• Gene id: 653275

Gene Summary

• Gene Symbol: CFC1B   Gene   UCSC   Ensembl
• Gene name: cripto, FRL-1, cryptic family 1B
• Alternate names: cryptic family protein 1B,
• Gene location: 2q21.1 (130521211: 130528602)     Exons: 6     NC_000002.12
• OMIM: 0

Protein Summary

• Protein general information: P0CG36  
  • Name: Cryptic family protein 1B
  • Length: 223  
  • Mass: 24642
• Sequence:

  MTWRHHVRLLFTVSLALQIINLGNSYQREKHNGGREEVTKVATQKHRQSPLNWTSSHFGEVTGSAEGWGPEEPLP
  YSWAFGEGASARPRCCRNGGTCVLGSFCVCPAHFTGRYCEHDQRRSECGALEHGAWTLRACHLCRCIFGALHCLP
  LQTPDRCDPKDFLASHAHGPSAGGAPSLLLLLPCALLHRLLRPDAPAHPRSLVPSVLQRERRPCGRPGLGHRL

• Structural information:
  • Protein Domains: (86..11-)
    (/note="EGF-like-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00076"-)
  • Interpro: IPR019011  IPR013032  IPR000742  
  • Prosite: PS00022 PS50026
  • STRING: ENSP00000281882
• Other Databases: GeneCards:  CFC1B  Malacards:  CFC1B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0038100	nodal binding	IBA	molecular function
GO:0038092	nodal signaling pathway	IBA	biological process
GO:0009952	anterior/posterior pattern specification	IBA	biological process
GO:0005576	extracellular region	IBA	cellular component
GO:0070697	activin receptor binding	IBA	molecular function
GO:0048856	anatomical structure development	IBA	biological process
GO:0009986	cell surface	IBA	cellular component
GO:0007507	heart development	IBA	biological process
GO:0007368	determination of left/right symmetry	IBA	biological process
GO:0005102	signaling receptor binding	IBA	molecular function
GO:0001568	blood vessel development	IBA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0007275	multicellular organism development	IEA	biological process
GO:0007369	gastrulation	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)