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Gene id |
6794 |
| Gene Summary Protein Summary KEGG pathways Diseases PubMed |
Gene Summary
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Gene Symbol |
STK11 Gene UCSC Ensembl |
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Aliases |
LKB1, PJS, hLKB1 |
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Gene name |
serine/threonine kinase 11 |
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Alternate names |
serine/threonine-protein kinase STK11, liver kinase B1, polarization-related protein LKB1, renal carcinoma antigen NY-REN-19, serine/threonine-protein kinase 11, serine/threonine-protein kinase LKB1, |
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Gene location |
19p13.3 (1205798: 1228434) Exons: 10 NC_000084.6
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Gene summary(Entrez) |
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by
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OMIM |
602216 |
Protein Summary
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| Associated diseases |
References |
| Cancer (pancreatic) | GAD: 15331174 |
| Cancer (lung) | GAD: 17384680 |
| Cancer (bladder) | GAD: 19692168 |
| Cancer (breast) | GAD: 20722467 |
| Adenocarcinoma | GAD: 20559149 |
| Peutz-Jeghers syndrome | KEGG: H00666 |
| Hyperandrogenism | GAD: 20357370 |
| Diabetes | GAD: 20682687 |
| Alzheimer's disease | GAD: 19141999 |
| Polycystic ovary syndrome (PCOS) | GAD: 18000088 |
| Has a crucial role in spermiogenesis and male fertility | MIK: 18774945 |
| Chronic obstructive pulmonary disease (COPD) | GAD: 19625176 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Cryptorchidism | MIK: 28606200 |
| Has a crucial role in spermiogenesis and male fertility | MIK: 18774945 |
| Regulating spermatid differentiation | MIK: 29022902 |
| Spermatogenic defects | MIK: 31037746 |
| Unexplained infertility | MIK: 25753583 |
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| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 18774945 |
Has a cruc
ial role i
n spermiog
enesis and
male fert
ility
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Male infertility |
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Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
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18
|
Male infertility |
GSE26881
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Show abstract |
| 28606200 |
Cryptorchi
dism
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Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
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Male infertility |
MeDIP-Seq
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Show abstract |
| 31037746 |
Spermatoge
nic defect
s
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16 (1 control,
15 cases)
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Male infertility |
GSE6023 analyzed using GEO2R
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Show abstract |
| 25753583 |
Unexplaine
d infertil
ity
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46 (17 fertile
men, 29 male pa
tients)
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Male infertility |
Microarray
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Show abstract |
| 29022902 |
Regulating
spermatid
different
iation
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Male infertility |
|
Show abstract |
|