• Gene id: 6678

Gene Summary

• Gene Symbol: SPARC   Gene   UCSC   Ensembl
• Aliases: BM-40, OI17, ON, ONT
• Gene name: secreted protein acidic and cysteine rich
• Alternate names: SPARC, basement-membrane protein 40, secreted protein, acidic, cysteine-rich (osteonectin),
• Gene location: 5q33.1 (151686914: 151661095)     Exons: 10     NC_000005.10
• Gene summary(Entrez): This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene produc
• OMIM: 182120

Protein Summary

Gene ontology

GO accession	Term name	Evidence code	Go category

Diseases

Associated diseases	References
Scleroderma	GAD: 12428242
Osteoporosis	GAD: 18084690
Polycystic ovary syndrome (PCOS)	INFBASE: 22904171
Endometriosis	INFBASE: 19200988
Gingival overgrowth	GAD: 17970686
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Plays a regulatory role in fetal testis development	MIK: 16425238
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
16425238	Plays a regulatory role in fetal testis development				Male infertility
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881