• Gene id: 7112

Gene Summary

• Gene Symbol: TMPO   Gene   UCSC   Ensembl
• Aliases: CMD1T, LAP2, LEMD4, PRO0868, TP
• Gene name: thymopoietin
• Alternate names: thymopoietin, LEM domain containing 4, lamina-associated polypeptide 2,
• Gene location: 12q23.1 (98515572: 98550350)     Exons: 1     NC_000012.12
• Gene summary(Entrez): Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expre
• OMIM: 188380

Protein Summary

• Protein general information: P42166  
  • Name: Lamina associated polypeptide 2, isoform alpha (Thymopoietin isoform alpha) (TP alpha) (Thymopoietin related peptide isoform alpha) (TPRP isoform alpha) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]
  • Length: 694  
  • Mass: 75492
  • Tissue specificity: Expressed in many tissues. Most abundant in adult thymus and fetal liver.
• Sequence:

  MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSKGPPDFSSDEEREPTP
  VLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLR
  EQGTESRSSTPLPTISSSAENTRQNGSNDSDRYSDNEEGKKKEHKKVKSTRDIVPFSELGTTPSGGGFFQGISFP
  EISTRPPLGSTELQAAKKVHTSKGDLPREPLVATNLPGRGQLQKLASERNLFISCKSSHDRCLEKSSSSSSQPEH
  SAMLVSTAASPSLIKETTTGYYKDIVENICGREKSGIQPLCPERSHISDQSPLSSKRKALEESESSQLISPPLAQ
  AIRDYVNSLLVQGGVGSLPGTSNSMPPLDVENIQKRIDQSKFQETEFLSPPRKVPRLSEKSVEERDSGSFVAFQN
  IPGSELMSSFAKTVVSHSLTTLGLEVAKQSQHDKIDASELSFPFHESILKVIEEEWQQVDRQLPSLACKYPVSSR
  EATQILSVPKVDDEILGFISEATPLGGIQAASTESCNQQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA
  AQILSSDPSRTHQALGILSKTYDAASYICEAAFDEVKMAAHTMGNATVGRRYLWLKDCKINLASKNKLASTPFKG
  GTLFGGEVCKVIKKRGNKH

• Structural information:
  • Protein Domains: (5..4-)
    (/note="LEM-like-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00313,-ECO:0000255|PROSITE-ProRule:PRU00314)
    (109..15-)
    (/note="LEM-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00313"-)
  • Interpro: IPR021623  IPR013146  IPR011015  IPR003887  
  • Prosite: PS50954 PS50955
  • PDB: 1GJJ 1H9E 1H9F
  • PDBsum: 1GJJ 1H9E 1H9F
  • STRING: ENSP00000266732
• Other Databases: GeneCards:  TMPO  Malacards:  TMPO
• Protein general information: P42167  
  
  Name: Lamina associated polypeptide 2, isoforms beta/gamma (Thymopoietin, isoforms beta/gamma) (TP beta/gamma) (Thymopoietin related peptide isoforms beta/gamma) (TPRP isoforms beta/gamma) [Cleaved into: Thymopoietin (TP) (Splenin); Thymopentin (TP5)]
  
  Length: 454  Mass: 50670
  
  Tissue specificity: Expressed in many tissues. Most abundant in adult thymus and fetal liver.
• Sequence: MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSKGPPDFSSDEEREPTP
  VLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDLLDQLVKYGVNPGPIVGTTRKLYEKKLLKLR
  EQGTESRSSTPLPTISSSAENTRQNGSNDSDRYSDNEEDSKIELKLEKREPLKGRAKTPVTLKQRRVEHNQSYSQ
  AGITETEWTSGSSKGGPLQALTRESTRGSRRTPRKRVETSEHFRIDGPVISESTPIAETIMASSNESLVVNRVTG
  NFKHASPILPITEFSDIPRRAPKKPLTRAEVGEKTEERRVERDILKEMFPYEASTPTGISASCRRPIKGAAGRPL
  ELSDFRMEESFSSKYVPKYVPLADVKSEKTKKGRSIPVWIKILLFVVVAVFLFLVYQAMETNQVNPFSNFLHVDP
  RKSN
• Structural information:

  Protein Domains	(5..4-) (/note="LEM-like-) (/evidence="ECO:0000255|PROSITE-ProRule:PRU00313,-ECO:0000255|PROSITE-ProRule:PRU00314) (109..15-) (/note="LEM-) (/evidence="ECO:0000255|PROSITE-ProRule:PRU00313"-)
  Interpro:	IPR013146  IPR011015  IPR003887
  Prosite:	PS50954 PS50955
  DIP:	43686
  MINT:

• Other Databases: GeneCards:  TMPO  Malacards:  TMPO

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003677	DNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005694	chromosome	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0005521	lamin binding	TAS	molecular function
GO:0005634	nucleus	TAS	cellular component
GO:0005635	nuclear envelope	TAS	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0000785	chromatin	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006355	regulation of transcription, DNA-templated	IEA	biological process
GO:0005635	nuclear envelope	IEA	cellular component
GO:0045296	cadherin binding	HDA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005694	chromosome	IEA	cellular component

Diseases

Associated diseases	References
Dilated cardiomyopathy	KEGG:H00294
Dilated cardiomyopathy	KEGG:H00294
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R