• Gene id: 64780

Gene Summary

• Gene Symbol: MICAL1   Gene   UCSC   Ensembl
• Aliases: MICAL, MICAL-1, NICAL
• Gene name: microtubule associated monooxygenase, calponin and LIM domain containing 1
• Alternate names: [F-actin]-monooxygenase MICAL1, NEDD9-interacting protein with calponin homology and LIM domains, [F-actin]-methionine sulfoxide oxidase MICAL1, molecule interacting with CasL protein 1, protein-methionine sulfoxide oxidase MICAL1,
• Gene location: 6q21 (109465967: 109444061)     Exons: 26     NC_000006.12
• Gene summary(Entrez): This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regul
• OMIM: 609743

Protein Summary

• Protein general information: Q8TDZ2  
  • Name: [F actin] monooxygenase MICAL1 (EC 1.14.13.225) (Molecule interacting with CasL protein 1) (MICAL 1) (NEDD9 interacting protein with calponin homology and LIM domains)
  • Length: 1067  
  • Mass: 117875
  • Tissue specificity: Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells. {ECO
• Sequence:

  MASPTSTNPAHAHFESFLQAQLCQDVLSSFQELCGALGLEPGGGLPQYHKIKDQLNYWSAKSLWTKLDKRAGQPV
  YQQGRACTSTKCLVVGAGPCGLRVAVELALLGARVVLVEKRTKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTG
  TLDHISIRQLQLLLLKVALLLGVEIHWGVTFTGLQPPPRKGSGWRAQLQPNPPAQLANYEFDVLISAAGGKFVPE
  GFKVREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQSFFQSLLKATGIDLENIVYYKDDTHYFVMTAKK
  QCLLRLGVLRQDWPDTNRLLGSANVVPEALQRFTRAAADFATHGKLGKLEFAQDAHGQPDVSAFDFTSMMRAESS
  ARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAESLEVLAERESLYQLLSQTSPEN
  MHRNVAQYGLDPATRYPNLNLRAVTPNQVRDLYDVLAKEPVQRNNDKTDTGMPATGSAGTQEELLRWCQEQTAGY
  PGVHVSDLSSSWADGLALCALVYRLQPGLLEPSELQGLGALEATAWALKVAENELGITPVVSAQAVVAGSDPLGL
  IAYLSHFHSAFKSMAHSPGPVSQASPGTSSAVLFLSKLQRTLQRSRAKENAEDAGGKKLRLEMEAETPSTEVPPD
  PEPGVPLTPPSQHQEAGAGDLCALCGEHLYVLERLCVNGHFFHRSCFRCHTCEATLWPGGYEQHPGDGHFYCLQH
  LPQTDHKAEGSDRGPESPELPTPSENSMPPGLSTPTASQEGAGPVPDPSQPTRRQIRLSSPERQRLSSLNLTPDP
  EMEPPPKPPRSCSALARHALESSFVGWGLPVQSPQALVAMEKEEKESPFSSEEEEEDVPLDSDVEQALQTFAKTS
  GTMNNYPTWRRTLLRRAKEEEMKRFCKAQTIQRRLNEIEAALRELEAEGVKLELALRRQSSSPEQQKKLWVGQLL
  QLVDKKNSLVAEEAELMITVQELNLEEKQWQLDQELRGYMNREENLKTAADRQAEDQVLRKLVDLVNQRDALIRF
  QEERRLSELALGTGAQG

• Structural information:
  • Protein Domains: (508..61-)
    (/note="Calponin-homology-(CH))
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00044-)
    (695..75-)
    (/note="LIM-zinc-binding)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00125-)
    (918..106-)
    (/note="bMERB-)
    (/evidence="ECO:0000255|P-)
  • Interpro: IPR022735  IPR001715  IPR036872  IPR002938  IPR036188   IPR029937  IPR001781  
  • Prosite: PS51848 PS50021 PS00478 PS50023
  • CDD: cd00014
  • PDB: 1WYL 2CO8 2DK9 5LE0 5LPN
  • PDBsum: 1WYL 2CO8 2DK9 5LE0 5LPN
  • STRING: ENSP00000351664
• Other Databases: GeneCards:  MICAL1  Malacards:  MICAL1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051015	actin filament binding	IBA	molecular function
GO:0015629	actin cytoskeleton	IBA	cellular component
GO:0051017	actin filament bundle assembly	IBA	biological process
GO:0005886	plasma membrane	IBA	cellular component
GO:0071949	FAD binding	IDA	molecular function
GO:0055114	oxidation-reduction process	IDA	biological process
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IDA	molecular function
GO:0003779	actin binding	IDA	molecular function
GO:0055114	oxidation-reduction process	IDA	biological process
GO:0016174	NAD(P)H oxidase (H(2)O(2)-forming activity	IDA	molecular function
GO:0016174	NAD(P)H oxidase (H(2)O(2)-forming activity	IDA	molecular function
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IDA	molecular function
GO:0030042	actin filament depolymerization	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0030496	midbody	IDA	cellular component
GO:0045171	intercellular bridge	IDA	cellular component
GO:0030042	actin filament depolymerization	IDA	biological process
GO:0019417	sulfur oxidation	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0003779	actin binding	IEA	molecular function
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IEA	molecular function
GO:0019417	sulfur oxidation	IEA	biological process
GO:0071949	FAD binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0030042	actin filament depolymerization	IEA	biological process
GO:0004497	monooxygenase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0003779	actin binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0007596	blood coagulation	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0001933	negative regulation of protein phosphorylation	IEA	biological process
GO:0003779	actin binding	IEA	molecular function
GO:0004497	monooxygenase activity	IEA	molecular function
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IEA	molecular function
GO:0017137	Rab GTPase binding	IEA	molecular function
GO:0019417	sulfur oxidation	IEA	biological process
GO:0043066	negative regulation of apoptotic process	IEA	biological process
GO:0071949	FAD binding	IEA	molecular function
GO:1903305	regulation of regulated secretory pathway	IEA	biological process
GO:1990026	hippocampal mossy fiber expansion	IEA	cellular component
GO:0019901	protein kinase binding	IEA	molecular function
GO:0030042	actin filament depolymerization	IEA	biological process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA	biological process
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0030496	midbody	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005882	intermediate filament	NAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0007010	cytoskeleton organization	NAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0017124	SH3 domain binding	IPI	molecular function
GO:0007165	signal transduction	NAS	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq