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Gene id 6821
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol SUOX   Gene   UCSC   Ensembl
Gene name sulfite oxidase
Alternate names sulfite oxidase, mitochondrial,
Gene location 12q13.2 (117873817: 117710647)     Exons: 29     NC_000007.14
Gene summary(Entrez) Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxid
OMIM 606887

Protein Summary
Protein general information P51687  

Name: Sulfite oxidase, mitochondrial (EC 1.8.3.1)

Length: 545  Mass: 60283

Sequence MLLLHRAVVLRLQQACRLKSIPSRICIQACSTNDSFQPQRPSLTFSGDNSSTQGWRVMGTLLGLGAVLAYQDHRC
RAAQESTHIYTKEEVSSHTSPETGIWVTLGSEVFDVTEFVDLHPGGPSKLMLAAGGPLEPFWALYAVHNQSHVRE
LLAQYKIGELNPEDKVAPTVETSDPYADDPVRHPALKVNSQRPFNAEPPPELLTENYITPNPIFFTRNHLPVPNL
DPDTYRLHVVGAPGGQSLSLSLDDLHNFPRYEITVTLQCAGNRRSEMTQVKEVKGLEWRTGAISTARWAGARLCD
VLAQAGHQLCETEAHVCFEGLDSDPTGTAYGASIPLARAMDPEAEVLLAYEMNGQPLPRDHGFPVRVVVPGVVGA
RHVKWLGRVSVQPEESYSHWQRRDYKGFSPSVDWETVDFDSAPSIQELPVQSAITEPRDGETVESGEVTIKGYAW
SGGGRAVIRVDVSLDGGLTWQVAKLDGEEQRPRKAWAWRLWQLKAPVPAGQKELNIVCKAVDDGYNVQPDTVAPI
WNLRGVLSNAWHRVHVYVSP
Structural information
Protein Domains
 (82..16-)
heme-binding (/note="Cytochrome-b5)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00279"-)
Interpro:  IPR001199  IPR036400  IPR018506  IPR014756  IPR005066  
IPR008335  IPR000572  IPR036374  IPR022407  
Prosite:   PS00191 PS50255 PS00559

PDB:  		 1MJ4
PDBsum:   1MJ4
STRING:   ENSP00000377668
Other Databases GeneCards:  SUOX  Malacards:  SUOX

Gene ontology

Expand All | Collapse All
GO accessionTerm nameEvidence codeGo category
GO:0043546 molybdopterin cofactor bi
nding
 IBA molecular function
GO:0020037 heme binding
 IBA molecular function
GO:0008482 sulfite oxidase activity
 IBA molecular function
GO:0006790 sulfur compound metabolic
process
 IBA biological process
GO:0005739 mitochondrion
 IBA cellular component
GO:0020037 heme binding
 IEA molecular function
GO:0030151 molybdenum ion binding
 IEA molecular function
GO:0043546 molybdopterin cofactor bi
nding
 IEA molecular function
GO:0055114 oxidation-reduction proce
ss
 IEA biological process
GO:0016491 oxidoreductase activity
 IEA molecular function
GO:0046872 metal ion binding
 IEA molecular function
GO:0055114 oxidation-reduction proce
ss
 IEA biological process
GO:0005739 mitochondrion
 IEA cellular component
GO:0016491 oxidoreductase activity
 IEA molecular function
GO:0008482 sulfite oxidase activity
 TAS molecular function
GO:0008482 sulfite oxidase activity
 IEA molecular function
GO:0005759 mitochondrial matrix
 TAS cellular component
GO:0070221 sulfide oxidation, using
sulfide:quinone oxidoredu
ctase
 TAS biological process
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005758 mitochondrial intermembra
ne space
 IEA cellular component
GO:0006790 sulfur compound metabolic
process
 IEA biological process

KEGG pathways

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Pathway idPathway name
hsa01100Metabolic pathways
hsa00920Sulfur metabolism

Diseases

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Associated diseases References
Sulfite oxidase deficiency KEGG:H01237
Sulfite oxidase deficiency KEGG:H01237
inherited metabolic disorder PMID:12112661
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia
13 (5 controls,
8 cases)
 Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract