• Gene id: 6698

Gene Summary

• Gene Symbol: SPRR1A   Gene   UCSC   Ensembl
• Aliases: SPRK
• Gene name: small proline rich protein 1A
• Alternate names: cornifin-A, 19 kDa pancornulin, SPR-IA, small proline-rich protein IA,
• Gene location: 1q21.3 (175478559: 175529741)     Exons: 11     NC_000005.10
• OMIM: 182265

Protein Summary

• Protein general information: P35321  
  • Name: Cornifin A (19 kDa pancornulin) (SPRK) (Small proline rich protein IA) (SPR IA)
  • Length: 89  
  • Mass: 9877
• Sequence:

  MNSQQQKQPCTPPPQPQQQQVKQPCQPPPQEPCIPKTKEPCHPKVPEPCHPKVPEPCQPKVPEPCQPKVPEPCPS
  TVTPAPAQQKTKQK

• Structural information:
  • Interpro: IPR003302  IPR026075  
  • STRING: ENSP00000357751
• Other Databases: GeneCards:  SPRR1A  Malacards:  SPRR1A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IEA	cellular component
GO:0018149	peptide cross-linking	IEA	biological process
GO:0031424	keratinization	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005198	structural molecule activity	TAS	molecular function
GO:0008544	epidermis development	TAS	biological process
GO:0001533	cornified envelope	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0070268	cornification	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0001533	cornified envelope	IDA	cellular component
GO:0030280	structural constituent of skin epidermis	IDA	molecular function
GO:0018149	peptide cross-linking	IDA	biological process
GO:0030216	keratinocyte differentiation	IDA	biological process
GO:0001533	cornified envelope	IDA	cellular component
GO:0018149	peptide cross-linking	IDA	biological process
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R