• Gene id: 65220

Gene Summary

• Gene Symbol: NADK   Gene   UCSC   Ensembl
• Aliases: dJ283E3.1
• Gene name: NAD kinase
• Alternate names: NAD kinase, poly(P)/ATP NAD kinase,
• Gene location: 1p36.33 (1780508: 1751231)     Exons: 19     NC_000001.11
• Gene summary(Entrez): NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]
• OMIM: 611616

Protein Summary

• Protein general information: O95544  
  • Name: NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase)
  • Length: 446  
  • Mass: 49228
  • Tissue specificity: Widely expressed but not detected in skeletal muscle. {ECO
• Sequence:

  MEMEQEKMTMNKELSPDAAAYCCSACHGDETWSYNHPIRGRAKSRSLSASPALGSTKEFRRTRSLHGPCPVTTFG
  PKACVLQNPQTIMHIQDPASQRLTWNKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAIAS
  DESFGAVKKKFCTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVT
  QVIEGNAAVVLRSRLKVRVVKELRGKKTAVHNGLGENGSQAAGLDMDVGKQAMQYQVLNEVVIDRGPSSYLSNVD
  VYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEAR
  NTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDPVSDWFESLAQCLHWNVRKKQAHFEEEEEEEEEG

• Structural information:
  • Interpro: IPR017438  IPR017437  IPR016064  IPR002504  
  • PDB: 3PFN
  • PDBsum: 3PFN
  • STRING: ENSP00000367890
• Other Databases: GeneCards:  NADK  Malacards:  NADK

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003951	NAD+ kinase activity	IBA	molecular function
GO:0006741	NADP biosynthetic process	IBA	biological process
GO:0003951	NAD+ kinase activity	IEA	molecular function
GO:0019674	NAD metabolic process	IEA	biological process
GO:0006741	NADP biosynthetic process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0003951	NAD+ kinase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0019674	NAD metabolic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA	biological process
GO:0006741	NADP biosynthetic process	IEA	biological process
GO:0003951	NAD+ kinase activity	IDA	molecular function
GO:0046034	ATP metabolic process	NAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0016310	phosphorylation	NAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00760	Nicotinate and nicotinamide metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq