• Gene id: 6522

Gene Summary

• Gene Symbol: SLC4A2   Gene   UCSC   Ensembl
• Aliases: AE2, BND3L, EPB3L1, HKB3, NBND3
• Gene name: solute carrier family 4 member 2
• Alternate names: anion exchange protein 2, anion exchanger 2 type a, anion exchanger 2 type b1, anion exchanger 2 type b2, erythrocyte membrane protein band 3-like 1, non-erythroid band 3-like protein, solute carrier family 4 (anion exchanger), member 2,
• Gene location: 7q36.1 (151058199: 151076526)     Exons: 25     NC_000007.14
• Gene summary(Entrez): This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary bil

Protein Summary

• Protein general information: P04920  
  • Name: Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non erythroid band 3 like protein) (BND3L) (Solute carrier family 4 member 2)
  • Length: 1241  
  • Mass: 137009
• Sequence:

  MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHR
  QSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPS
  SVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPK
  AQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSG
  REGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLE
  LRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFPRNISAGSLGSL
  LGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVE
  FLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLT
  AINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPL
  RRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQ
  GVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQE
  IFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNT
  ALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEK
  RGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFG
  LPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYM
  GVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLR
  MVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV

• Structural information:
  • Interpro: IPR001717  IPR002978  IPR018241  IPR013769  IPR011531   IPR003020  IPR016152  
  • Prosite: PS00219 PS00220
  • STRING: ENSP00000419412
• Other Databases: GeneCards:  SLC4A2  Malacards:  SLC4A2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0015701	bicarbonate transport	IBA	biological process
GO:0051453	regulation of intracellular pH	IBA	biological process
GO:0005452	inorganic anion exchanger activity	IEA	molecular function
GO:0006820	anion transport	IEA	biological process
GO:0008509	anion transmembrane transporter activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0015297	antiporter activity	IEA	molecular function
GO:0015301	anion:anion antiporter activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0006811	ion transport	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0008509	anion transmembrane transporter activity	TAS	molecular function
GO:0016020	membrane	TAS	cellular component
GO:0006820	anion transport	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0015701	bicarbonate transport	TAS	biological process
GO:0016323	basolateral plasma membrane	IEA	cellular component
GO:0007283	spermatogenesis	IEA	biological process
GO:0051453	regulation of intracellular pH	IEA	biological process
GO:0048565	digestive tract development	IEA	biological process
GO:0019899	enzyme binding	IEA	molecular function
GO:0016324	apical plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0098656	anion transmembrane transport	IEA	biological process
GO:0098656	anion transmembrane transport	IEA	biological process
GO:0098656	anion transmembrane transport	IEA	biological process
GO:0055085	transmembrane transport	IEA	biological process
GO:0015698	inorganic anion transport	IEA	biological process
GO:0005925	focal adhesion	HDA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0015701	bicarbonate transport	IBA	biological process
GO:0051453	regulation of intracellular pH	IBA	biological process
GO:0005452	inorganic anion exchanger activity	IEA	molecular function
GO:0006820	anion transport	IEA	biological process
GO:0008509	anion transmembrane transporter activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0015297	antiporter activity	IEA	molecular function
GO:0015301	anion:anion antiporter activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0006811	ion transport	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0008509	anion transmembrane transporter activity	TAS	molecular function
GO:0016020	membrane	TAS	cellular component
GO:0006820	anion transport	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0015701	bicarbonate transport	TAS	biological process
GO:0016323	basolateral plasma membrane	IEA	cellular component
GO:0007283	spermatogenesis	IEA	biological process
GO:0051453	regulation of intracellular pH	IEA	biological process
GO:0048565	digestive tract development	IEA	biological process
GO:0019899	enzyme binding	IEA	molecular function
GO:0016324	apical plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0098656	anion transmembrane transport	IEA	biological process
GO:0098656	anion transmembrane transport	IEA	biological process
GO:0098656	anion transmembrane transport	IEA	biological process
GO:0055085	transmembrane transport	IEA	biological process
GO:0015698	inorganic anion transport	IEA	biological process
GO:0005925	focal adhesion	HDA	cellular component
GO:0016020	membrane	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04972	Pancreatic secretion
hsa04970	Salivary secretion
hsa04971	Gastric acid secretion
hsa04976	Bile secretion

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq