• Gene id: 7031

Gene Summary

• Gene Symbol: TFF1   Gene   UCSC   Ensembl
• Aliases: BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2
• Gene name: trefoil factor 1
• Alternate names: trefoil factor 1, breast cancer estrogen-inducible protein, breast cancer estrogen-inducible sequence, gastrointestinal trefoil protein pS2, polypeptide P1.A, protein pS2,
• Gene location: 21q22.3 (42366534: 42362281)     Exons: 3     NC_000021.9
• Gene summary(Entrez): Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are
• OMIM: 606496

Protein Summary

• Protein general information: P04155  
  • Name: Trefoil factor 1 (Breast cancer estrogen inducible protein) (PNR 2) (Polypeptide P1.A) (hP1.A) (Protein pS2)
  • Length: 84  
  • Mass: 9150
  • Tissue specificity: Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual
• Sequence:

  MATMENKVICALVLVSMLALGTLAEAQTETCTVAPRERQNCGFPGVTPSQCANKGCCFDDTVRGVPWCFYPNTID
  VPPEEECEF

• Structural information:
  • Protein Domains: (29..7-)
    (/note="P-type-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00779"-)
  • Interpro: IPR017994  IPR017957  IPR000519  
  • Prosite: PS00025 PS51448
  • CDD: cd00111
  • PDB: 1HI7 1PS2 6V1D
  • PDBsum: 1HI7 1PS2 6V1D
  • STRING: ENSP00000291527
• Other Databases: GeneCards:  TFF1  Malacards:  TFF1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0030277	maintenance of gastrointestinal epithelium	IBA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0008083	growth factor activity	IEA	molecular function
GO:0005975	carbohydrate metabolic process	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005615	extracellular space	IEA	cellular component
GO:0030154	cell differentiation	IEA	biological process
GO:0008285	negative regulation of cell population proliferation	IEA	biological process
GO:0043434	response to peptide hormone	IEA	biological process
GO:0035902	response to immobilization stress	IEA	biological process
GO:0030277	maintenance of gastrointestinal epithelium	IEA	biological process
GO:0010039	response to iron ion	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04915	Estrogen signaling pathway
P06959	CCKR signaling map
P06959	CCKR signaling map

Diseases

Associated diseases	References
Ductal carcinoma in situ	PMID:15375487
Endometrial hyperplasia	PMID:9221798
Prostate cancer	PMID:10458410
Prostate cancer	PMID:16467092
urinary bladder cancer	PMID:18283638
Endometrial cancer	PMID:10835496
Ovarian cancer	PMID:17624412
Transitional cell carcinoma	PMID:7965392
Endometrial carcinoma	PMID:9221798
signet ring cell adenocarcinoma	PMID:18283638
Cervical adenocarcinoma	PMID:10727981
ovarian carcinoma	PMID:9066601
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881