• Gene id: 6908

Gene Summary

• Gene Symbol: TBP   Gene   UCSC   Ensembl
• Aliases: GTF2D, GTF2D1, HDL4, SCA17, TFIID
• Gene name: TATA-box binding protein
• Alternate names: TATA-box-binding protein, TATA sequence-binding protein, TATA-box binding protein N-terminal domain, TATA-box factor, transcription initiation factor TFIID TBP subunit,
• Gene location: 6q27 (170554332: 170572869)     Exons: 8     NC_000006.12
• Gene summary(Entrez): Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly,
• OMIM: 600075

KEGG pathways

Pathway id	Pathway name
hsa05203	Viral carcinogenesis
hsa05016	Huntington disease
hsa05166	Human T-cell leukemia virus 1 infection
hsa05165	Human papillomavirus infection

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Associated with male germ cell development	MIK: 8776734
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
8776734	Associated with male germ cell development				Male infertility
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray