• Gene id: 64900

Gene Summary

• Gene Symbol: LPIN3   Gene   UCSC   Ensembl
• Aliases: LIPN3L, SMP2, dJ620E11.2
• Gene name: lipin 3
• Alternate names: phosphatidate phosphatase LPIN3,
• Gene location: 20q12 (41340778: 41360582)     Exons: 23     NC_000020.11
• Gene summary(Entrez): The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family membe
• OMIM: 182309

Protein Summary

• Protein general information: Q9BQK8  
  • Name: Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin 3) (Lipin 3 like)
  • Length: 851  
  • Mass: 93614
  • Tissue specificity: Significant expression in intestine and other regions of the gastrointestinal tract. {ECO
• Sequence:

  MNYVGQLAETVFGTVKELYRGLNPATLSGGIDVLVVKQVDGSFRCSPFHVRFGKLGVLRSREKVVDIELNGEPVD
  LHMKLGDSGEAFFVQELESDDEHVPPGLCTSPIPWGGLSGFPSDSQLGTASEPEGLVMAGTASTGRRKRRRRRKP
  KQKEDAVATDSSPEELEAGAESELSLPEKLRPEPPGVQLEEKSSLQPKDIYPYSDGEWPPQASLSAGELTSPKSD
  SELEVRTPEPSPLRAESHMQWAWGRLPKVARAERPESSVVLEGRAGATSPPRGGPSTPSTSVAGGVDPLGLPIQQ
  TEAGADLQPDTEDPTLVGPPLHTPETEESKTQSSGDMGLPPASKSWSWATLEVPVPTGQPERVSRGKGSPKRSQH
  LGPSDIYLDDLPSLDSENAALYFPQSDSGLGARRWSEPSSQKSLRDPNPEHEPEPTLDTVDTIALSLCGGLADSR
  DISLEKFNQHSVSYQDLTKNPGLLDDPNLVVKINGKHYNWAVAAPMILSLQAFQKNLPKSTMDKLEREKMPRKGG
  RWWFSWRRRDFLAEERSAQKEKTAAKEQQGEKTEVLSSDDDAPDSPVILEIPSLPPSTPPSTPTYKKSLRLSSDQ
  IRRLNLQEGANDVVFSVTTQYQGTCRCKATIYLWKWDDKVVISDIDGTITKSDALGHILPQLGKDWTHQGITSLY
  HKIQLNGYKFLYCSARAIGMADLTKGYLQWVSEGGCSLPKGPILLSPSSLFSALHREVIEKKPEVFKVACLSDIQ
  QLFLPHGQPFYAAFGNRPNDVFAYRQVGLPESRIFTVNPRGELIQELIKNHKSTYERLGEVVELLFPPVARGPST
  DLANPEYSNFCYWREPLPAVDLDTLD

• Structural information:
  • Interpro: IPR036412  IPR026058  IPR031703  IPR007651  IPR013209   IPR031315  
  • STRING: ENSP00000362354
• Other Databases: GeneCards:  LPIN3  Malacards:  LPIN3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0032869	cellular response to insulin stimulus	IBA	biological process
GO:0009062	fatty acid catabolic process	IBA	biological process
GO:0008195	phosphatidate phosphatase activity	IBA	molecular function
GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	biological process
GO:0044255	cellular lipid metabolic process	IBA	biological process
GO:0019432	triglyceride biosynthetic process	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0003713	transcription coactivator activity	IBA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006631	fatty acid metabolic process	IEA	biological process
GO:0006629	lipid metabolic process	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0008195	phosphatidate phosphatase activity	IEA	molecular function
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0006646	phosphatidylethanolamine biosynthetic process	TAS	biological process
GO:0006656	phosphatidylcholine biosynthetic process	TAS	biological process
GO:0008195	phosphatidate phosphatase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0016311	dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04150	mTOR signaling pathway
hsa00564	Glycerophospholipid metabolism
hsa00561	Glycerolipid metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq