• Gene id: 6738

Gene Summary

• Gene Symbol: RO60   Gene   UCSC   Ensembl
• Aliases: RORNP, SSA2, TROVE2
• Gene name: Ro60, Y RNA binding protein
• Alternate names: 60 kDa SS-A/Ro ribonucleoprotein, 60 kDa ribonucleoprotein Ro, Ro/SSA 60kDa, Sjogren syndrome antigen A2 (60kD, ribonucleoprotein autoantigen SS-A/Ro), TROVE domain family member 2, gastric cancer multi-drug resistance protein, ro60 autoantigen, sjoegren syndrom,
• Gene location: 1q31.2 (193059453: 193091776)     Exons: 12     NC_000001.11
• OMIM: 600063

Protein Summary

• Protein general information: P10155  
  • Name: 60 kDa SS A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (Ro60) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS A) (TROVE domain family member 2)
  • Length: 538  
  • Mass: 60671
• Sequence:

  MEESVNQMQPLNEKQIANSQDGYVWQVTDMNRLHRFLCFGSEGGTYYIKEQKLGLENAEALIRLIEDGRGCEVIQ
  EIKSFSQEGRTTKQEPMLFALAICSQCSDISTKQAAFKAVSEVCRIPTHLFTFIQFKKDLKESMKCGMWGRALRK
  AIADWYNEKGGMALALAVTKYKQRNGWSHKDLLRLSHLKPSSEGLAIVTKYITKGWKEVHELYKEKALSVETEKL
  LKYLEAVEKVKRTRDELEVIHLIEEHRLVREHLLTNHLKSKEVWKALLQEMPLTALLRNLGKMTANSVLEPGNSE
  VSLVCEKLCNEKLLKKARIHPFHILIALETYKTGHGLRGKLKWRPDEEILKALDAAFYKTFKTVEPTGKRFLLAV
  DVSASMNQRVLGSILNASTVAAAMCMVVTRTEKDSYVVAFSDEMVPCPVTTDMTLQQVLMAMSQIPAGGTDCSLP
  MIWAQKTNTPADVFIVFTDNETFAGGVHPAIALREYRKKMDIPAKLIVCGMTSNGFTIADPDDRGMLDMCGFDTG
  ALDVIRNFTLDMI

• Structural information:
  • Protein Domains: (16..36-)
    (/note="TROVE-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00343"-)
  • Interpro: IPR040322  IPR008858  IPR037214  IPR036465  
  • Prosite: PS50988
  • STRING: ENSP00000356416
• Other Databases: GeneCards:  RO60  Malacards:  RO60

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003723	RNA binding	IBA	molecular function
GO:1990904	ribonucleoprotein complex	IBA	cellular component
GO:0010468	regulation of gene expression	IDA	biological process
GO:0035457	cellular response to interferon-alpha	IDA	biological process
GO:0003723	RNA binding	IDA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0030030	cell projection organization	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0003723	RNA binding	TAS	molecular function
GO:0006383	transcription by RNA polymerase III	TAS	biological process
GO:1990904	ribonucleoprotein complex	TAS	cellular component
GO:1990904	ribonucleoprotein complex	IEA	cellular component
GO:0060271	cilium assembly	IEA	biological process
GO:0030620	U2 snRNA binding	IEA	molecular function
GO:0009411	response to UV	IEA	biological process
GO:0007224	smoothened signaling pathway	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0002520	immune system development	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:1990904	ribonucleoprotein complex	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa05322	Systemic lupus erythematosus

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)