• Gene id: 64805

Gene Summary

• Gene Symbol: P2RY12   Gene   UCSC   Ensembl
• Aliases: ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999
• Gene name: purinergic receptor P2Y12
• Alternate names: P2Y purinoceptor 12, ADP-glucose receptor, G-protein coupled receptor SP1999, Gi-coupled ADP receptor HORK3, P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled, 12, putative G-protein coupled receptor,
• Gene location: 3q25.1 (151384752: 151336842)     Exons: 3     NC_000003.12
• Gene summary(Entrez): The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor
• OMIM: 600515

Protein Summary

• Protein general information: Q9H244  
  • Name: P2Y purinoceptor 12 (P2Y12) (ADP glucose receptor) (ADPG R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999)
  • Length: 342  
  • Mass: 39439
  • Tissue specificity: Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain. {ECO
• Sequence:

  MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMIL
  TFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWA
  FMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRG
  VGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFF
  LCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM

• Structural information:
  • Interpro: IPR000276  IPR017452  IPR005394  
  • Prosite: PS50262
  • PDB: 1T78 1VZ1 1Y9C 4NTJ 4PXZ 4PY0
  • PDBsum: 1T78 1VZ1 1Y9C 4NTJ 4PXZ 4PY0
  • DIP: 61226
  • STRING: ENSP00000307259
• Other Databases: GeneCards:  P2RY12  Malacards:  P2RY12

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISS	biological process
GO:0007202	activation of phospholipase C activity	TAS	biological process
GO:1904141	positive regulation of microglial cell migration	ISS	biological process
GO:1904141	positive regulation of microglial cell migration	ISS	biological process
GO:1904141	positive regulation of microglial cell migration	TAS	biological process
GO:0035585	calcium-mediated signaling using extracellular calcium source	ISS	biological process
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	TAS	biological process
GO:0005623	obsolete cell	TAS	cellular component
GO:1900029	positive regulation of ruffle assembly	ISS	biological process
GO:1900029	positive regulation of ruffle assembly	TAS	biological process
GO:1904124	microglial cell migration	TAS	biological process
GO:0048678	response to axon injury	ISS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0050921	positive regulation of chemotaxis	ISS	biological process
GO:0071318	cellular response to ATP	ISS	biological process
GO:0030032	lamellipodium assembly	ISS	biological process
GO:0021808	cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration	ISS	biological process
GO:0021808	cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration	ISS	biological process
GO:0033630	positive regulation of cell adhesion mediated by integrin	ISS	biological process
GO:0030030	cell projection organization	ISS	biological process
GO:0019722	calcium-mediated signaling	ISS	biological process
GO:0033626	positive regulation of integrin activation by cell surface receptor linked signal transduction	ISS	biological process
GO:0050920	regulation of chemotaxis	TAS	biological process
GO:0050920	regulation of chemotaxis	ISS	biological process
GO:0051897	positive regulation of protein kinase B signaling	ISS	biological process
GO:0051897	positive regulation of protein kinase B signaling	ISS	biological process
GO:0006930	substrate-dependent cell migration, cell extension	ISS	biological process
GO:0071318	cellular response to ATP	ISS	biological process
GO:0005886	plasma membrane	ISS	cellular component
GO:1904139	regulation of microglial cell migration	ISS	biological process
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	IBA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IBA	biological process
GO:0031224	intrinsic component of membrane	IDA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IDA	biological process
GO:0001621	G protein-coupled ADP receptor activity	IDA	molecular function
GO:0070527	platelet aggregation	IMP	biological process
GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP	biological process
GO:0001621	G protein-coupled ADP receptor activity	IMP	molecular function
GO:0007596	blood coagulation	IEA	biological process
GO:0045028	G protein-coupled purinergic nucleotide receptor activity	IEA	molecular function
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007596	blood coagulation	IEA	biological process
GO:0007599	hemostasis	IEA	biological process
GO:0007165	signal transduction	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005085	guanyl-nucleotide exchange factor activity	TAS	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0071318	cellular response to ATP	IEA	biological process
GO:0044298	cell body membrane	IEA	cellular component
GO:0043270	positive regulation of ion transport	IEA	biological process
GO:0031253	cell projection membrane	IEA	cellular component
GO:0030168	platelet activation	IEA	biological process
GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA	biological process
GO:0001609	G protein-coupled adenosine receptor activity	IEA	molecular function
GO:1904141	positive regulation of microglial cell migration	IEA	biological process
GO:0071318	cellular response to ATP	IEA	biological process
GO:0051924	regulation of calcium ion transport	IEA	biological process
GO:0050921	positive regulation of chemotaxis	IEA	biological process
GO:0048678	response to axon injury	IEA	biological process
GO:0045596	negative regulation of cell differentiation	IEA	biological process
GO:0043491	protein kinase B signaling	IEA	biological process
GO:0035585	calcium-mediated signaling using extracellular calcium source	IEA	biological process
GO:0033630	positive regulation of cell adhesion mediated by integrin	IEA	biological process
GO:0033626	positive regulation of integrin activation by cell surface receptor linked signal transduction	IEA	biological process
GO:0030032	lamellipodium assembly	IEA	biological process
GO:0030030	cell projection organization	IEA	biological process
GO:0021808	cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration	IEA	biological process
GO:0010700	negative regulation of norepinephrine secretion	IEA	biological process
GO:0008347	glial cell migration	IEA	biological process
GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IEA	biological process
GO:0005901	caveola	IEA	cellular component
GO:1904139	regulation of microglial cell migration	IEA	biological process
GO:0150063	visual system development	IEA	biological process
GO:0071407	cellular response to organic cyclic compound	IEA	biological process
GO:0006930	substrate-dependent cell migration, cell extension	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0001621	G protein-coupled ADP receptor activity	IEA	molecular function
GO:1900029	positive regulation of ruffle assembly	IEA	biological process
GO:0071805	potassium ion transmembrane transport	IEA	biological process
GO:0070588	calcium ion transmembrane transport	IEA	biological process
GO:0070527	platelet aggregation	IEA	biological process
GO:0051897	positive regulation of protein kinase B signaling	IEA	biological process
GO:0050920	regulation of chemotaxis	IEA	biological process
GO:0019722	calcium-mediated signaling	IEA	biological process
GO:0009925	basal plasma membrane	IEA	cellular component
GO:0009897	external side of plasma membrane	IEA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0001973	G protein-coupled adenosine receptor signaling pathway	IEA	biological process
GO:0001621	G protein-coupled ADP receptor activity	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0035589	G protein-coupled purinergic nucleotide receptor signaling pathway	IEA	biological process
GO:0035589	G protein-coupled purinergic nucleotide receptor signaling pathway	IEA	biological process
GO:0035589	G protein-coupled purinergic nucleotide receptor signaling pathway	IEA	biological process
GO:0035589	G protein-coupled purinergic nucleotide receptor signaling pathway	IEA	biological process
GO:0035589	G protein-coupled purinergic nucleotide receptor signaling pathway	IEA	biological process
GO:0035589	G protein-coupled purinergic nucleotide receptor signaling pathway	IEA	biological process
GO:0009986	cell surface	HDA	cellular component
GO:0007599	hemostasis	NAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa04611	Platelet activation

Diseases

Associated diseases	References
Bleeding disorder platelet-type	KEGG:H01235
Bleeding disorder platelet-type	KEGG:H01235
Peripheral artery disease	PMID:14662702
Asthma	PMID:22010907
cerebrovascular disease	PMID:15933261
Systemic lupus erythematosus	PMID:15304052
type 2 diabetes mellitus	PMID:15483100
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)