• Gene id: 6624

Gene Summary

• Gene Symbol: FSCN1   Gene   UCSC   Ensembl
• Aliases: FAN1, HSN, SNL, p55
• Gene name: fascin actin-bundling protein 1
• Alternate names: fascin, 55 kDa actin-bundling protein, epididymis secretory sperm binding protein, fascin homolog 1, actin-bundling protein, singed-like (fascin homolog, sea urchin),
• Gene location: 7p22.1 (5592815: 5606654)     Exons: 5     NC_000007.14
• Gene summary(Entrez): This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell mi
• OMIM: 182285

Protein Summary

• Protein general information: Q16658  
  • Name: Fascin (55 kDa actin bundling protein) (Singed like protein) (p55)
  • Length: 493  
  • Mass: 54530
  • Tissue specificity: Ubiquitous.
• Sequence:

  MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKD
  GNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRK
  RYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRD
  CEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDR
  DTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSEL
  FLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVD
  FFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY

• Structural information:
  • Interpro: IPR008999  IPR010431  IPR022768  IPR024703  IPR030146  
  • CDD: cd00257
  • PDB: 1DFC 3LLP 3P53 4GOV 4GOY 4GP0 4GP3 6B0T 6I0Z 6I10 6I11 6I12 6I13 6I14 6I15 6I16 6I17 6I18
  • PDBsum: 1DFC 3LLP 3P53 4GOV 4GOY 4GP0 4GP3 6B0T 6I0Z 6I10 6I11 6I12 6I13 6I14 6I15 6I16 6I17 6I18
  • DIP: 33171
  • STRING: ENSP00000371798
• Other Databases: GeneCards:  FSCN1  Malacards:  FSCN1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051015	actin filament binding	IBA	molecular function
GO:0031253	cell projection membrane	IBA	cellular component
GO:0030175	filopodium	IBA	cellular component
GO:0016477	cell migration	IBA	biological process
GO:0015629	actin cytoskeleton	IBA	cellular component
GO:0005902	microvillus	IBA	cellular component
GO:0001726	ruffle	IBA	cellular component
GO:0051017	actin filament bundle assembly	IBA	biological process
GO:0030426	growth cone	IBA	cellular component
GO:0030027	lamellipodium	IBA	cellular component
GO:0007163	establishment or maintenance of cell polarity	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0003779	actin binding	IDA	molecular function
GO:0090091	positive regulation of extracellular matrix disassembly	IDA	biological process
GO:0030175	filopodium	IDA	cellular component
GO:0044393	microspike	IDA	cellular component
GO:0002102	podosome	IDA	cellular component
GO:0071803	positive regulation of podosome assembly	IDA	biological process
GO:0001726	ruffle	IDA	cellular component
GO:0044393	microspike	IDA	cellular component
GO:0051017	actin filament bundle assembly	IDA	biological process
GO:0008144	drug binding	IDA	molecular function
GO:0032956	regulation of actin cytoskeleton organization	IDA	biological process
GO:0051491	positive regulation of filopodium assembly	IDA	biological process
GO:0051015	actin filament binding	IDA	molecular function
GO:0030046	parallel actin filament bundle assembly	IDA	biological process
GO:0051491	positive regulation of filopodium assembly	IDA	biological process
GO:0032534	regulation of microvillus assembly	IDA	biological process
GO:0044393	microspike	IDA	cellular component
GO:0005902	microvillus	IDA	cellular component
GO:0030035	microspike assembly	IDA	biological process
GO:0005911	cell-cell junction	IDA	cellular component
GO:0031253	cell projection membrane	IDA	cellular component
GO:0035089	establishment of apical/basal cell polarity	IDA	biological process
GO:0010592	positive regulation of lamellipodium assembly	IDA	biological process
GO:0007043	cell-cell junction assembly	IDA	biological process
GO:0005856	cytoskeleton	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0016477	cell migration	IMP	biological process
GO:0030035	microspike assembly	IMP	biological process
GO:0051491	positive regulation of filopodium assembly	IMP	biological process
GO:0030426	growth cone	ISS	cellular component
GO:0030027	lamellipodium	ISS	cellular component
GO:0007015	actin filament organization	IEA	biological process
GO:0016477	cell migration	IEA	biological process
GO:0030036	actin cytoskeleton organization	IEA	biological process
GO:0051015	actin filament binding	IEA	molecular function
GO:0030674	protein-macromolecule adaptor activity	IEA	molecular function
GO:0003779	actin binding	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0030054	cell junction	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0051017	actin filament bundle assembly	TAS	biological process
GO:0015629	actin cytoskeleton	TAS	cellular component
GO:0030036	actin cytoskeleton organization	TAS	biological process
GO:0051015	actin filament binding	IDA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0019221	cytokine-mediated signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003779	actin binding	IEA	molecular function
GO:0016477	cell migration	IEA	biological process
GO:0030175	filopodium	IEA	cellular component
GO:0051015	actin filament binding	IEA	molecular function
GO:0051491	positive regulation of filopodium assembly	IEA	biological process
GO:0008144	drug binding	IEA	molecular function
GO:0030027	lamellipodium	IEA	cellular component
GO:0030426	growth cone	IEA	cellular component
GO:0051017	actin filament bundle assembly	IEA	biological process
GO:0045296	cadherin binding	HDA	molecular function
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005902	microvillus	IEA	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0005938	cell cortex	IEA	cellular component
GO:0030054	cell junction	IEA	cellular component
GO:0030175	filopodium	IEA	cellular component
GO:0071437	invadopodium	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0030175	filopodium	IDA	cellular component
GO:0030036	actin cytoskeleton organization	IDA	biological process
GO:0071437	invadopodium	IDA	cellular component
GO:0051015	actin filament binding	IDA	molecular function
GO:0048870	cell motility	IDA	biological process
GO:0015629	actin cytoskeleton	IDA	cellular component
GO:0003779	actin binding	IDA	molecular function
GO:0001725	stress fiber	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0003723	RNA binding	HDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05206	MicroRNAs in cancer

Diseases

Associated diseases	References
pancreatic cancer	PMID:17696949
pancreatic ductal carcinoma	PMID:12109856
common bile duct neoplasm	PMID:15136764
cholangiocarcinoma	PMID:19721413
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq