• Gene id: 64979

Gene Summary

• Gene Symbol: MRPL36   Gene   UCSC   Ensembl
• Aliases: BRIP1, L36mt, MRP-L36, PRPL36, RPMJ
• Gene name: mitochondrial ribosomal protein L36
• Alternate names: 39S ribosomal protein L36, mitochondrial, BRCA1-interacting protein 1, mitochondrial large ribosomal subunit protein bL36m, putative BRCA1-interacting protein,
• Gene location: 5p15.33 (1801431: 1798384)     Exons: 5     NC_000005.10
• Gene summary(Entrez): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot
• OMIM: 611842

Protein Summary

• Protein general information: Q9P0J6  
  • Name: 39S ribosomal protein L36, mitochondrial (L36mt) (MRP L36) (BRCA1 interacting protein 1) (Mitochondrial large ribosomal subunit protein bL36m)
  • Length: 103  
  • Mass: 11784
• Sequence:

  MANLFIRKMVNPLLYLSRHTVKPRALSTFLFGSIRGAAPVAVEPGAAVRSLLSPGLLPHLLPALGFKNKTVLKKR
  CKDCYLVKRRGRWYVYCKTHPRHKQRQM

• Structural information:
  • Interpro: IPR000473  IPR035977  
  • PDB: 3J7Y 3J9M 5OOL 6NU2 6NU3
  • PDBsum: 3J7Y 3J9M 5OOL 6NU2 6NU3
  • STRING: ENSP00000423399
• Other Databases: GeneCards:  MRPL36  Malacards:  MRPL36

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042254	ribosome biogenesis	IBA	biological process
GO:0005762	mitochondrial large ribosomal subunit	IBA	cellular component
GO:0005762	mitochondrial large ribosomal subunit	IDA	cellular component
GO:0005840	ribosome	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0005840	ribosome	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0070125	mitochondrial translational elongation	TAS	biological process
GO:0070126	mitochondrial translational termination	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0016604	nuclear body	IDA	cellular component
GO:0005762	mitochondrial large ribosomal subunit	NAS	cellular component
GO:0006412	translation	NAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq