Male Infertility Database

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Gene id

6730

Gene Summary Protein Summary KEGG pathways Diseases PubMed

Gene Summary

Gene Symbol

SRP68 Gene UCSC Ensembl

Gene name

signal recognition particle 68

Alternate names

signal recognition particle subunit SRP68, signal recognition particle 68 kDa protein, signal recognition particle 68kD, signal recognition particle 68kDa,

Gene location

17q25.1 (76072525: 76038774) Exons: 17 NC_000017.11

Gene summary(Entrez)

This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits

OMIM

604858

Protein Summary

Protein general information

Q9UHB9

Name: Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein)

Length: 627 Mass: 70730

Sequence

MAAEKQVPGGGGGGGSGGGGGSGGGGSGGGRGAGGEENKENERPSAGSKANKEFGDSLSLEILQIIKESQQQHGL
RHGDFQRYRGYCSRRQRRLRKTLNFKMGNRHKFTGKKVTEELLTDNRYLLLVLMDAERAWSYAMQLKQEANTEPR
KRFHLLSRLRKAVKHAEELERLCESNRVDAKTKLEAQAYTAYLSGMLRFEHQEWKAAIEAFNKCKTIYEKLASAF
TEEQAVLYNQRVEEISPNIRYCAYNIGDQSAINELMQMRLRSGGTEGLLAEKLEALITQTRAKQAATMSEVEWRG
RTVPVKIDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDAIQVVREELKPDQKQRDYILEGEPGKVSN
LQYLHSYLTYIKLSTAIKRNENMAKGLQRALLQQQPEDDSKRSPRPQDLIRLYDIILQNLVELLQLPGLEEDKAF
QKEIGLKTLVFKAYRCFFIAQSYVLVKKWSEALVLYDRVLKYANEVNSDAGAFKNSLKDLPDVQELITQVRSEKC
SLQAAAILDANDAHQTETSSSQVKDNKPLVERFETFCLDPSLVTKQANLVHFPPGFQPIPCKPLFFDLALNHVAF
PPLEDKLEQKTKSGLTGYIKGIFGFRS

Structural information

Interpro:	IPR026258 IPR034652 IPR038253
CDD:	cd15481
PDB:	4P3E 4P3F 5M72 5M73 5WRV
PDBsum:	4P3E 4P3F 5M72 5M73 5WRV
DIP:	50905
MINT:
STRING:	ENSP00000312066

Other Databases

GeneCards: SRP68 Malacards: SRP68

KEGG pathways

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Pathway id	Pathway name
hsa03060	Protein export

Diseases

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Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

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PMID	Condition	Population details	Infertility_type	Associated_genes	Abstract
17327269	Teratozoos permia	13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)	Show abstract
21674046	Aberrant C pGs in Low Motility Sperm	18	Male infertility	GSE26881	Show abstract
28606200	Cryptorchi dism	Monozgotic twin s (1 control, I cwith cryptorc hidism)	Male infertility	MeDIP-Seq	Show abstract

Male Infertility knowledgebase

A repository with genes crucial for male fertility

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Male Infertility knowledgebase

A repository with genes crucial for male fertility

Search Result

Gene Summary

Protein Summary

KEGG pathways Expand All | Collapse All

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Diseases Expand All | Collapse All

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PubMed references

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KEGG pathways

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Diseases

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