• Gene id: 6586

Gene Summary

• Gene Symbol: SLIT3   Gene   UCSC   Ensembl
• Aliases: MEGF5, SLIL2, SLIT1, Slit-3, slit2
• Gene name: slit guidance ligand 3
• Alternate names: slit homolog 3 protein, multiple EGF-like domains protein 5, multiple epidermal growth factor-like domains protein 5, slit homolog 3,
• Gene location: 5q34-q35.1 (169301138: 168661739)     Exons: 37     NC_000005.10
• Gene summary(Entrez): The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Protein Summary

• Protein general information: O75094  
  • Name: Slit homolog 3 protein (Slit 3) (Multiple epidermal growth factor like domains protein 5) (Multiple EGF like domains protein 5)
  • Length: 1523  
  • Mass: 167713
  • Tissue specificity: Predominantly expressed in thyroid. {ECO
• Sequence:

  MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITR
  ITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPR
  KAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAW
  LSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLME
  IPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIVKGLF
  DGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLAD
  YLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVR
  IPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRV
  FRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLG
  KWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGM
  PKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSL
  RVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT
  HRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDS
  HKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAK
  CIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQ
  YECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGD
  NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINS
  PLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDS
  VVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHIS
  DQGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQ
  CTDGSSFVEEVERHLECGCLACS

• Structural information:
  • Protein Domains: (34..6-)
    (/note="LRRNT-)
    (215..26-)
    (/note="LRRCT-1)
    (271..30-)
    (/note="LRRNT-2)
    (437..48-)
    (/note="LRRCT-2)
    (496..53-)
    (/note="LRRNT-3)
    (663..71-)
    (/note="LRRCT-3)
    (716..75-)
    (/note="LRRNT-4)
    (857..90-)
  • Interpro: IPR013320  IPR000483  IPR006207  IPR001881  IPR013032   IPR000742  IPR000152  IPR018097  IPR009030  IPR001791  IPR001611  IPR003591  IPR032675  IPR000372  
  • Prosite: PS01185 PS01225 PS00022 PS01186 PS50026 PS01187 PS50025 PS51450
  • STRING: ENSP00000332164
• Other Databases: GeneCards:  SLIT3  Malacards:  SLIT3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0050919	negative chemotaxis	IBA	biological process
GO:0048495	Roundabout binding	IBA	molecular function
GO:0008201	heparin binding	IBA	molecular function
GO:0007411	axon guidance	IBA	biological process
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0030154	cell differentiation	IEA	biological process
GO:0007399	nervous system development	IEA	biological process
GO:0007275	multicellular organism development	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0008285	negative regulation of cell population proliferation	IEA	biological process
GO:0009887	animal organ morphogenesis	IEA	biological process
GO:0003180	aortic valve morphogenesis	IEA	biological process
GO:0003181	atrioventricular valve morphogenesis	IEA	biological process
GO:0007411	axon guidance	IEA	biological process
GO:0010629	negative regulation of gene expression	IEA	biological process
GO:0060412	ventricular septum morphogenesis	IEA	biological process
GO:0003180	aortic valve morphogenesis	ISS	biological process
GO:0003181	atrioventricular valve morphogenesis	ISS	biological process
GO:0060412	ventricular septum morphogenesis	ISS	biological process
GO:0030308	negative regulation of cell growth	IMP	biological process
GO:0035385	Roundabout signaling pathway	IMP	biological process
GO:0070100	negative regulation of chemokine-mediated signaling pathway	IMP	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0048846	axon extension involved in axon guidance	IDA	biological process
GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration	IDA	NOT|biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0050919	negative chemotaxis	IDA	biological process
GO:0007411	axon guidance	IDA	biological process
GO:0051414	response to cortisol	IEP	biological process
GO:0005509	calcium ion binding	NAS	molecular function
GO:0048495	Roundabout binding	IPI	molecular function
GO:0061364	apoptotic process involved in luteolysis	IEP	biological process
GO:0048495	Roundabout binding	IPI	molecular function
GO:0032870	cellular response to hormone stimulus	IEP	biological process
GO:0005739	mitochondrion	NAS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04360	Axon guidance

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray