• Gene id: 6665

Gene Summary

• Gene Symbol: SOX15   Gene   UCSC   Ensembl
• Aliases: SOX20, SOX26, SOX27
• Gene name: SRY-box transcription factor 15
• Alternate names: protein SOX-15, SRY (sex determining region Y)-box 15, SRY (sex determining region Y)-box 20, SRY-box 15,
• Gene location: 17p13.1 (7590093: 7588177)     Exons: 2     NC_000017.11
• Gene summary(Entrez): This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after for
• OMIM: 611915

Protein Summary

• Protein general information: O60248  
  • Name: Protein SOX 15 (Protein SOX 12) (Protein SOX 20)
  • Length: 233  
  • Mass: 25251
  • Tissue specificity: Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis. {ECO
• Sequence:

  MALPGSSQDQAWSLEPPAATAAASSSSGPQEREGAGSPAAPGTLPLEKVKRPMNAFMVWSSAQRRQMAQQNPKMH
  NSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRPRRKAKSSGAGPSRCGQGRGNLASGGPLWGP
  GYATTQPSRGFGYRPPSYSTAYLPGSYGSSHCKLEAPSPCSLPQSDPRLQGELLPTYTHYLPPGSPTPYNPPLAG
  APMPLTHL

• Structural information:
  • Interpro: IPR009071  IPR036910  IPR031269  
  • Prosite: PS50118
  • STRING: ENSP00000355354
• Other Databases: GeneCards:  SOX15  Malacards:  SOX15

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000790	nuclear chromatin	ISA	cellular component
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISM	molecular function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA	molecular function
GO:0030154	cell differentiation	IBA	biological process
GO:0009653	anatomical structure morphogenesis	IBA	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	biological process
GO:0006355	regulation of transcription, DNA-templated	IBA	biological process
GO:0005667	transcription regulator complex	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	molecular function
GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	biological process
GO:0003677	DNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0008584	male gonad development	TAS	biological process
GO:0006357	regulation of transcription by RNA polymerase II	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:2000288	positive regulation of myoblast proliferation	IEA	biological process
GO:0060707	trophoblast giant cell differentiation	IEA	biological process
GO:0048627	myoblast development	IEA	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IEA	biological process
GO:0045843	negative regulation of striated muscle tissue development	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA	molecular function
GO:0000122	negative regulation of transcription by RNA polymerase II	IEA	biological process
GO:0070318	positive regulation of G0 to G1 transition	IEA	biological process
GO:0043403	skeletal muscle tissue regeneration	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration	IEA	biological process
GO:0003682	chromatin binding	IEA	molecular function
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA	molecular function
GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration	ISS	biological process
GO:0030154	cell differentiation	ISS	biological process
GO:0070318	positive regulation of G0 to G1 transition	ISS	biological process
GO:0000122	negative regulation of transcription by RNA polymerase II	ISS	biological process
GO:0045843	negative regulation of striated muscle tissue development	ISS	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	ISS	biological process
GO:0048627	myoblast development	ISS	biological process
GO:2000288	positive regulation of myoblast proliferation	ISS	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0006355	regulation of transcription, DNA-templated	NAS	biological process
GO:0005634	nucleus	NAS	cellular component
GO:0003677	DNA binding	NAS	molecular function
GO:0006325	chromatin organization	NAS	biological process
GO:0003700	DNA-binding transcription factor activity	NAS	molecular function
GO:0060707	trophoblast giant cell differentiation	ISS	biological process
GO:0000790	nuclear chromatin	ISA	cellular component
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISM	molecular function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA	molecular function
GO:0030154	cell differentiation	IBA	biological process
GO:0009653	anatomical structure morphogenesis	IBA	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	biological process
GO:0006355	regulation of transcription, DNA-templated	IBA	biological process
GO:0005667	transcription regulator complex	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	molecular function
GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	biological process
GO:0003677	DNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0008584	male gonad development	TAS	biological process
GO:0006357	regulation of transcription by RNA polymerase II	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:2000288	positive regulation of myoblast proliferation	IEA	biological process
GO:0060707	trophoblast giant cell differentiation	IEA	biological process
GO:0048627	myoblast development	IEA	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IEA	biological process
GO:0045843	negative regulation of striated muscle tissue development	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA	molecular function
GO:0000122	negative regulation of transcription by RNA polymerase II	IEA	biological process
GO:0070318	positive regulation of G0 to G1 transition	IEA	biological process
GO:0043403	skeletal muscle tissue regeneration	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration	IEA	biological process
GO:0003682	chromatin binding	IEA	molecular function
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA	molecular function
GO:0014718	positive regulation of satellite cell activation involved in skeletal muscle regeneration	ISS	biological process
GO:0030154	cell differentiation	ISS	biological process
GO:0070318	positive regulation of G0 to G1 transition	ISS	biological process
GO:0000122	negative regulation of transcription by RNA polymerase II	ISS	biological process
GO:0045843	negative regulation of striated muscle tissue development	ISS	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	ISS	biological process
GO:0048627	myoblast development	ISS	biological process
GO:2000288	positive regulation of myoblast proliferation	ISS	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0006355	regulation of transcription, DNA-templated	NAS	biological process
GO:0005634	nucleus	NAS	cellular component
GO:0003677	DNA binding	NAS	molecular function
GO:0006325	chromatin organization	NAS	biological process
GO:0003700	DNA-binding transcription factor activity	NAS	molecular function
GO:0060707	trophoblast giant cell differentiation	ISS	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq