Home
Search

Simple

Advanced

Syndromes

Chromosomal defects

Infertility phenotypes

Highthroughput dataset
Browse

Genes

Proteins

SNPs

References

GO

Diseases

Pathways

Tools

Orthologs

SNPs

Motif scan

STRING

CDART
BLAST

BLASTN

BLASTP
Analysis

Panther

Function

GO

Pathways

Diseases
  Help
Statistics
   About Us

Search Result


Gene id 6954
Gene Summary    Protein Summary    Gene ontology    Diseases    PubMed    

Gene Summary
Gene Symbol TCP11   Gene   UCSC   Ensembl
Aliases D6S230E, FPPR
Gene name t-complex 11
Alternate names T-complex protein 11 homolog, fertilization-promoting peptide receptor, t-complex 11 (a murine tcp homolog), t-complex 11 homolog, t-complex 11, testis-specific, testis secretory sperm-binding protein Li 222n,
Gene location 6p21.31 (35141409: 35118070)     Exons: 11     NC_000006.12
OMIM 186982

Protein Summary
Protein general information Q8WWU5  

Name: T complex protein 11 homolog

Length: 503  Mass: 56,141

Sequence MPDVKESVPPKYPGDSEGRSCKPETSGPPQEDKSGSEDPPPFLSVTGLTETVNEVSKLSNKIGMNCDYYMEEKVL
PPSSLEGKVKETVHNAFWDHLKEQLSATPPDFSCALELLKEIKEILLSLLLPRQNRLRIEIEEALDMDLLKQEAE
HGALKVLYLSKYVLNMMALLCAPVRDEAVQKLENITDPVWLLRGIFQVLGRMKMDMVNYTIQSLQPHLQEHSIQY
ERAKFQELLNKQPSLLNHTTKWLTQAAGDLTMSPPTCPDTSDSSSVAGPSPNEAANNPEPLSPTMVLCQGFLNLL
LWDLENEEFPETLLMDRTRLQELKSQLHQLTVMASVLLVASSFSGSVLFGSPQFVDKLKRITKSLLEDFHSRPEE
AILTVSEQVSQEIHQSLKNMGLVALSSDNTASLMGQLQNIAKKENCVCSVIDQRIHLFLKCCLVLGVQRSLLDLP
GGLTLIEAELAELGQKFVNLTHHNQQVFGPYYTEILKTLISPAQALETKVESV
Structural information
Interpro:  IPR008862  
STRING:   ENSP00000308708
Other Databases GeneCards:  TCP11  Malacards:  TCP11

Gene ontology

Expand All | Collapse All
GO accessionTerm nameEvidence codeGo category
GO:0007275 multicellular organism de
velopment
 TAS biological process
GO:0007283 spermatogenesis
 IEA biological process
GO:0016021 integral component of mem
brane
 IEA cellular component
GO:0030154 cell differentiation
 IEA biological process
GO:0007275 multicellular organism de
velopment
 IEA biological process
GO:0007275 multicellular organism de
velopment
 TAS biological process
GO:0007283 spermatogenesis
 IEA biological process
GO:0016020 membrane
 IEA cellular component
GO:0016020 membrane
 IEA cellular component
GO:0016021 integral component of mem
brane
 IEA cellular component
GO:0030154 cell differentiation
 IEA biological process
GO:0007275 multicellular organism de
velopment
 TAS biological process

Diseases

Expand All | Collapse All
Associated diseases References
Varicocele MIK: 25999357
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Hypospermatogenesis MIK: 28361989
Non obstructive azoospermia MIK: 24012201
Sertoli cell only syndrome MIK: 23869807
Spermatogenic defects MIK: 9322250
Teratozoospermia MIK: 17327269
Varicocele MIK: 25999357

PubMed references

Expand All | Collapse All
PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
25999357 Varicocele
27 (17 men diag
nosed with bila
teral varicocel
e, 10 proven fe
rtile men as he
althy controls)
 Male infertility
Show abstract
9322250 Plays an i
mportant r
ole in reg
ulation of
human, as
well as m
ouse, sper
m function

Male infertility
Show abstract
17327269 Teratozoos
permia
13 (5 controls,
8 cases)
 Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
24012201 Non obstru
ctive azoo
spermia
31 (4 controls,
27 cases)
 Male infertility GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
23869807 Non obstru
ctive azoo
spermia, S
ertoli cel
l only syn
drome
20 (4 controls,
16 cases)
 Male infertility GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract
28361989 Hyposperma
togenesis
6 (3 controls,
3 Klienfelter s
yndrome
 Male infertility Microarray
 Show abstract
31037746 Spermatoge
nic defect
s
16 (1 control,
15 cases)
 Male infertility GSE6023 analyzed using GEO2R
 Show abstract