	biological process
GO:0031622	positive regulation of fe ver generation	IEA	biological process
GO:0032729	positive regulation of in terferon-gamma production	IEA	biological process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IEA	biological process
GO:0042742	defense response to bacte rium	IEA	biological process
GO:0043525	positive regulation of ne uron apoptotic process	IEA	biological process
GO:0045123	cellular extravasation	IEA	biological process
GO:0045668	negative regulation of os teoblast differentiation	IEA	biological process
GO:0045670	regulation of osteoclast differentiation	IEA	biological process
GO:0045930	negative regulation of mi totic cell cycle	IEA	biological process
GO:0045944	positive regulation of tr anscription by RNA polyme rase II	IEA	biological process
GO:0046325	negative regulation of gl ucose import	IEA	biological process
GO:0046330	positive regulation of JN K cascade	IEA	biological process
GO:0050708	regulation of protein sec retion	IEA	biological process
GO:0050807	regulation of synapse org anization	IEA	biological process
GO:0051023	regulation of immunoglobu lin secretion	IEA	biological process
GO:0051897	positive regulation of pr otein kinase B signaling	IEA	biological process
GO:0060664	epithelial cell prolifera tion involved in salivary gland morphogenesis	IEA	biological process
GO:0072577	endothelial cell apoptoti c process	IEA	biological process
GO:0097191	extrinsic apoptotic signa ling pathway	IEA	biological process
GO:0097527	necroptotic signaling pat hway	IEA	biological process
GO:1900222	negative regulation of am yloid-beta clearance	IEA	biological process
GO:1901224	positive regulation of NI K/NF-kappaB signaling	IEA	biological process
GO:1903078	positive regulation of pr otein localization to pla sma membrane	IEA	biological process
GO:2000377	regulation of reactive ox ygen species metabolic pr ocess	IEA	biological process
GO:0000122	negative regulation of tr anscription by RNA polyme rase II	IEA	biological process
GO:0001774	microglial cell activatio n	IEA	biological process
GO:0001932	regulation of protein pho sphorylation	IEA	biological process
GO:0002020	protease binding	IEA	molecular function
GO:0005164	tumor necrosis factor rec eptor binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0006954	inflammatory response	IEA	biological process
GO:0007275	multicellular organism de velopment	IEA	biological process
GO:1901671	positive regulation of su peroxide dismutase activi ty	IDA	biological process
GO:1902895	positive regulation of pr i-miRNA transcription by RNA polymerase II	IDA	biological process
GO:0010629	negative regulation of ge ne expression	IDA	biological process
GO:0010629	negative regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0005125	cytokine activity	IDA	molecular function
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0006954	inflammatory response	IDA	biological process
GO:1904999	positive regulation of le ukocyte adhesion to arter ial endothelial cell	IDA	biological process
GO:0010629	negative regulation of ge ne expression	IDA	biological process
GO:0005164	tumor necrosis factor rec eptor binding	IDA	molecular function
GO:0042802	identical protein binding	IDA	molecular function
GO:0002020	protease binding	IPI	molecular function
GO:0000185	activation of MAPKKK acti vity	IDA	biological process
GO:0000187	activation of MAPK activi ty	IDA	biological process
GO:0001819	positive regulation of cy tokine production	IDA	biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological process
GO:0009615	response to virus	IDA	biological process
GO:0031334	positive regulation of pr otein-containing complex assembly	IDA	biological process
GO:0032722	positive regulation of ch emokine production	IDA	biological process
GO:0032800	receptor biosynthetic pro cess	IDA	biological process
GO:0043122	regulation of I-kappaB ki nase/NF-kappaB signaling	IDA	biological process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological process
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological process
GO:0043243	positive regulation of pr otein-containing complex disassembly	IDA	biological process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological process
GO:0043406	positive regulation of MA P kinase activity	IDA	biological process
GO:0045071	negative regulation of vi ral genome replication	IDA	biological process
GO:0045080	positive regulation of ch emokine biosynthetic proc ess	IDA	biological process
GO:0045121	membrane raft	IDA	cellular component
GO:0045416	positive regulation of in terleukin-8 biosynthetic process	IDA	biological process
GO:0045672	positive regulation of os teoclast differentiation	IDA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological process
GO:0050715	positive regulation of cy tokine secretion	IDA	biological process
GO:0050995	negative regulation of li pid catabolic process	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0051222	positive regulation of pr otein transport	IDA	biological process
GO:0051384	response to glucocorticoi d	IDA	biological process
GO:0060559	positive regulation of ca lcidiol 1-monooxygenase a ctivity	IDA	biological process
GO:0071803	positive regulation of po dosome assembly	IDA	biological process
GO:2000343	positive regulation of ch emokine (C-X-C motif) lig and 2 production	IDA	biological process
GO:0001891	phagocytic cup	ISS	cellular component
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	NAS	biological process
GO:0009651	response to salt stress	TAS	biological process
GO:0010888	negative regulation of li pid storage	NAS	biological process
GO:0033209	tumor necrosis factor-med iated signaling pathway	IMP	biological process
GO:0045599	negative regulation of fa t cell differentiation	NAS	biological process
GO:0055037	recycling endosome	ISS	cellular component
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological process
GO:0002740	negative regulation of cy tokine production involve d in immune response	IDA	biological process
GO:0005887	integral component of pla sma membrane	IDA	cellular component
GO:0006954	inflammatory response	IDA	biological process
GO:0009986	cell surface	IDA	cellular component
GO:0030730	sequestering of triglycer ide	IDA	biological process
GO:0032715	negative regulation of in terleukin-6 production	IDA	biological process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological process
GO:0033138	positive regulation of pe ptidyl-serine phosphoryla tion	IDA	biological process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological process
GO:0034116	positive regulation of he terotypic cell-cell adhes ion	IDA	biological process
GO:1901224	positive regulation of NI K/NF-kappaB signaling	IDA	biological process
GO:0045429	positive regulation of ni tric oxide biosynthetic p rocess	IDA	biological process
GO:0045944	positive regulation of tr anscription by RNA polyme rase II	IDA	biological process
GO:0048661	positive regulation of sm ooth muscle cell prolifer ation	IDA	biological process
GO:0050796	regulation of insulin sec retion	IDA	biological process
GO:0050901	leukocyte tethering or ro lling	IDA	biological process
GO:0051044	positive regulation of me mbrane protein ectodomain proteolysis	IDA	biological process
GO:0051091	positive regulation of DN A-binding transcription f actor activity	IDA	biological process
GO:0060557	positive regulation of vi tamin D biosynthetic proc ess	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:2000010	positive regulation of pr otein localization to cel l surface	IDA	biological process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological process
GO:2001240	negative regulation of ex trinsic apoptotic signali ng pathway in absence of ligand	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0061044	negative regulation of va scular wound healing	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:1904996	positive regulation of le ukocyte adhesion to vascu lar endothelial cell	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0002439	chronic inflammatory resp onse to antigenic stimulu s	IMP	biological process
GO:0009897	external side of plasma m embrane	ISS	cellular component
GO:0031622	positive regulation of fe ver generation	ISS	biological process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	NAS	biological process
GO:0071677	positive regulation of mo nonuclear cell migration	NAS	biological process
GO:2000334	positive regulation of bl ood microparticle formati on	IDA	biological process
GO:0043537	negative regulation of bl ood vessel endothelial ce ll migration	IDA	biological process
GO:0010629	negative regulation of ge ne expression	IDA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:1903140	regulation of establishme nt of endothelial barrier	IDA	biological process
GO:0072659	protein localization to p lasma membrane	IDA	biological process
GO:0030866	cortical actin cytoskelet on organization	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0000976	transcription regulatory region sequence-specific DNA binding	IDA	molecular function
GO:0043068	positive regulation of pr ogrammed cell death	IDA	biological process
GO:0006919	activation of cysteine-ty pe endopeptidase activity involved in apoptotic pr ocess	IDA	biological process
GO:1901224	positive regulation of NI K/NF-kappaB signaling	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:0097527	necroptotic signaling pat hway	IDA	biological process
GO:0071407	cellular response to orga nic cyclic compound	IDA	biological process
GO:0001934	positive regulation of pr otein phosphorylation	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0071316	cellular response to nico tine	IDA	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IDA	biological process
GO:0045893	positive regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological process
GO:0045892	negative regulation of tr anscription, DNA-template d	IDA	biological process
GO:0043280	positive regulation of cy steine-type endopeptidase activity involved in apo ptotic process	IDA	biological process
GO:0008625	extrinsic apoptotic signa ling pathway via death do main receptors	IDA	biological process
GO:0035509	negative regulation of my osin-light-chain-phosphat ase activity	IDA	biological process
GO:1903347	negative regulation of bi cellular tight junction a ssembly	IDA	biological process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological process
GO:0097191	extrinsic apoptotic signa ling pathway	IDA	biological process
GO:0061048	negative regulation of br anching involved in lung morphogenesis	IDA	biological process
GO:0045944	positive regulation of tr anscription by RNA polyme rase II	IDA	biological process
GO:0043065	positive regulation of ap optotic process	IDA	biological process
GO:0043065	positive regulation of ap optotic process	IDA	biological process
GO:0031663	lipopolysaccharide-mediat ed signaling pathway	IDA	biological process
GO:0010629	negative regulation of ge ne expression	IDA	biological process
GO:0006954	inflammatory response	IDA	biological process
GO:0000122	negative regulation of tr anscription by RNA polyme rase II	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IDA	biological process
GO:0010628	positive regulation of ge ne expression	IMP	biological process
GO:0010628	positive regulation of ge ne expression	IMP	biological process
GO:0045785	positive regulation of ce ll adhesion	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0043491	protein kinase B signalin g	IMP	biological process
GO:0000165	MAPK cascade	IMP	biological process
GO:0032757	positive regulation of in terleukin-8 production	IMP	biological process
GO:0051092	positive regulation of NF -kappaB transcription fac tor activity	IMP	biological process

KEGG pathways

Expand All | Collapse All

Pathway id	Pathway name
hsa05168	Herpes simplex virus 1 infection
hsa05010	Alzheimer disease
hsa05165	Human papillomavirus infection
hsa04010	MAPK signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa05131	Shigellosis
hsa05132	Salmonella infection
hsa05166	Human T-cell leukemia virus 1 infection
hsa05163	Human cytomegalovirus infection
hsa05130	Pathogenic Escherichia coli infection
hsa05170	Human immunodeficiency virus 1 infection
hsa05205	Proteoglycans in cancer
hsa05169	Epstein-Barr virus infection
hsa04621	NOD-like receptor signaling pathway
hsa04150	mTOR signaling pathway
hsa05152	Tuberculosis
hsa04217	Necroptosis
hsa04932	Non-alcoholic fatty liver disease
hsa05164	Influenza A
hsa05161	Hepatitis B
hsa04380	Osteoclast differentiation
hsa05160	Hepatitis C
hsa05418	Fluid shear stress and atherosclerosis
hsa05322	Systemic lupus erythematosus
hsa05135	Yersinia infection
hsa04210	Apoptosis
hsa04071	Sphingolipid signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04668	TNF signaling pathway
hsa04064	NF-kappa B signaling pathway
hsa04625	C-type lectin receptor signaling pathway
hsa04660	T cell receptor signaling pathway
hsa04931	Insulin resistance
hsa04061	Viral protein interaction with cytokine and cytokine receptor
hsa05414	Dilated cardiomyopathy
hsa04620	Toll-like receptor signaling pathway
hsa04350	TGF-beta signaling pathway
hsa05145	Toxoplasmosis
hsa05410	Hypertrophic cardiomyopathy
hsa05142	Chagas disease
hsa04933	AGE-RAGE signaling pathway in diabetic complications
hsa05146	Amoebiasis
hsa04640	Hematopoietic cell lineage
hsa04657	IL-17 signaling pathway
hsa05323	Rheumatoid arthritis
hsa04622	RIG-I-like receptor signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa05133	Pertussis
hsa05140	Leishmaniasis
hsa04612	Antigen processing and presentation
hsa04930	Type II diabetes mellitus
hsa05014	Amyotrophic lateral sclerosis
hsa05134	Legionellosis
hsa05321	Inflammatory bowel disease
hsa05144	Malaria
hsa01523	Antifolate resistance
hsa05143	African trypanosomiasis
hsa04940	Type I diabetes mellitus
hsa05310	Asthma
hsa05332	Graft-versus-host disease
hsa05330	Allograft rejection
hsa04064	NF-kappa B signaling pathway
hsa04668	TNF signaling pathway
hsa04071	Sphingolipid signaling pathway
hsa04150	mTOR signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04061	Viral protein interaction with cytokine and cytokine receptor
hsa04210	Apoptosis
hsa04217	Necroptosis
hsa04640	Hematopoietic cell lineage
hsa04620	Toll-like receptor signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa04625	C-type lectin receptor signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04612	Antigen processing and presentation
hsa04660	T cell receptor signaling pathway
hsa04657	IL-17 signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa04380	Osteoclast differentiation
hsa05205	Proteoglycans in cancer
hsa05310	Asthma
hsa05322	Systemic lupus erythematosus
hsa05323	Rheumatoid arthritis
hsa05321	Inflammatory bowel disease
hsa05330	Allograft rejection
hsa05332	Graft-versus-host disease
hsa05010	Alzheimer disease
hsa05014	Amyotrophic lateral sclerosis
hsa05418	Fluid shear stress and atherosclerosis
hsa05410	Hypertrophic cardiomyopathy
hsa05414	Dilated cardiomyopathy
hsa04930	Type II diabetes mellitus
hsa04940	Type I diabetes mellitus
hsa04932	Non-alcoholic fatty liver disease
hsa04931	Insulin resistance
hsa04933	AGE-RAGE signaling pathway in diabetic complications
hsa05130	Pathogenic Escherichia coli infection
hsa05135	Yersinia infection
hsa05133	Pertussis
hsa05134	Legionellosis
hsa05152	Tuberculosis
hsa05166	Human T-cell leukemia virus 1 infection
hsa05170	Human immunodeficiency virus 1 infection
hsa05164	Influenza A
hsa05161	Hepatitis B
hsa05160	Hepatitis C
hsa05168	Herpes simplex virus 1 infection
hsa05163	Human cytomegalovirus infection
hsa05169	Epstein-Barr virus infection
hsa05165	Human papillomavirus infection
hsa05146	Amoebiasis
hsa05144	Malaria
hsa05145	Toxoplasmosis
hsa05140	Leishmaniasis
hsa05142	Chagas disease
hsa05143	African trypanosomiasis
hsa01523	Antifolate resistance

Diseases

Expand All | Collapse All

Associated diseases	References
Brill-Symmers disease	GAD: 20578820
Cancer	GAD: 18319718
Cancer (adenocarcinoma)	GAD: 19152246
Cancer (basal cell)	GAD: 12490310
Cancer (B-Cell lymphomas)	GAD: 16393214
Cancer (Biliary tract neoplasms)	GAD: 18676870
Cancer (bladder)	GAD: 16110031
Cancer (cervical)	GAD: 12142377
Cancer (chronic B-Cell Leukemias)	GAD: 16426238
Cancer (colorectal)	GAD: 12433710
Cancer (epithelial ovarian)	GAD: 19064572
Cancer (esophageal)	GAD: 16313841
Cancer (gastric)	GAD: 12891537
Cancer (glaucoma)	GAD: 19556827
Cancer (head and neck)	GAD: 17560079
Cancer (Hepatocellular)	GAD: 18603357
Cancer (kidney)	GAD: 15784411
Cancer (leiomyoma)	GAD: 15474092
Cancer (leukemia)	GAD: 12047360
Cancer (liver)	GAD: 15763337
Cancer (lung)	GAD: 20486865
Cancer (lymphoma)	GAD: 15146559
Cancer (melanoma)	GAD: 11841484
Cancer (myeloma)	GAD: 17315188
Cancer (nasal polyps)	GAD: 19344623
Cancer (nasopharyngeal)	GAD: 12691826
Cancer (noncardia gastric)	GAD: 14753224
Cancer (non-hodgkin lymphoma)	GAD: 16389181
Cancer (oral)	GAD: 15799583
Cancer (osteosarcoma)	GAD: 17483704
Cancer (ovarian)	GAD: 20628624
Cancer (pancreatic)	GAD: 16614115
Cancer (prostate)	GAD: 12067976
Cancer (Renal cell)	GAD: 19658300
Cancer (Squamous cell)	GAD: 19495883
Cancer (stomach)	GAD: 15579481
Cancer (testicular)	GAD: 17220333
Cancer (breast)	GAD: 15265021
Aneurysm	GAD: 18600213
Angina pectoris	GAD: 19005292
Aortic diseases	GAD: 17079017
Apoplexy	GAD: 20493182
Atherosclerosis	GAD: 16386648
Atrial fibrillation	GAD: 20490891
Brain ischemia	GAD: 19028820
Hypertension	GAD: 12009575
Intracranial aneurysm	GAD: 17415203
Cardiovascular disease	GAD: 16100725
Carotid artery diseases	GAD: 15992611
Cerebral hemorrhage	GAD: 20534169
Cerebral infarction	GAD: 14992821
Cerebrovascular disease	GAD: 12871600
Restenosis	GAD: 12899665
Thromboembolism	GAD: 17113632
Systemic vasculitis	GAD: 10729297
Limb deficiency defects	GAD: 17036337
Omenn syndrome severe combined immunideficiency	GAD: 17572155
Hemochromatosis	GAD: 12940442
Gout	GAD: 17631734
Down syndrome	GAD: 15308304
Fabry disease	GAD: 17353161
Bronchopulmonary dysplasia	GAD: 18645461
Cystic fibrosis	GAD: 17336597
Liver disease	GAD: 12654235
Irritable bowel syndrome	GAD: 19844779
Gastric disease	GAD: 19295440
Primary biliary cirrhosis	GAD: 12911663
Primary biliary cirrhosis	GAD: 10453936
Primary sclerosing cholangitis	GAD: 10068102
Liver disease	GAD: 11192323
Sclerosing cholangitis	GAD: 14567462
Chronic pancreatitis	GAD: 12828656
Hashimoto disease	GAD: 17115419
Polyendocrinopathies	GAD: 19811436
Graves disease	GAD: 16313297
Graves ophthalmopathy	GAD: 16191343
Diabetic nephropathy	GAD: 17428349
Ophthalmia	GAD: 16249504
Glaucoma	GAD: 12579167
Macular degeneration	GAD: 21060270
Retinopathy	GAD: 15161830
Pterygium	GAD: 15184943
Pterygium	GAD: 15184943
Uveitis	GAD: 15851552
Chorioretinitis	GAD: 18577652
Exfoliation syndrome	GAD: 18852869
Eye diseases	GAD: 18447907
AHG deficiency disease	GAD: 19686262
Anemia	GAD: 18716131
Beta-thalassemia	GAD: 19103526
Myelodysplastic syndrome	GAD: 16400883
Hemophilia	GAD: 19817985
Sarcoidosis	GAD: 11243953
Neutropenia	GAD: 15986200
Mucocutaneous lymph node syndrome	GAD: 20202153
Henoch-Schonlein purpura	GAD: 15257453
Hodgkin disease	GAD: 12014672
Lymphoproliferative disorders	GAD: 16824159
Chronic immune thrombocytopenic purpura	GAD: 15009068
Idiopathic thrombocytopenic purpura	GAD: 20626741
Kawasaki disease	GAD: 14744383
Acne Vulgaris	GAD: 18615253
Allergic rhinitis	GAD: 15120189
Allergy	GAD: 11354638
Alveolitis	GAD: 16722148
Ankylosing spondylitis	GAD: 12118167
Antiphospholipid syndrome	GAD: 11246532
Arthritis	GAD: 11981324
Asthma	GAD: 11202474
Atopy	GAD: 10371104
Autoimmune diseases	GAD: 12960355
Behcet's disease	GAD: 14727453
Behcet's disease	GAD: 18355201
Bronchial hyperreactivity	GAD: 10469028
Bullous pemphigoid	GAD: 16403098
Inflammatory bowel disease	GAD: 15842590
Juvenile arthritis	GAD: 12223104
Ulcerative colitis	GAD: 16116311
Multiple sclerosis	GAD: 16183136
Rheumatoid arthritis	GAD: 15077289
Periodontitis	GAD: 19148387
Ulcerative colitis	GAD: 11904678
Periodontitis	GAD: 15842262
Psoriasis	GAD: 12653732
Inflammatory polyarthritis	GAD: 14962963
Scleroderma	GAD: 20603050
Systemic lupus erythematosus (SLE)	GAD: 18069935
Systemic lupus erythematosus (SLE)	KEGG: H00080
Celiac disease	MIK: 25915602
Chronic ulcerative colitis	GAD: 14617036
Crohn's disease	GAD: 14646574
Hypersensitivity	GAD: 15127972
Amyloidosis	GAD: 14696796
Biliary cirrhosis	GAD: 20578265
Fatty liver	GAD: 18565022
Metabolic syndrome	GAD: 15978856
Obesity	GAD: 10904006
Insulin resistance	GAD: 10916281
Diabetes	GAD: 11891022
Hyperlipidemias	GAD: 17981921
Dyslipidemias	GAD: 17700364
Bone diseases	GAD: 12240899
Knee osteoarthritis	GAD: 19934104
Osteoarthritis	GAD: 11083263
Osteolysis	GAD: 19860911
Osteoporosis	GAD: 18551993
Rheumatoid spondylitis	GAD: 17472990
Polymyositis	GAD: 15022353
Dermatomyositis	GAD: 12173300
Sleep disorders	GAD: 16204600
Multiple system atrophy	GAD: 15663966
Migraine disorder	OMIM: 14718719
Giant cell arteritis	GAD: 12102486
Stroke	GAD: 19168815
Subarachnoid hemorrhage	GAD: 15726267
Myasthenia gravis	GAD: 9688335
Guillain-Barre syndrome	GAD: 20600447
Alzheimer's disease	GAD: 18307033
Amyotrophic lateral sclerosis (ALS)	GAD: 18513389
Parkinson disease	GAD: 18284424
Actinic prurigo	GAD: 11722460
Cerebral palsy	GAD: 19238444
Chronic fatigue syndrome	GAD: 16762155
Attention deficit hyperactivity disorder (ADHD)	GAD: 18580852
Anorexia nervosa	GAD: 18773665
Autism	GAD: 19058789
Bipolar disorder	GAD: 19328558
Mood disorders	GAD: 18832862
Psychological disorders	GAD: 19546559
Schizophrenia	GAD: 16503400
Dementia	OMIM: 191160
Albuminuria	GAD: 21054877
Kidney diseases	GAD: 15104679
Chronic renal failure	GAD: 21085059
Abortion	GAD: 20106534
Hypothyroidism	GAD: 15236755
Miscarriage	GAD: 19778488
Preeclampsia	GAD: 14963369
Preeclampsia	GAD: 16433832
Recurrent pregnancy loss (RPL)	GAD: 14969768
Recurrent pregnancy loss (RPL)	GAD: 12609526
Premature birth	GAD: 17074545
Preterm birth risk	GAD: 15951664
Preeclampsia	GAD: 11349201
Adenomyosis	INFBASE: 12069392
Endometriosis	INFBASE: 23293332
Pelvic adhesions	INFBASE: 11756364
Benign�ovarian�cysts	INFBASE: 15893868
Female infertility	INFBASE: 20008415
Hypergonadotropic hypogonadism	INFBASE: 17507040
Premature ovarian insufficiency (POI)	INFBASE: 22884017
Multiple implantation failures	INFBASE: 12660269
Female infertility	INFBASE: 19706022
Endometriosis	INFBASE: 12845737
Fertilizing defects	INFBASE: 18228126
Adenomyosis	INFBASE: 14597251
Infertility	INFBASE: 11834865
Infertility	INFBASE: 17977210
Oocyte development and maturation	INFBASE: 9513849
Polycystic ovary syndrome (PCOS)	INFBASE: 25186501
Female infertility	INFBASE: 18490014
Primary infertility	INFBASE: 2971579
Reproductive disorderes	INFBASE: 12607776
Endometriosis	INFBASE: 20655530
Recurrent pregnancy loss (RPL)	INFBASE: 25935494
Polycystic ovary syndrome (PCOS)	INFBASE: 25256873
Ovarian dysfunction	INFBASE: 16579166
Ovarian endometriosis	INFBASE: 27337799
Ullrich-Turner�syndrome�(UTS)	INFBASE: 3165234
Ovarian hyperstimulation syndrome (OHSS)	INFBASE: 10783347
Premature ovarian failure (POF)	INFBASE: 8561874
Recurrent pregnancy loss (RPL)	INFBASE: 17482605
Recurrent pregnancy loss (RPL)	INFBASE: 22349103
Asthenozoospermia	MIK: 21218642
Leukocytospermia	MIK: 11839394
Immunoinfertility	MIK: 25032981
Impaired human spermatogenesis	MIK: 19527232
Infertility	MIK: 25351208
Leukocytospermia	MIK: 23209346
Oligoasthenoteratozoospermia	MIK: 23465534
Asthenozoospermia	MIK: 23465534
Asthenoteratozoospermia	MIK: 23465534
Macro-orchidism with or without�hypogonadism�	MIK: 17507040
Male factor infertility	MIK: 11554690
Male subfertility	MIK: 19811461
Asthenozoospermia	MIK: 24029665
Male factor infertility	MIK: 22994050
Male factor infertility	MIK: 17507040
Sperm function	MIK: 7835127
Sperm motility	MIK: 7835127
Sperm motility	MIK: 23209346
Sperm motility	MIK: 1601744
Asthenozoospermia	MIK: 21933900
Sperm�antibodies and human leukocyte antigens in couples with early spontaneous abortions	MIK: 2880818
Male subfertility	MIK: 19811461
Prostatitis	MIK: 24329571
Prostato-vesiculitis	MIK: 24329571
Oligozoospermia	MIK: 11839394
Premature adrenarche	MIK: 22654787
Oligozoospermia	MIK: 24029665
Varicocele	MIK: 25081128
Unexplained infertility	MIK: 25032981
Leukocytospermia	MIK: 25081128
Normozoospermia	MIK: 24029665
Non obstructive azoospermia	MIK: 17507040
IVF outcome	INFBASE: 18228126
Azoospermia	MIK: 21933900
Fertilizing defects	MIK: 3364508
Endometriosis	INFBASE: 20008415
Cell�proliferation and prostaglandin production	INFBASE: 1426379
Chorioamnionitis	GAD: 12850624
Deep infiltrating endometriosis	INFBASE: 11327093
Ectopic endometriosis	INFBASE: 10087426
Effect on fertilization	INFBASE: 24999734
Endometriosis	INFBASE: 23269356
Endometriosis-associated�infertility	INFBASE: 11834864
Interstitial lung diseases	GAD: 19117745
Silicosis	GAD: 15555301
Fibrosing alveolitis	GAD: 10934117
Lung disease	GAD: 15486341
Respiratory tract diseases	GAD: 16688007
Pulmonary fibrosis	GAD: 11371414
Byssinosis	GAD: 17332138
Chronic lung disease	GAD: 12944979
Chronic obstructive pulmonary disease (COPD)	GAD: 18364273
Wegener granulomatosis	GAD: 15708894
Nasal polyposis	GAD: 17638785
Rhinitis	GAD: 21313996
Palmoplantar pustulosis	GAD: 12691703
Vitiligo	GAD: 16691430
Dermatitis	GAD: 12828754
Erythema	GAD: 11411907
Varicose ulcer	GAD: 20854863
Pemphigus vulgaris	GAD: 14617046
Lipodystrophy	GAD: 12478078
Connective tissue diseases	GAD: 19527514
Recurrent aphthous stomatitis	GAD: 12477062
Periodontal disease	GAD: 15341923
Chronic periodontitis	GAD: 12828656
Alpha 1-antitrypsin deficiency	GAD: 18620570
Alveolar bone loss	GAD: 17356374
Asphyxia	GAD: 16181755
Atrophy	GAD: 19448967
Bird fancier's lung	GAD: 11401868
Bronchiolitis	GAD: 17097497
Bronchitis	GAD: 15686588
Femur head necrosis	GAD: 18312678
Respiratory distress syndrome	GAD: 16135717
Cachexia	GAD: 19244371
Chronic idiopathic neutropenia	GAD: 19614955
Early onset psoriasis	GAD: 10201539
Emphysema	GAD: 12661999
Nephropathy	GAD: 11748357
Nephrotic syndrome	GAD: 19008611
Uterine diseases	GAD: 12802709
Systemic lupus erythematosus	KEGG:H00080
Asthma	KEGG:H00079
Systemic lupus erythematosus	KEGG:H00080
Asthma	KEGG:H00079
Stevens-Johnson syndrome	PMID:9852250
Mevalonic aciduria	PMID:7780142
Weill-Marchesani syndrome	PMID:15223607
Hypochromic microcytic anemia	PMID:18205195
Cancer (small cell)	PMID:8624296
Sleep apnea	PMID:20846669
Sleep apnea	PMID:14633242
Sleep apnea	PMID:19022640
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia	PMID:24119107
Myelodysplastic syndrome	PMID:15888251
Atrial fibrillation	PMID:19169931
Lupus nephritis	PMID:7750940
Non-alcoholic fatty liver disease	PMID:25894568
Dilated cardiomyopathy 1H	PMID:14676433
Sensorineural hearing loss	PMID:19684145
Thalassemia	PMID:11732868
Prostate cancer	PMID:19851870
Pre-eclampsia	PMID:15901845
Alzheimer's disease	PMID:18992723
Alzheimer's disease	PMID:9772027
Alzheimer's disease	PMID:12962917
Alzheimer's disease	PMID:16516271
Alzheimer's disease	PMID:16908746
Alzheimer's disease	PMID:18992723
open-angle glaucoma	PMID:20357201
primary open angle glaucoma	PMID:15557444
Hypertension	PMID:16202847
Sickle cell anemia	PMID:8140855
Cholesteatoma of middle ear	PMID:21311206
Intravascular coagulation	PMID:16518755
Trachoma	PMID:17330135
Adult respiratory distress syndrome	PMID:21062445
Adult respiratory distress syndrome	PMID:16135717
Pulmonary edema	PMID:9628235
Cicatricial pemphigoid	PMID:7750940
Diabetic angiopathy	PMID:18575614
iron deficiency anemia	PMID:18716131
Visual epilepsy	PMID:23333565
Primary biliary cirrhosis	PMID:9047083
Beta thalassemia	PMID:19103526
neutropenia	PMID:15986200
Vogt-Koyanagi-Harada disease	PMID:21334264
Vitiligo	PMID:16911396
Graves' disease	PMID:15219383
Graves' disease	PMID:17348243
Graves' disease	PMID:19732761
aplastic anemia	PMID:12941546
hereditary hemorrhagic telangiectasia	PMID:16611101
migraine without aura	PMID:14718719
autistic disorder	PMID:26418275
Sjogren's syndrome	PMID:22703762
Keratoconjunctivitis sicca	PMID:10487957
Cardiomyopathy	PMID:14984724
periventricular leukomalacia	PMID:8652010
Behcet's disease	PMID:21334264
Behcet's disease	PMID:14600787
Behcet's disease	PMID:20601837
Behcet's disease	PMID:12632436
Kawasaki disease	PMID:8777922
Kawasaki disease	PMID:14703611
Kawasaki disease	PMID:14744383
Kawasaki disease	PMID:18710885
pulmonary sarcoidosis	PMID:15653992
pulmonary sarcoidosis	PMID:20070603
low tension glaucoma	PMID:15557444
Fanconi anemia	PMID:8438880
Fanconi anemia	PMID:24021704
Farmer's lung	PMID:8466130
farmer's lung	PMID:11179110
Cystic fibrosis	PMID:7537567
Cystic fibrosis	PMID:21993476
Thrombocytopenia	PMID:25128199
Thrombocytopenia	PMID:16987073
Breast cancer	PMID:19967414
Breast cancer	PMID:18409070
Breast cancer	PMID:17216494
Gaucher's disease	PMID:15919211
Hidradenitis suppurativa	PMID:23106544
Hemochromatosis	PMID:16793930
Hemochromatosis	PMID:11389006
Anemia	PMID:2324681
Multiple sclerosis	PMID:8964914
Multiple sclerosis	PMID:8887999
Ovarian cancer	PMID:19825522
Dermatitis	PMID:3171214
Asthma	PMID:20465535
Asthma	PMID:18711258
Cryoglobulinemia	PMID:19860001
Malignant glioma	PMID:11810046
Chronic obstructive pulmonary disease	PMID:8564092
Chronic obstructive pulmonary disease	PMID:11179116
Atopic dermatitis	PMID:22533231
Coronary artery disease	PMID:15059615
Breast adenocarcinoma	PMID:12536235
Mixed connective tissue disease	PMID:19684145
Cerebral infarction	PMID:16173529
Skin disease	PMID:21357384
Pulmonary fibrosis	PMID:12030733
lung non-small cell carcinoma	PMID:9669810
lung non-small cell carcinoma	PMID:19505916
Liver disease	PMID:11389006
Coronary restenosis	PMID:16319143
cervical cancer	PMID:19823053
Pustulosis of palm and sole	PMID:12691703
renal cell carcinoma	PMID:19904265
renal cell carcinoma	PMID:19384924
Schizophrenia	PMID:15927374
Kidney disease	PMID:14613268
Eye disease	PMID:12186498
congestive heart failure	PMID:11100001
Lymphopenia	PMID:2324681
Acquired immunodeficiency syndrome	PMID:8548330
Pulmonary hypertension	PMID:9628235
Acne	PMID:18615253
hepatocellular carcinoma	PMID:26890368
Rheumatoid arthritis	PMID:12563673
Lung disease	PMID:9462189
Dermatitis herpetiformis	PMID:7914110
Cor pulmonale	PMID:20669672
Vascular dementia	PMID:11273064
Psoriasis	PMID:16821276
Diabetic retinopathy	PMID:16284605
Diabetic retinopathy	PMID:22105495
Psoriatic arthritis	PMID:9326391
Systemic lupus erythematosus	PMID:15642275
Systemic lupus erythematosus	PMID:11607787
Amyloidosis	PMID:14613268
type 2 diabetes mellitus	PMID:28843383
multiple myeloma	PMID:12200397
Bronchiectasis	PMID:18221721
type 1 diabetes mellitus	PMID:19120272
Muscular dystrophy	PMID:10235436
obesity	PMID:28843383
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Asthenozoospermia	MIK: 11839394
Oligozoospermia	MIK: 11839394
Leukocytospermia	MIK: 11839394
Azoospermia	MIK: 21933900
Celiac disease	MIK: 25915602
Endometriosis	MIK: 7835127
Sperm motility defects	MIK: 7835127
Spermatogenic defects	MIK: 19527232
Varicocele	MIK: 25351208
Leukocytospermia	MIK: 23209346
Hypergonadotropic hypogonadism	MIK: 17507040
Male infertility	MIK: 24329571
Prostatitis and prostato-vesiculitis	MIK: 24329571
Premature Adrenarche	MIK: 22654787
Teratozoospermia	MIK: 17327269

PubMed references

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PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
26612435	Male infer tility	TGFB3 (rs2268626:T?>?C, rs3917158:C?>?T, rs2284792:A?>?G, rs2268625:T?>?C, rs3917187:C?>?T) and�TNF�(rs1800629:-308G?>?A)	Polish	846 (423 infert ile�and 423 fer tile men)	Male infertility	TGF-?3	Show abstract
25915602	Celiac dis ease	IFNG�+874A>T (rs2430561) and�TNFA(-1031T>C, rs1799964; -857C>T, rs1799724; -376G>A, rs1800750; -308G>A, rs1800629; -238G>A, rs361525)	Italy	511 (244 Celiac disease, 267 c ontrols)	Male infertility, Female infertility		Show abstract
25351208	Infertile (Patients with varic ocele)		Egyptia n	112 (30 fertile males with var icocele, 44 inf ertile males wi th varicocele a nd 38 healthy f ertile control subjects withou t varicocele)	Male infertility		Show abstract
22994050	Male infer tility			140 (110 infert ile patients an d 30 normal fer tile men)	Male infertility	MIP-1alpha	Show abstract
21218642	Asthenospe rmia	minus 308 genotype polymorphism in the promoter region of TNFalpha gene		187 (infertile male patients, who were divide d into Groups A (asthenospermi a, n = 60), B ( oligoasthenozoo spermia, n = 65 ) and C (infert ile patients wi th normal�sperm , n = 62))	Male infertility		Show abstract
19811461	Male subfe rtility			76 male partner s of an inferti le couple	Male infertility	IL-6 IL-8 IL-10 IL-11 IL-12 �TNF-alpha and IFN-gamma	Show abstract
18689851	Male infer tility	minus 308 genotype polymorphism in the promoter region of TNFalpha gene	Caucasi an and North A frican origin	684 infertile m ale patients un dergoing an int racytoplasmic�s perm�injection procedure	Male infertility		Show abstract
18418000	Male infer tility	TNFalpha -308 C-->T and -863 C-->A polymorphisms	Caucasi an	577 (non-normoz oospermic (n = 447) and normoz oospermic (n = 130))	Male infertility		Show abstract
11554690	Infertilit y			51 (37 infertil e and 14 fertil e men)	Male infertility	IL6	Show abstract
7835127	Endometrio sis/ Sperm motility			34 (16 infertil e women with en dometriosis, 11 infertile wome n without endom etriosis, 7 nor mal fertile wom an)	Male infertility, Female infertility		Show abstract
7928663	Male infer tility			25 (15 infertil e men, 10 ferti le men)	Male infertility	TNF-alpha IFN-gamma IL-1 beta IL-6	Show abstract
15588162	Infertilit y			17	Male infertility		Show abstract
26662429	Celiac dis ease		Italian (North east)	288 ((96 DQ2-po sitive and 96 D Q8-positive), 9 6 controls)	Male infertility, Female infertility	IL-6 TNF-?	Show abstract
24830311	Male infer tility			110 azoospermic men	Male infertility	IL-6 TNF-?	Show abstract
24029665	Normozoosp ermic (idi opathic un explained) , oligozoo spermic an d asthenoz oospermic�	TNF-? G-308A,�IL-6�G-174C substitution	Uttar P radesh populat ion in North I ndia	520 (260 contro ls, 260 inferti le patients)	Male infertility	TNF-? IL-6	Show abstract
21244563	Male infer tility			59 (33 normal g roup, 24abnorma l group, )	Male infertility	IL-23 �IL-6 TNF-?	Show abstract
20576636	Infertilit y			96 (male infert ility, n = 61; female infertil ity factors, n = 35)	Male infertility, Female infertility		Show abstract
22654787	Premature Adrenarche	TNF-? gene -308 G?>?A polymorphism		171 (73 childre n with PA and 9 8 age- and gend er-matched cont rols)	Male infertility, Female infertility	TNF-? IL-6	Show abstract
19811461	Subfertile men			78 male partner s	Male infertility	IL-6 IL-10 TNF-alpha IFN-gamma	Show abstract
19527232	Impaired h uman sperm atogenesis			39 (10 controls , 29 azoospermi c patients (9 S ertoli cell onl y syndrome, 7 u ndefined matura tion arrest, 4 maturation arre st at a spermat ocyte stage, 3 maturation arre st at a spermat id stage and OA , 6 obstructive azospermia ) )	Male infertility	IL-6 IL-10 TNF-alpha TNFR1 and TNFR2	Show abstract
17341438	Oligozoosp ermia, ast henozoospe rmia			62 (34 controls , 28 men with o ligozoospermia or asthenozoosp ermia)	Male infertility	IL-6 IL-8 VEGF TNFalpha IL-1beta TGFbeta1 and G-CSF	Show abstract
11554690	Male infer tility			51 (37 infertil e and 14 fertil e men)	Male infertility	IL-6 TNF-alpha	Show abstract
24329571	Male infer tility, pr ostatitis and prosta to-vesicul itis			211 (169 infert ile patients (7 4 chronic bacte rial prostatiti s, 95 bilateral prostato-vesic ulitis), 42 fer tile men)	Male infertility	TNF-? IL-6 IL-10	Show abstract
17430733	Male infer tility			148 asymptomati c males from su bfertile couple s	Male infertility	TNF-alpha IL-1beta	Show abstract
1601744	Sperm moti lity, Male infertili ty				Male infertility		Show abstract
19811461	Obstructed azoosperm ia, asthen ospermia			73 male partner s of an inferti le couple atten ding a regional andrology unit �	Male infertility	�IL-6 IL-8 IL-10 IL-11 IL-12 TNF-alpha and IFN-gamma	Show abstract
25081128	Varicocele , leucocyt ospermia			184 (74 varicoc ele (VC) patien ts, 70 leucocyt ospermia patien ts, 40 normospe rmic men as con trols)	Male infertility	LEP TNF-?	Show abstract
25032981	Unexplaine d infertil ity			50 (30 with imm une infertility , 20 controls)	Male infertility, Female infertility	IL-21 IL-12 and TNF?	Show abstract
11839394	Asthenozoo spermia, o ligozoospe rmia, leuk ocytosperm ia			86 (62 subjects in the normozo ospermic group, 24 subjects sh owing abnormal sperm parameter s (azoospermia, n=5; oligozoos permia, n=4; as thenozoospermia , n=15))	Male infertility	interleukin [IL]-1alpha IL-2 �IL-4 IL-6 IL-8 tumor necrosis factor-alpha [TNF-alpha] interferon-gamma granulocyte colony-stimulating factor [G-CSF] macrophage CFS [M-CSF]	Show abstract
17507040	Male infer tility, hy pergonadot ropic hypo gonadism	leucine-75-proline�apolipoprotein A-I		10 presenting w ith infertility , gynecomastia, decreased libi do, erectile dy sfunction	Male infertility		Show abstract
21933900	Azoospermi a, astheno zoospermia			457 (289 infert ile men (118 no n obstructive a zoospermia, 137 asthenozoosper mia, 34 oligosp ermia), 168 age -matched fertil e controls)	Male infertility	miR-146b-5p	Show abstract
23209346	Leukocytos permia, sp erm motili ty			37 (22 cases of leukocytosperm ia, 15 cases of normal males)	Male infertility	PAF TNF-?	Show abstract
8723440	Sperm moti lity, male infertili ty			22 (14 infertil e males, 8 heal thy control sub jects)	Male infertility	IL-1 IL-6 TNF alpha	Show abstract
12202945	Male infer tility			79 (24 fertile men, 55 inferti le men (23 vari cocele, 14 pati ents post varic ocelectomy (pos t-varicocele), 10 male accesso ry gland infect ion, 8 bilatera l testicular at rophy )	Male infertility	IL-6 TNF-alpha	Show abstract
11868623	Male infer tility			71 (66 subferti le subjects (22 patients with varicocele, 14 with infection of accessory ge nital glands, 4 varicocele plu s infection, 8 chronic epididy mitis, 5 post-r enal transplant ation status, 9 idiopathic oli goasthenoterato spermia, 1 cryp torchidism, 3 h	Male infertility	IL-1beta TNF-alpha	Show abstract
17327269	Teratozoos permia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)	Show abstract
21674046	Aberrant C pGs in Low Motility Sperm			18	Male infertility	GSE26881	Show abstract

Male Infertility knowledgebase

A repository with genes crucial for male fertility

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Gene Summary

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Male Infertility knowledgebase

A repository with genes crucial for male fertility

Search Result

Gene Summary

SNPs

Protein Summary

Gene ontology

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KEGG pathways Expand All | Collapse All

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PubMed references

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Diseases

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