• Gene id: 6731

Gene Summary

• Gene Symbol: SRP72   Gene   UCSC   Ensembl
• Aliases: BMFF, BMFS1, HEL103
• Gene name: signal recognition particle 72
• Alternate names: signal recognition particle subunit SRP72, epididymis luminal protein 103, signal recognition particle 72 kDa protein, signal recognition particle 72kD, signal recognition particle 72kDa,
• Gene location: 4q12 (56467616: 56503680)     Exons: 20     NC_000004.12
• Gene summary(Entrez): This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SR
• OMIM: 602122

Protein Summary

• Protein general information: O76094  
  • Name: Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein)
  • Length: 671  
  • Mass: 74606
• Sequence:

  MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVL
  ANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTN
  LSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAEL
  AIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSK
  KQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEI
  KLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSPAHLSLI
  REAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSA
  GATYIRKKGGKVTGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGK
  GTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAPATKKKQQQKKKKGGKGGW

• Structural information:
  • Interpro: IPR013699  IPR026270  IPR031545  IPR013026  IPR011990   IPR019734  
  • Prosite: PS50005 PS50293
  • PDB: 5M72 5M73 5WRV 5WRW
  • PDBsum: 5M72 5M73 5WRV 5WRW
  • STRING: ENSP00000342181
• Other Databases: GeneCards:  SRP72  Malacards:  SRP72

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	IBA	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	IBA	biological process
GO:0008312	7S RNA binding	IBA	molecular function
GO:0043022	ribosome binding	IBA	contributes to
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	IEA	biological process
GO:0008312	7S RNA binding	IEA	molecular function
GO:0048500	signal recognition particle	IEA	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0008312	7S RNA binding	IMP	molecular function
GO:0043022	ribosome binding	IMP	contributes to
GO:0030911	TPR domain binding	IPI	molecular function
GO:0048500	signal recognition particle	IDA	cellular component
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	IDA	cellular component
GO:0042493	response to drug	IDA	biological process
GO:0005047	signal recognition particle binding	IPI	molecular function
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa03060	Protein export

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq