• Gene id: 7100

Gene Summary

• Gene Symbol: TLR5   Gene   UCSC   Ensembl
• Aliases: MELIOS, SLE1, SLEB1, TIL3
• Gene name: toll like receptor 5
• Alternate names: toll-like receptor 5, systemic lupus erythematosus susceptibility 1, toll/interleukin-1 receptor-like protein 3,
• Gene location: 1q41 (223143280: 223108400)     Exons: 7     NC_000001.11
• Gene summary(Entrez): This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are express
• OMIM: 191525

Protein Summary

• Protein general information: O60602  
  • Name: Toll like receptor 5 (Toll/interleukin 1 receptor like protein 3)
  • Length: 858  
  • Mass: 97834
  • Tissue specificity: Highly expressed on the basolateral surface of intestinal epithelia (PubMed
• Sequence:

  MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLL
  ELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRL
  DLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRN
  MVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
  FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAII
  QDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHL
  QILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHL
  TALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
  IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQ
  RLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWN
  SRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDFQDV
  GWFLHKLSQQILKKEKEKKKDNNIPLQTVATIS

• Structural information:
  • Protein Domains: (579..63-)
    (/note="LRRCT-)
    (691..83-)
    (/note="TIR-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00204"-)
  • Interpro: IPR000483  IPR001611  IPR003591  IPR032675  IPR000157   IPR027176  IPR035897  
  • Prosite: PS51450 PS50104
  • PDB: 1P95 3J0A
  • PDBsum: 1P95 3J0A
  • STRING: ENSP00000440643
• Other Databases: GeneCards:  TLR5  Malacards:  TLR5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0038023	signaling receptor activity	IBA	molecular function
GO:0006954	inflammatory response	IBA	biological process
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0002224	toll-like receptor signaling pathway	IBA	biological process
GO:0001819	positive regulation of cytokine production	IEA	biological process
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IEA	biological process
GO:0007165	signal transduction	IEA	biological process
GO:0034146	toll-like receptor 5 signaling pathway	IEA	biological process
GO:0045087	innate immune response	IEA	biological process
GO:0050707	regulation of cytokine secretion	IEA	biological process
GO:0002224	toll-like receptor signaling pathway	IEA	biological process
GO:0004888	transmembrane signaling receptor activity	IEA	molecular function
GO:0006955	immune response	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0042742	defense response to bacterium	IEA	biological process
GO:0002376	immune system process	IEA	biological process
GO:0045087	innate immune response	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0006954	inflammatory response	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	biological process
GO:0034146	toll-like receptor 5 signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0032757	positive regulation of interleukin-8 production	IDA	biological process
GO:0034123	positive regulation of toll-like receptor signaling pathway	IDA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0005149	interleukin-1 receptor binding	IPI	molecular function
GO:0071260	cellular response to mechanical stimulus	IEP	biological process

KEGG pathways

Pathway id	Pathway name
hsa05131	Shigellosis
hsa05132	Salmonella infection
hsa05130	Pathogenic Escherichia coli infection
hsa04620	Toll-like receptor signaling pathway
hsa05134	Legionellosis
hsa05321	Inflammatory bowel disease

Diseases

Associated diseases	References
Systemic lupus erythematosus	KEGG:H00080
Systemic lupus erythematosus	KEGG:H00080
Legionnaires' disease	PMID:14623910
Cystic fibrosis	PMID:18684966
Cystic fibrosis	PMID:21068401
Chronic granulomatous disease	PMID:18155283
Ankylosing spondylitis	PMID:20952467
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq