• Gene id: 6616

Gene Summary

• Gene Symbol: SNAP25   Gene   UCSC   Ensembl
• Aliases: CMS18, RIC-4, RIC4, SEC9, SNAP, SNAP-25, SUP, bA416N4.2, dJ1068F16.2
• Gene name: synaptosome associated protein 25
• Alternate names: synaptosomal-associated protein 25, resistance to inhibitors of cholinesterase 4 homolog, synaptosomal-associated protein, 25kDa, synaptosome associated protein 25kDa,
• Gene location: 20p12.2 (10218829: 10307419)     Exons: 7     NC_000020.11
• Gene summary(Entrez): Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE comple
• OMIM: 600322

Protein Summary

• Protein general information: P60880  
  • Name: Synaptosomal associated protein 25 (SNAP 25) (Super protein) (SUP) (Synaptosomal associated 25 kDa protein)
  • Length: 206  
  • Mass: 23315
  • Tissue specificity: Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.
• Sequence:

  MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAE
  KNLTDLGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENL
  EQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG

• Structural information:
  • Protein Domains: (19..8-)
    homology (/note="t-SNARE-coiled-coil)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00202-)
    (140..20-)
    homology (/note="t-SNARE-coiled-coil)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00202"-)
  • Interpro: IPR039077  IPR000928  IPR000727  
  • Prosite: PS50192
  • PDB: 1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J
  • PDBsum: 1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J
  • DIP: 34554
  • STRING: ENSP00000254976
• Other Databases: GeneCards:  SNAP25  Malacards:  SNAP25

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005856	cytoskeleton	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0042734	presynaptic membrane	TAS	cellular component
GO:0031201	SNARE complex	TAS	cellular component
GO:0016079	synaptic vesicle exocytosis	TAS	biological process
GO:0048306	calcium-dependent protein binding	ISS	molecular function
GO:0031201	SNARE complex	ISS	cellular component
GO:0043005	neuron projection	ISS	cellular component
GO:0030426	growth cone	ISS	cellular component
GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	IBA	cellular component
GO:0031201	SNARE complex	IBA	cellular component
GO:0017075	syntaxin-1 binding	IBA	molecular function
GO:0016082	synaptic vesicle priming	IBA	biological process
GO:0006906	vesicle fusion	IBA	biological process
GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	IBA	biological process
GO:0019905	syntaxin binding	IBA	molecular function
GO:0006887	exocytosis	IBA	biological process
GO:0005886	plasma membrane	IBA	cellular component
GO:0005484	SNAP receptor activity	IBA	molecular function
GO:0031083	BLOC-1 complex	IDA	colocalizes with
GO:0016020	membrane	ISS	cellular component
GO:0005737	cytoplasm	ISS	cellular component
GO:0008076	voltage-gated potassium channel complex	ISS	colocalizes with
GO:0005515	protein binding	IPI	molecular function
GO:0017075	syntaxin-1 binding	IEA	molecular function
GO:0000149	SNARE binding	IEA	molecular function
GO:0005249	voltage-gated potassium channel activity	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0043005	neuron projection	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0035579	specific granule membrane	TAS	cellular component
GO:0043312	neutrophil degranulation	TAS	biological process
GO:0070821	tertiary granule membrane	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0007269	neurotransmitter secretion	TAS	biological process
GO:0014047	glutamate secretion	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005802	trans-Golgi network	IEA	cellular component
GO:0007269	neurotransmitter secretion	IEA	biological process
GO:0007626	locomotory behavior	IEA	biological process
GO:0008021	synaptic vesicle	IEA	cellular component
GO:0010975	regulation of neuron projection development	IEA	biological process
GO:0016079	synaptic vesicle exocytosis	IEA	biological process
GO:0017075	syntaxin-1 binding	IEA	molecular function
GO:0030424	axon	IEA	cellular component
GO:0036477	somatodendritic compartment	IEA	cellular component
GO:0042734	presynaptic membrane	IEA	cellular component
GO:0043005	neuron projection	IEA	cellular component
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0060291	long-term synaptic potentiation	IEA	biological process
GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	IEA	cellular component
GO:0098794	postsynapse	IEA	cellular component
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0000149	SNARE binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0008306	associative learning	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0070201	regulation of establishment of protein localization	IEA	biological process
GO:0098967	exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IEA	biological process
GO:0099590	neurotransmitter receptor internalization	IEA	biological process
GO:0043005	neuron projection	IEA	cellular component
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0001917	photoreceptor inner segment	IEA	cellular component
GO:0071805	potassium ion transmembrane transport	IEA	biological process
GO:0031201	SNARE complex	IDA	cellular component
GO:0031201	SNARE complex	IDA	cellular component
GO:0031982	vesicle	IDA	colocalizes with
GO:0050796	regulation of insulin secretion	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0001504	neurotransmitter uptake	NAS	biological process
GO:0016081	synaptic vesicle docking	NAS	biological process
GO:0007268	chemical synaptic transmission	NAS	biological process
GO:0017075	syntaxin-1 binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04721	Synaptic vesicle cycle
hsa04911	Insulin secretion

Diseases

Associated diseases	References
Congenital myasthenic syndrome	KEGG:H00770
Congenital myasthenic syndrome	KEGG:H00770
Down syndrome	PMID:12499044
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq