• Gene id: 64975

Gene Summary

• Gene Symbol: MRPL41   Gene   UCSC   Ensembl
• Aliases: BMRP, MRP-L27, MRPL27, PIG3, RPML27
• Gene name: mitochondrial ribosomal protein L41
• Alternate names: 39S ribosomal protein L41, mitochondrial, 39S ribosomal protein L27 homolog, L41mt, MRP-L27 homolog, MRP-L41, bcl-2-interacting mitochondrial ribosomal protein L41, cell proliferation-inducing gene 3 protein, mitochondrial large ribosomal subunit protein mL41, pr,
• Gene location: 9q34.3 (137551878: 137552554)     Exons: 3     NC_000009.12
• Gene summary(Entrez): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot
• OMIM: 611846

Protein Summary

• Protein general information: Q8IXM3  
  • Name: 39S ribosomal protein L41, mitochondrial (L41mt) (MRP L41) (39S ribosomal protein L27 homolog) (Bcl 2 interacting mitochondrial ribosomal protein L41) (Cell proliferation inducing gene 3 protein) (MRP L27 homolog) (Mitochondrial large ribosomal subunit pr
  • Length: 137  
  • Mass: 15383
  • Tissue specificity: Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level). {ECO
• Sequence:

  MGVLAAAARCLVRGADRMSKWTSKRGPRSFRGRKGRGAKGIGFLTSGWRFVQIKEMVPEFVVPDLTGFKLKPYVS
  YLAPESEETPLTAAQLFSEAVAPAIEKDFKDGTFDPDNLEKYGFEPTQEGKLFQLYPRNFLR

• Structural information:
  • Interpro: IPR019189  
  • PDB: 3J7Y 3J9M 5OOL 5OOM 6NU2 6NU3
  • PDBsum: 3J7Y 3J9M 5OOL 5OOM 6NU2 6NU3
  • STRING: ENSP00000360498
• Other Databases: GeneCards:  MRPL41  Malacards:  MRPL41

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006412	translation	IBA	biological process
GO:0005762	mitochondrial large ribosomal subunit	IBA	cellular component
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:0005762	mitochondrial large ribosomal subunit	IDA	cellular component
GO:0005762	mitochondrial large ribosomal subunit	IDA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005840	ribosome	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0007049	cell cycle	IEA	biological process
GO:0006915	apoptotic process	IEA	biological process
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0005743	mitochondrial inner membrane	TAS	cellular component
GO:0070125	mitochondrial translational elongation	TAS	biological process
GO:0070126	mitochondrial translational termination	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005762	mitochondrial large ribosomal subunit	IDA	cellular component
GO:0003735	structural constituent of ribosome	IDA	molecular function
GO:0006412	translation	IDA	biological process
GO:1990904	ribonucleoprotein complex	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)