• Gene id: 6801

Gene Summary

• Gene Symbol: STRN   Gene   UCSC   Ensembl
• Aliases: PPP2R6A, SG2NA, STRN1
• Gene name: striatin
• Alternate names: striatin, protein phosphatase 2 regulatory subunit B'''alpha, striatin, calmodulin binding protein,
• Gene location: 2p22.2 (36966606: 36837697)     Exons: 2     NC_000002.12
• OMIM: 614765

Protein Summary

• Protein general information: O43815  
  • Name: Striatin
  • Length: 780  
  • Mass: 86132
  • Tissue specificity: Preferentially expressed in brain. {ECO
• Sequence:

  MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERA
  ELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQN
  SQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELT
  DSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNE
  SRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLANLRDVDELPSLQPSVG
  SPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALR
  KTWNPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMS
  SNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE
  VAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPT
  LPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKK
  FEESIHDVAFHPSKCYIASAGADALAKVFV

• Structural information:
  • Interpro: IPR020472  IPR013258  IPR015943  IPR001680  IPR019775   IPR017986  IPR036322  
  • Prosite: PS00678 PS50082 PS50294
  • STRING: ENSP00000263918
• Other Databases: GeneCards:  STRN  Malacards:  STRN

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005516	calmodulin binding	IBA	molecular function
GO:0030425	dendrite	IBA	cellular component
GO:0070016	armadillo repeat domain binding	IBA	molecular function
GO:0044877	protein-containing complex binding	IBA	molecular function
GO:0051721	protein phosphatase 2A binding	IBA	molecular function
GO:0005516	calmodulin binding	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0030054	cell junction	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0043197	dendritic spine	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0044877	protein-containing complex binding	IDA	molecular function
GO:0090443	FAR/SIN/STRIPAK complex	IDA	cellular component
GO:0005923	bicellular tight junction	IDA	cellular component
GO:0051721	protein phosphatase 2A binding	IDA	molecular function
GO:0070830	bicellular tight junction assembly	NAS	biological process
GO:0043197	dendritic spine	ISS	cellular component
GO:0014069	postsynaptic density	ISS	cellular component
GO:0016358	dendrite development	ISS	biological process
GO:0008285	negative regulation of cell population proliferation	IMP	biological process
GO:0007626	locomotory behavior	ISS	biological process
GO:0005516	calmodulin binding	NAS	molecular function
GO:0005516	calmodulin binding	ISS	molecular function
GO:0045211	postsynaptic membrane	ISS	cellular component
GO:0043025	neuronal cell body	ISS	cellular component
GO:0030331	estrogen receptor binding	IPI	molecular function
GO:0016020	membrane	ISS	cellular component
GO:0070016	armadillo repeat domain binding	IPI	molecular function
GO:0016055	Wnt signaling pathway	IMP	biological process
GO:0005516	calmodulin binding	NAS	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq