• Gene id: 6647

Gene Summary

• Gene Symbol: SOD1   Gene   UCSC   Ensembl
• Aliases: ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer
• Gene name: superoxide dismutase 1
• Alternate names: superoxide dismutase [Cu-Zn], Cu/Zn superoxide dismutase, SOD, soluble, epididymis secretory protein Li 44, indophenoloxidase A, superoxide dismutase 1, soluble, superoxide dismutase, cystolic,
• Gene location: 21q22.11 (31659621: 31668930)     Exons: 5     NC_000021.9
• Gene summary(Entrez): The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuri
• OMIM: 147450

Protein Summary

• Protein general information: P00441  
  • Name: Superoxide dismutase [Cu Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1)
  • Length: 154  
  • Mass: 15,936
• Sequence:

  MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGP
  KDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVI
  GIAQ

• Structural information:
  • Interpro: IPR036423  IPR024134  IPR018152  IPR001424  
  • Prosite: PS00087 PS00332
  • CDD: cd00305
  • PDB: 1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2MP3 2NAM 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ
  • PDBsum: 1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2MP3 2NAM 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ
  • DIP: 44941
  • STRING: ENSP00000270142
• Other Databases: GeneCards:  SOD1  Malacards:  SOD1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000187	activation of MAPK activity	ISS	biological process
GO:0000302	response to reactive oxygen species	TAS	biological process
GO:0000303	response to superoxide	IDA	biological process
GO:0001541	ovarian follicle development	ISS	biological process
GO:0001819	positive regulation of cytokine production	IDA	biological process
GO:0001890	placenta development	NAS	biological process
GO:0001895	retina homeostasis	ISS	biological process
GO:0001975	response to amphetamine	IEA	biological process
GO:0002262	myeloid cell homeostasis	ISS	biological process
GO:0002576	platelet degranulation	TAS	biological process
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	EXP	molecular function
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	TAS	molecular function
GO:0005507	copper ion binding	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005758	mitochondrial intermembrane space	TAS	cellular component
GO:0005759	mitochondrial matrix	NAS	cellular component
GO:0005764	lysosome	IEA	cellular component
GO:0005777	peroxisome	ISS	cellular component
GO:0005777	peroxisome	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006749	glutathione metabolic process	ISS	biological process
GO:0006801	superoxide metabolic process	ISS	biological process
GO:0006801	superoxide metabolic process	IDA	biological process
GO:0006879	cellular iron ion homeostasis	ISS	biological process
GO:0007283	spermatogenesis	ISS	biological process
GO:0007566	embryo implantation	ISS	biological process
GO:0007566	embryo implantation	NAS	biological process
GO:0007569	cell aging	IMP	biological process
GO:0007605	sensory perception of sound	ISS	biological process
GO:0007626	locomotory behavior	ISS	biological process
GO:0008089	anterograde axonal transport	ISS	biological process
GO:0008090	retrograde axonal transport	ISS	biological process
GO:0008217	regulation of blood pressure	ISS	biological process
GO:0008270	zinc ion binding	IDA	molecular function
GO:0009408	response to heat	ISS	biological process
GO:0010033	response to organic substance	IDA	biological process
GO:0019226	transmission of nerve impulse	ISS	biological process
GO:0019430	removal of superoxide radicals	ISS	biological process
GO:0019430	removal of superoxide radicals	IC	biological process
GO:0030346	protein phosphatase 2B binding	IDA	molecular function
GO:0031012	extracellular matrix	IDA	cellular component
GO:0031045	dense core granule	IEA	cellular component
GO:0031410	cytoplasmic vesicle	IDA	cellular component
GO:0031667	response to nutrient levels	IEA	biological process
GO:0032287	peripheral nervous system myelin maintenance	ISS	biological process
GO:0032839	dendrite cytoplasm	IDA	cellular component
GO:0032930	positive regulation of superoxide anion generation	IDA	biological process
GO:0033081	regulation of T cell differentiation in thymus	NAS	biological process
GO:0034465	response to carbon monoxide	IEA	biological process
GO:0035865	cellular response to potassium ion	IEA	biological process
GO:0040014	regulation of multicellular organism growth	ISS	biological process
GO:0042493	response to drug	ISS	biological process
GO:0042542	response to hydrogen peroxide	ISS	biological process
GO:0042554	superoxide anion generation	IEA	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042803	protein homodimerization activity	NAS	molecular function
GO:0042803	protein homodimerization activity	NAS	molecular function
GO:0043025	neuronal cell body	IDA	cellular component
GO:0043065	positive regulation of apoptotic process	IC	biological process
GO:0043085	positive regulation of catalytic activity	IDA	biological process
GO:0043087	regulation of GTPase activity	IDA	biological process
GO:0043209	myelin sheath	IEA	cellular component
GO:0043234	protein complex	IDA	cellular component
GO:0043524	negative regulation of neuron apoptotic process	ISS	biological process
GO:0045471	response to ethanol	ISS	biological process
GO:0045541	negative regulation of cholesterol biosynthetic process	IDA	biological process
GO:0045859	regulation of protein kinase activity	IDA	biological process
GO:0046620	regulation of organ growth	NAS	biological process
GO:0046677	response to antibiotic	IEA	biological process
GO:0046688	response to copper ion	IEA	biological process
GO:0046716	muscle cell cellular homeostasis	ISS	biological process
GO:0048365	Rac GTPase binding	IDA	molecular function
GO:0048538	thymus development	NAS	biological process
GO:0048678	response to axon injury	ISS	biological process
GO:0050665	hydrogen peroxide biosynthetic process	ISS	biological process
GO:0050665	hydrogen peroxide biosynthetic process	IDA	biological process
GO:0051087	chaperone binding	IPI	molecular function
GO:0051881	regulation of mitochondrial membrane potential	IMP	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0060047	heart contraction	IDA	biological process
GO:0060052	neurofilament cytoskeleton organization	ISS	biological process
GO:0060087	relaxation of vascular smooth muscle	ISS	biological process
GO:0060088	auditory receptor cell stereocilium organization	ISS	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0071276	cellular response to cadmium ion	IEA	biological process
GO:0071318	cellular response to ATP	IEA	biological process
GO:0072593	reactive oxygen species metabolic process	IDA	biological process
GO:0097332	response to antipsychotic drug	IEA	biological process
GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP	biological process
GO:1904115	axon cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0000187	activation of MAPK activity	IEA	biological process
GO:0000187	activation of MAPK activity	ISS	biological process
GO:0000302	response to reactive oxygen species	IEA	biological process
GO:0000302	response to reactive oxygen species	TAS	biological process
GO:0000303	response to superoxide	IEA	biological process
GO:0000303	response to superoxide	IDA	biological process
GO:0001541	ovarian follicle development	IEA	biological process
GO:0001541	ovarian follicle development	ISS	biological process
GO:0001819	positive regulation of cytokine production	IDA	biological process
GO:0001890	placenta development	NAS	biological process
GO:0001895	retina homeostasis	IEA	biological process
GO:0001895	retina homeostasis	ISS	biological process
GO:0001975	response to amphetamine	IEA	biological process
GO:0002262	myeloid cell homeostasis	IEA	biological process
GO:0002262	myeloid cell homeostasis	ISS	biological process
GO:0002576	platelet degranulation	TAS	biological process
GO:0004784	superoxide dismutase activity	IEA	molecular function
GO:0004784	superoxide dismutase activity	IEA	molecular function
GO:0004784	superoxide dismutase activity	IEA	molecular function
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	EXP	molecular function
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	TAS	molecular function
GO:0005507	copper ion binding	IEA	molecular function
GO:0005507	copper ion binding	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005758	mitochondrial intermembrane space	IEA	cellular component
GO:0005758	mitochondrial intermembrane space	TAS	cellular component
GO:0005759	mitochondrial matrix	NAS	cellular component
GO:0005764	lysosome	IEA	cellular component
GO:0005777	peroxisome	IEA	cellular component
GO:0005777	peroxisome	ISS	cellular component
GO:0005777	peroxisome	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006749	glutathione metabolic process	IEA	biological process
GO:0006749	glutathione metabolic process	ISS	biological process
GO:0006801	superoxide metabolic process	IEA	biological process
GO:0006801	superoxide metabolic process	IEA	biological process
GO:0006801	superoxide metabolic process	ISS	biological process
GO:0006801	superoxide metabolic process	IDA	biological process
GO:0006879	cellular iron ion homeostasis	IEA	biological process
GO:0006879	cellular iron ion homeostasis	ISS	biological process
GO:0006979	response to oxidative stress	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0007283	spermatogenesis	ISS	biological process
GO:0007566	embryo implantation	IEA	biological process
GO:0007566	embryo implantation	ISS	biological process
GO:0007566	embryo implantation	NAS	biological process
GO:0007568	aging	IEA	biological process
GO:0007569	cell aging	IMP	biological process
GO:0007605	sensory perception of sound	IEA	biological process
GO:0007605	sensory perception of sound	ISS	biological process
GO:0007626	locomotory behavior	IEA	biological process
GO:0007626	locomotory behavior	ISS	biological process
GO:0008089	anterograde axonal transport	IEA	biological process
GO:0008089	anterograde axonal transport	ISS	biological process
GO:0008090	retrograde axonal transport	IEA	biological process
GO:0008090	retrograde axonal transport	ISS	biological process
GO:0008217	regulation of blood pressure	IEA	biological process
GO:0008217	regulation of blood pressure	ISS	biological process
GO:0008270	zinc ion binding	IDA	molecular function
GO:0009408	response to heat	IEA	biological process
GO:0009408	response to heat	ISS	biological process
GO:0010033	response to organic substance	IDA	biological process
GO:0016209	antioxidant activity	IEA	molecular function
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0019226	transmission of nerve impulse	IEA	biological process
GO:0019226	transmission of nerve impulse	ISS	biological process
GO:0019430	removal of superoxide radicals	IEA	biological process
GO:0019430	removal of superoxide radicals	ISS	biological process
GO:0019430	removal of superoxide radicals	IC	biological process
GO:0019899	enzyme binding	IEA	molecular function
GO:0030141	secretory granule	IEA	cellular component
GO:0030346	protein phosphatase 2B binding	IEA	molecular function
GO:0030346	protein phosphatase 2B binding	IDA	molecular function
GO:0031012	extracellular matrix	IDA	cellular component
GO:0031045	dense core granule	IEA	cellular component
GO:0031410	cytoplasmic vesicle	IDA	cellular component
GO:0031667	response to nutrient levels	IEA	biological process
GO:0032287	peripheral nervous system myelin maintenance	IEA	biological process
GO:0032287	peripheral nervous system myelin maintenance	ISS	biological process
GO:0032839	dendrite cytoplasm	IDA	cellular component
GO:0032930	positive regulation of superoxide anion generation	IDA	biological process
GO:0033081	regulation of T cell differentiation in thymus	NAS	biological process
GO:0034465	response to carbon monoxide	IEA	biological process
GO:0034599	cellular response to oxidative stress	IEA	biological process
GO:0035865	cellular response to potassium ion	IEA	biological process
GO:0040014	regulation of multicellular organism growth	IEA	biological process
GO:0040014	regulation of multicellular organism growth	ISS	biological process
GO:0042493	response to drug	IEA	biological process
GO:0042493	response to drug	ISS	biological process
GO:0042542	response to hydrogen peroxide	IEA	biological process
GO:0042542	response to hydrogen peroxide	ISS	biological process
GO:0042554	superoxide anion generation	IEA	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042803	protein homodimerization activity	NAS	molecular function
GO:0042803	protein homodimerization activity	NAS	molecular function
GO:0043005	neuron projection	IEA	cellular component
GO:0043025	neuronal cell body	IEA	cellular component
GO:0043025	neuronal cell body	IDA	cellular component
GO:0043065	positive regulation of apoptotic process	IC	biological process
GO:0043066	negative regulation of apoptotic process	IEA	biological process
GO:0043085	positive regulation of catalytic activity	IEA	biological process
GO:0043085	positive regulation of catalytic activity	IDA	biological process
GO:0043087	regulation of GTPase activity	IDA	biological process
GO:0043209	myelin sheath	IEA	cellular component
GO:0043234	protein complex	IEA	cellular component
GO:0043234	protein complex	IDA	cellular component
GO:0043524	negative regulation of neuron apoptotic process	IEA	biological process
GO:0043524	negative regulation of neuron apoptotic process	ISS	biological process
GO:0045471	response to ethanol	ISS	biological process
GO:0045541	negative regulation of cholesterol biosynthetic process	IDA	biological process
GO:0045859	regulation of protein kinase activity	IDA	biological process
GO:0046620	regulation of organ growth	NAS	biological process
GO:0046677	response to antibiotic	IEA	biological process
GO:0046688	response to copper ion	IEA	biological process
GO:0046716	muscle cell cellular homeostasis	IEA	biological process
GO:0046716	muscle cell cellular homeostasis	ISS	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0048365	Rac GTPase binding	IDA	molecular function
GO:0048538	thymus development	NAS	biological process
GO:0048678	response to axon injury	IEA	biological process
GO:0050665	hydrogen peroxide biosynthetic process	IEA	biological process
GO:0050665	hydrogen peroxide biosynthetic process	ISS	biological process
GO:0050665	hydrogen peroxide biosynthetic process	IDA	biological process
GO:0051087	chaperone binding	IPI	molecular function
GO:0051881	regulation of mitochondrial membrane potential	IMP	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0060047	heart contraction	IEA	biological process
GO:0060047	heart contraction	IDA	biological process
GO:0060052	neurofilament cytoskeleton organization	IEA	biological process
GO:0060052	neurofilament cytoskeleton organization	ISS	biological process
GO:0060087	relaxation of vascular smooth muscle	IEA	biological process
GO:0060087	relaxation of vascular smooth muscle	ISS	biological process
GO:0060088	auditory receptor cell stereocilium organization	IEA	biological process
GO:0060088	auditory receptor cell stereocilium organization	ISS	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0071276	cellular response to cadmium ion	IEA	biological process
GO:0071318	cellular response to ATP	IEA	biological process
GO:0072593	reactive oxygen species metabolic process	IDA	biological process
GO:0097332	response to antipsychotic drug	IEA	biological process
GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP	biological process
GO:1904115	axon cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0000187	activation of MAPK activity	ISS	biological process
GO:0000302	response to reactive oxygen species	TAS	biological process
GO:0000303	response to superoxide	IDA	biological process
GO:0001541	ovarian follicle development	ISS	biological process
GO:0001819	positive regulation of cytokine production	IDA	biological process
GO:0001890	placenta development	NAS	biological process
GO:0001895	retina homeostasis	ISS	biological process
GO:0002262	myeloid cell homeostasis	ISS	biological process
GO:0002576	platelet degranulation	TAS	biological process
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	EXP	molecular function
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	IDA	molecular function
GO:0004784	superoxide dismutase activity	TAS	molecular function
GO:0005507	copper ion binding	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005758	mitochondrial intermembrane space	TAS	cellular component
GO:0005759	mitochondrial matrix	NAS	cellular component
GO:0005777	peroxisome	ISS	cellular component
GO:0005777	peroxisome	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006749	glutathione metabolic process	ISS	biological process
GO:0006801	superoxide metabolic process	ISS	biological process
GO:0006801	superoxide metabolic process	IDA	biological process
GO:0006879	cellular iron ion homeostasis	ISS	biological process
GO:0007283	spermatogenesis	ISS	biological process
GO:0007566	embryo implantation	ISS	biological process
GO:0007566	embryo implantation	NAS	biological process
GO:0007569	cell aging	IMP	biological process
GO:0007605	sensory perception of sound	ISS	biological process
GO:0007626	locomotory behavior	ISS	biological process
GO:0008089	anterograde axonal transport	ISS	biological process
GO:0008090	retrograde axonal transport	ISS	biological process
GO:0008217	regulation of blood pressure	ISS	biological process
GO:0008270	zinc ion binding	IDA	molecular function
GO:0009408	response to heat	ISS	biological process
GO:0010033	response to organic substance	IDA	biological process
GO:0019226	transmission of nerve impulse	ISS	biological process
GO:0019430	removal of superoxide radicals	ISS	biological process
GO:0019430	removal of superoxide radicals	IC	biological process
GO:0030346	protein phosphatase 2B binding	IDA	molecular function
GO:0031012	extracellular matrix	IDA	cellular component
GO:0031410	cytoplasmic vesicle	IDA	cellular component
GO:0032287	peripheral nervous system myelin maintenance	ISS	biological process
GO:0032839	dendrite cytoplasm	IDA	cellular component
GO:0032930	positive regulation of superoxide anion generation	IDA	biological process
GO:0033081	regulation of T cell differentiation in thymus	NAS	biological process
GO:0040014	regulation of multicellular organism growth	ISS	biological process
GO:0042493	response to drug	ISS	biological process
GO:0042542	response to hydrogen peroxide	ISS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042803	protein homodimerization activity	NAS	molecular function
GO:0042803	protein homodimerization activity	NAS	molecular function
GO:0043025	neuronal cell body	IDA	cellular component
GO:0043065	positive regulation of apoptotic process	IC	biological process
GO:0043085	positive regulation of catalytic activity	IDA	biological process
GO:0043087	regulation of GTPase activity	IDA	biological process
GO:0043234	protein complex	IDA	cellular component
GO:0043524	negative regulation of neuron apoptotic process	ISS	biological process
GO:0045471	response to ethanol	ISS	biological process
GO:0045541	negative regulation of cholesterol biosynthetic process	IDA	biological process
GO:0045859	regulation of protein kinase activity	IDA	biological process
GO:0046620	regulation of organ growth	NAS	biological process
GO:0046716	muscle cell cellular homeostasis	ISS	biological process
GO:0048365	Rac GTPase binding	IDA	molecular function
GO:0048538	thymus development	NAS	biological process
GO:0048678	response to axon injury	ISS	biological process
GO:0050665	hydrogen peroxide biosynthetic process	ISS	biological process
GO:0050665	hydrogen peroxide biosynthetic process	IDA	biological process
GO:0051087	chaperone binding	IPI	molecular function
GO:0051881	regulation of mitochondrial membrane potential	IMP	biological process
GO:0060047	heart contraction	IDA	biological process
GO:0060052	neurofilament cytoskeleton organization	ISS	biological process
GO:0060087	relaxation of vascular smooth muscle	ISS	biological process
GO:0060088	auditory receptor cell stereocilium organization	ISS	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0072593	reactive oxygen species metabolic process	IDA	biological process
GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04146	Peroxisome
hsa04213	Longevity regulating pathway - multiple species
hsa05014	Amyotrophic lateral sclerosis
hsa05016	Huntington disease
hsa05020	Prion diseases

Diseases

Associated diseases	References
Cancer	GAD: 17646272
Cancer (bladder)	GAD: 19692168
Cancer (brain)	GAD: 19505917
Cancer (glioblastoma)	GAD: 19423540
Cancer (lung)	GAD: 18676680
Cancer (lymphoma)	GAD: 18636124
Cancer (meningeal)	GAD: 20406964
Cancer (prostate)	GAD: 18582155
Cancer (breast)	GAD: 16424062
Atherosclerosis	GAD: 20485444
Multiple sclerosis	GAD: 18563468
Diabetes	GAD: 12732844
Hypercholesterolemia	GAD: 20602615
Familial amyotrophic lateral sclerosis	GAD: 8446170
Amyotrophic lateral sclerosis (ALS)	GAD: 15623718
Alzheimer's disease	GAD: 16036425
Preeclampsia	GAD: 18387669
Adenomyosis	INFBASE: 8372889
Age dependent ultrastructural modifications in human granulosa cells	INFBASE: 17005595
Endometriosis	INFBASE: 25947891
Female infertility	INFBASE: 23330125
Infertility	INFBASE: 24444339
Polycystic ovary syndrome (PCOS)	INFBASE: 24526356
Oligoasthenoteratospermia	MIK: 8671428
Oligoasthenoteratozoospermia	MIK: 17540046
Asthenozoospermia	MIK: 17540046
Varicocele	MIK: 18294306
Asthenoteratozoospermia	MIK: 17540046
Oligoasthenozoospermia	MIK: 19517995
Sperm fertilization capacity	MIK: 24658925
Semen quality	MIK: 18292819
Sperm function	MIK: 20684956
Sperm motility	MIK: 22154371
Leukocytospermia	MIK: 7789553
Oligozoospermia	MIK: 18294306
Varicocele	MIK: 22086312
Oligozoospermia	MIK: 1847045
Male factor infertility	MIK: 24444339
Oligoteratospermia	MIK: 8671428
Varicocele	MIK: 18264794
Unexplained infertility	MIK: 11002563
Polyzoospermia	MIK: 14579418
Azoospermia	MIK: 18294306
Chronic obstructive pulmonary disease (COPD)	GAD: 19705749
Albuminuria	GAD: 17914031
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Asthenoteratozoospermia	MIK: 17540046
Oligoasthenoteratozoospermia	MIK: 17540046
Asthenozoospermia	MIK: 22211112
Polyzoospermia	MIK: 14579418
Azoospermia	MIK: 18294306
Oligozoospermia	MIK: 18294306
Varicocele	MIK: 18294306
Hypospermatogenesis	MIK: 28361989
Male infertility	MIK: 24444339
Leukocytospermia	MIK: 7789553
Male infertility	MIK: 11968048
Semen quality	MIK: 18292819
Sperm fertilization potential	MIK: 24658925
Sperm function	MIK: 20684956
Sperm motility	MIK: 22154371

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24658925	Male infertility, sperm fertilization potential	rs4880		435 male infertility patients	Male infertility	SOD
24444339	Idiopathic infertility, Male infertility	rs4880, rs1799983		110 infertile subjects (58 women and 52 men) with a history of idiopathic infertility, 69 fertile subjects (35 women and 34 men)	Male infertility	MnSOD MPO GPx1 CAT eNOS
26568756	Male infertility			66 (25 fertile men, 41 infertile men)	Male infertility	SOD MDA PHP and 8-OHdG
24082556	Male infertility		Northea st Indi a	70 (50 infertile individuals, 20 fertile donors)	Male infertility
22211112	Asthenozoospermia, oligoasthenoteratozoospermia		Tunisia n	115 (40 controls, 45 asthenozoospermics, 35 oligoasthenoteratozoospermics)	Male infertility
22154371	Sperm motility, Male infertility			42 normozoospermic patients consulting for infertility	Male infertility
22086312	Male infertility, varicocele			60 (48 varicocele patients, 12 non-varicocele inguinal hernia patients)	Male infertility
20684956	Male infertility, sperm function				Male infertility
19517995	Idiopathic oligoasthenozoospermic			63 (33 infertile oligo-asthenozoospermic (OA) men, 30 fertile controls)	Male infertility
19288454	Male infertility			102 (9 normozoospermic, 13 azoospermic, 38 oligoasthenozoospermic, 42 asthenozoospermic )	Male infertility	CAT SOD
18292819	Male infertility, semen quality			15 (10 patients consulting for infertility, 5 healthy sperm donors as controls)	Male infertility
18294306	Azoospermia, Oligospermia, Varicocele			88 (28 azoospermic, 30 oligospermic (15 with varicocele and 15 without) and 30 patients with normal semen characteristics (15 with varicocele and 15 without))	Male infertility
18264794	Varicocele, Male infertility			25 (15 primary infertile varicocele patients, ten normal-nonvaricocele-fertile control)	Male infertility
18264794	Varicocele, Male infertility			25 (15 primary infertile varicocele patients, ten normal-nonvaricocele-fertile control)	Male infertility
17540046	Asthenozoospermia, asthenoteratozoospermia and oligoasthenoteratozoospermia			46 (15 asthenozoospermic, 16 asthenoteratozoospermic, 15 oligoasthenoteratozoospermic)	Male infertility
16130269	Male infertility			133 (40 normozoospermic individuals, 93 infertile males)	Male infertility
11968048	Male infertility			51 (20 normospermia, 31 oligoasthenozoospermia)	Male infertility
9730437	Male infertility, leukocytospermia				Male infertility
8671428	Oligospermic, oligoasthenoteratospermia, oligoteratospermic			73 (10 healthy, fertile volunteers and 63 infertile males)	Male infertility
21443057	Male infertility			77 infertile and fertile healthy individuals	Male infertility	SOD CAT
16683572	Male infertility			80 (40 infertile patients with positive AsAb in seminal plasma as experimental group, 40 fertile men as control group)	Male infertility	NOS SOD
26198800	Male infertility			218 (85 fertile, 133 patients treated for infertility)	Male infertility	SOD catalase
14579418	Asthenozoospermic, polyzoospermic				Male infertility	SOD
1847045	Oligospermia				Male infertility	SOD
7789553	Leukocytospermia				Male infertility	Elastase SOD IL2 IL-8
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray