• Gene id: 6768

Gene Summary

• Gene Symbol: ST14   Gene   UCSC   Ensembl
• Aliases: ARCI11, HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15, TMPRSS14
• Gene name: ST14 transmembrane serine protease matriptase
• Alternate names: suppressor of tumorigenicity 14 protein, membrane-type serine protease 1, prostamin, serine protease 14, serine protease TADG-15, suppression of tumorigenicity 14 (colon carcinoma), suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin), tumor a,
• Gene location: 11q24.3 (130159781: 130210361)     Exons: 19     NC_000011.10
• Gene summary(Entrez): The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has b

Protein Summary

• Protein general information: Q9Y5Y6  
  • Name: Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane type serine protease 1) (MT SP1) (Prostamin) (Serine protease 14) (Serine protease TADG 15) (Tumor associated differentially expressed gene 15 protein)
  • Length: 855  
  • Mass: 94770
• Sequence:

  MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAAVLIGLLLVLLGIGFL
  VWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKVKDALKLLYSGVPFLGPYHKESAVTAFSEGS
  VIAYYWSEFSIPQHLVEEAERVMAEERVVMLPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVEL
  MRFTTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
  YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNN
  QHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSS
  DPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSC
  PAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
  DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAF
  LGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGW
  GHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVS
  WGDGCAQRNKPGVYTRLPLFRDWIKENTGV

• Structural information:
  • Protein Domains: (86..20-)
    (/note="SEA-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00188-)
    (214..33-)
    (/note="CUB-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00059-)
    (340..44-)
    (/note="CUB-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00059-)
    (-)
  • Interpro: IPR000859  IPR036055  IPR023415  IPR002172  IPR009003   IPR017051  IPR000082  IPR036364  IPR035914  IPR001254  IPR018114  IPR033116  
  • Prosite: PS01180 PS01209 PS50068 PS50024 PS50240 PS00134 PS00135
  • CDD: cd00041 cd00112 cd00190
  • PDB: 1EAW 1EAX 2FMV 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V 4R0I 5LYO 6N4T
  • PDBsum: 1EAW 1EAX 2FMV 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V 4R0I 5LYO 6N4T
  • STRING: ENSP00000278742
• Other Databases: GeneCards:  ST14  Malacards:  ST14

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030216	keratinocyte differentiation	IBA	biological process
GO:0030216	keratinocyte differentiation	IMP	biological process
GO:0004252	serine-type endopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016787	hydrolase activity	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0008236	serine-type peptidase activity	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0008236	serine-type peptidase activity	TAS	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0006508	proteolysis	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0070268	cornification	TAS	biological process
GO:0019897	extrinsic component of plasma membrane	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0019897	extrinsic component of plasma membrane	IEA	cellular component
GO:0016323	basolateral plasma membrane	IEA	cellular component
GO:0006508	proteolysis	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0060672	epithelial cell morphogenesis involved in placental branching	IEA	biological process
GO:0008236	serine-type peptidase activity	IEA	molecular function
GO:0001843	neural tube closure	IEA	biological process
GO:0008236	serine-type peptidase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0006508	proteolysis	IDA	biological process
GO:0008236	serine-type peptidase activity	IDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05206	MicroRNAs in cancer

Diseases

Associated diseases	References
Autosomal recessive congenital ichthyosis	KEGG:H00734
Ichthyosis with hypotrichosis	KEGG:H00739
Autosomal recessive congenital ichthyosis	KEGG:H00734
Ichthyosis with hypotrichosis	KEGG:H00739
Ductal carcinoma in situ	PMID:17163404
Granulosa cell tumor	PMID:16439987
dysgerminoma	PMID:16439987
renal cell carcinoma	PMID:16501837
prostate carcinoma in situ	PMID:18813126
Cryptorchidism	MIK: 28606200
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray